Diltiazem
- Generic Name
- Diltiazem
- Brand Names
- Cardizem, Cartia, Matzim, Taztia, Tiadylt, Tiazac
- Drug Type
- Small Molecule
- Chemical Formula
- C22H26N2O4S
- CAS Number
- 42399-41-7
- Unique Ingredient Identifier
- EE92BBP03H
- Background
Diltiazem is a benzothiazepine derivative with antihypertensive and vasodilating properties. Approved in 1982 by the FDA, it is a member of the non-dihydropyridine calcium channel blockers drug class. It works through various mechanisms of action, but it primarily works by inhibiting the calcium influx into cardiac and vascular smooth muscle during depolariz...
- Indication
Oral
Indicated for the management of hypertension, to lower blood pressure, alone or in combination with other antihypertensive agents.
Indicated for use to improve exercise tolerance in patients with chronic stable angina.
Indicated for the management of variant angina (Prinzmetal's angina).
Intravenous
...
- Associated Conditions
- Angina Pectoris, Variant, Anginal Pain, Atrial Fibrillation, Atrial Flutter, Chronic Stable Angina Pectoris, Dilated Cardiomyopathies, Idiopathic, Fissure;Anal, Hypertension, Paroxysmal Supraventricular Tachycardia (PSVT), Proteinuria, Pulmonary Hypertension (PH), Leg cramps, Prophylaxis of migraine headaches
- Associated Therapies
- -
A Study to Evaluate the Safety, Tolerability, Drug Levels and Drug Effects of Single and Multiple Doses of BMS-986209 in Healthy Participants
- Conditions
- Interventions
- First Posted Date
- 2019-11-07
- Last Posted Date
- 2022-01-04
- Lead Sponsor
- Bristol-Myers Squibb
- Target Recruit Count
- 114
- Registration Number
- NCT04154800
- Locations
- 🇺🇸
PPD Development, LP, Austin, Texas, United States
Comparative Evaluation of MEBO Ointment and Topical Diltiazem Ointment in the Treatment of Acute Anal Fissure
- First Posted Date
- 2019-11-06
- Last Posted Date
- 2024-07-31
- Lead Sponsor
- American University of Beirut Medical Center
- Target Recruit Count
- 183
- Registration Number
- NCT04153032
- Locations
- 🇱🇧
American University of Beirut, Beirut, Lebanon
Efficacy of Medical Therapy in Women and Men With Angina and Myocardial Bridging
- Conditions
- Interventions
- First Posted Date
- 2019-10-17
- Last Posted Date
- 2023-11-29
- Lead Sponsor
- Stanford University
- Target Recruit Count
- 360
- Registration Number
- NCT04130438
- Locations
- 🇺🇸
Stanford University, Stanford, California, United States
The Effect of Nebivolol in Hypertensive Patients With Coronary Arterial Spasm
- Conditions
- Interventions
- First Posted Date
- 2019-04-29
- Last Posted Date
- 2020-03-10
- Lead Sponsor
- Korea University Anam Hospital
- Target Recruit Count
- 51
- Registration Number
- NCT03930433
- Locations
- 🇰🇷
Korea University Anam Hospital, Seoul, Korea, Republic of
Celiprolol Versus Ditiazem for the Prevention of Postoperative Cardiac Arrythmias in Thoracic Surgery
- First Posted Date
- 2018-11-26
- Last Posted Date
- 2018-11-26
- Lead Sponsor
- Abderrahmane Mami Hospital
- Target Recruit Count
- 30
- Registration Number
- NCT03752931
- Locations
- 🇹🇳
Hospital Abderrahmane Mami, Ariana, Tunisia
Efficiency of Antagonist Drugs of the Cellular Transcriptomic Signature of Influenza A Virus Infection.
- First Posted Date
- 2017-07-11
- Last Posted Date
- 2023-02-06
- Lead Sponsor
- University Hospital, Lille
- Target Recruit Count
- 85
- Registration Number
- NCT03212716
- Locations
- 🇫🇷
Chu Amiens Picardie, Amiens, France
🇫🇷CH ARRAS, Arras, France
🇫🇷Ch Pierre Oudot Bourgoin Jallieu, Bourgoin-Jallieu, France
Rate Control in Atrial Fibrillation II
- Conditions
- Interventions
- First Posted Date
- 2016-03-02
- Last Posted Date
- 2022-01-05
- Lead Sponsor
- Asker & Baerum Hospital
- Target Recruit Count
- 122
- Registration Number
- NCT02695992
- Locations
- 🇳🇴
Vestre Viken Hospital Trust, Baerum Hospital, Rud, Akershus, Norway
A Phase I Study to Assess PK of AZD7986 Alone & With Verapamil, Itraconazole or Diltiazem in Healthy Subjects
- Conditions
- Interventions
- First Posted Date
- 2016-01-12
- Last Posted Date
- 2018-02-23
- Lead Sponsor
- AstraZeneca
- Target Recruit Count
- 15
- Registration Number
- NCT02653872
- Locations
- 🇬🇧
Research Site, London, United Kingdom
Pharmacokinetic Interaction Between Diltiazem and ACT-541468 in Healthy Subjects
- First Posted Date
- 2015-08-18
- Last Posted Date
- 2018-07-10
- Lead Sponsor
- Idorsia Pharmaceuticals Ltd.
- Target Recruit Count
- 14
- Registration Number
- NCT02526888
- Locations
- 🇩🇪
CRS Clinical Research Services Kiel GmbH, Kiel, Germany
A Study to Estimate the Effect of CYP3A4 Inhibitors (Itraconazole, Diltiazem or Verapamil) on the Pharmacokinetics of Single Dose PF- 00489791 in Healthy Volunteers
- Conditions
- Interventions
- First Posted Date
- 2014-12-18
- Last Posted Date
- 2016-09-16
- Lead Sponsor
- Pfizer
- Target Recruit Count
- 22
- Registration Number
- NCT02319148
- Locations
- 🇧🇪
Pfizer Clinical Research Unit, Brussels, Belgium
Drug Development Updates
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