Diltiazem
- Generic Name
- Diltiazem
- Brand Names
- Cardizem, Cartia, Matzim, Taztia, Tiadylt, Tiazac
- Drug Type
- Small Molecule
- Chemical Formula
- C22H26N2O4S
- CAS Number
- 42399-41-7
- Unique Ingredient Identifier
- EE92BBP03H
- Background
Diltiazem is a benzothiazepine derivative with antihypertensive and vasodilating properties. Approved in 1982 by the FDA, it is a member of the non-dihydropyridine calcium channel blockers drug class. It works through various mechanisms of action, but it primarily works by inhibiting the calcium influx into cardiac and vascular smooth muscle during depolariz...
- Indication
Oral
Indicated for the management of hypertension, to lower blood pressure, alone or in combination with other antihypertensive agents.
Indicated for use to improve exercise tolerance in patients with chronic stable angina.
Indicated for the management of variant angina (Prinzmetal's angina).
Intravenous
...
- Associated Conditions
- Angina Pectoris, Variant, Anginal Pain, Atrial Fibrillation, Atrial Flutter, Chronic Stable Angina Pectoris, Dilated Cardiomyopathies, Idiopathic, Fissure;Anal, Hypertension, Paroxysmal Supraventricular Tachycardia (PSVT), Proteinuria, Pulmonary Hypertension (PH), Leg cramps, Prophylaxis of migraine headaches
- Associated Therapies
- -
Ability of Late Sodium or Calcium Current Block to Balance the ECG Effects of Potassium Current Block
- Conditions
- Interventions
- First Posted Date
- 2014-12-04
- Last Posted Date
- 2016-06-08
- Lead Sponsor
- Food and Drug Administration (FDA)
- Target Recruit Count
- 22
- Registration Number
- NCT02308748
A Study of LY2623091 in Healthy Participants
- Conditions
- Interventions
- First Posted Date
- 2014-11-24
- Last Posted Date
- 2020-06-26
- Lead Sponsor
- Eli Lilly and Company
- Target Recruit Count
- 48
- Registration Number
- NCT02300259
- Locations
- 🇺🇸
Covance Clinical Research Inc, Daytona Beach, Florida, United States
Treatment Of Chronic Anal Fissure
- Conditions
- Interventions
- First Posted Date
- 2014-06-06
- Last Posted Date
- 2020-01-14
- Lead Sponsor
- Bispebjerg Hospital
- Target Recruit Count
- 55
- Registration Number
- NCT02158013
- Locations
- 🇩🇰
Department of Surgery P, Aarhus University Hospital, Aarhus, Denmark
🇩🇰Digestive Disease Center, Bispebjerg Hospital, Copenhagen, Denmark
Randomized Trial Comparing Diltiazem and Metoprolol For Atrial Fibrillation Rate Control
- First Posted Date
- 2014-01-01
- Last Posted Date
- 2017-08-09
- Lead Sponsor
- CAMC Health System
- Target Recruit Count
- 150
- Registration Number
- NCT02025465
- Locations
- 🇺🇸
Charleston Area Medical Center, Charleston, West Virginia, United States
Comparison of Diltiazem and Metoprolol in the Management of Acute Atrial Fibrillation or Atrial Flutter
- Conditions
- Interventions
- First Posted Date
- 2013-08-02
- Last Posted Date
- 2014-05-15
- Lead Sponsor
- Antonios Likourezos
- Target Recruit Count
- 54
- Registration Number
- NCT01914926
- Locations
- 🇺🇸
Maimonides Medical Center, Brooklyn, New York, United States
Study to Determine the Effect of Repeated Administration of Diltiazem on the Pharmacokinetics of Darapladib (Sb-480848).
- First Posted Date
- 2013-05-13
- Last Posted Date
- 2017-07-13
- Lead Sponsor
- GlaxoSmithKline
- Target Recruit Count
- 36
- Registration Number
- NCT01852565
- Locations
- 🇺🇸
GSK Investigational Site, Baltimore, Maryland, United States
Ischaemia-réperfusion During the Coronary Surgery With Beating Heart
- Conditions
- Interventions
- First Posted Date
- 2013-01-18
- Last Posted Date
- 2013-01-18
- Lead Sponsor
- University Hospital, Strasbourg, France
- Target Recruit Count
- 120
- Registration Number
- NCT01771978
- Locations
- 🇫🇷
Department of Anaesthesiology, Strasbourg, France
Rate Control in Atrial Fibrillation
- Conditions
- Interventions
- First Posted Date
- 2012-08-01
- Last Posted Date
- 2012-08-01
- Lead Sponsor
- Tehran University of Medical Sciences
- Target Recruit Count
- 90
- Registration Number
- NCT01655303
- Locations
- 🇮🇷
Rasoul-e-Akram Hospital, Tehran, Iran, Islamic Republic of
A Drug Interaction Study of Boceprevir in Combination With Amlodipine or Diltiazem in Healthy Volunteers
- First Posted Date
- 2012-03-09
- Last Posted Date
- 2015-01-09
- Lead Sponsor
- Ottawa Hospital Research Institute
- Registration Number
- NCT01549496
- Locations
- 🇨🇦
Clinical Investigation Unit, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
Control of Emergence Blood Pressure During Craniotomy for Tumor Surgery Between Labetolol and Diltiazem
- First Posted Date
- 2011-08-03
- Last Posted Date
- 2014-04-01
- Lead Sponsor
- Mahidol University
- Target Recruit Count
- 184
- Registration Number
- NCT01408524
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.