Zidovudine
- Generic Name
- Zidovudine
- Brand Names
- Combivir, Retrovir, Trizivir
- Drug Type
- Small Molecule
- Chemical Formula
- C10H13N5O4
- CAS Number
- 30516-87-1
- Unique Ingredient Identifier
- 4B9XT59T7S
- Background
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia. [PubChem]
- Indication
Used in combination with other antiretroviral agents for the treatment of human immunovirus (HIV) infections.
- Associated Conditions
- HIV Transmission, Human Immunodeficiency Virus (HIV) Infections, Perinatal HIV transmission
- Associated Therapies
- -
A Comparison of Zidovudine Plus Lamivudine Versus ddI Used Alone or in Combination With Zidovudine in HIV-1 Infected Children
- Conditions
- HIV Infections
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2011-03-02
- Target Recruit Count
- 740
- Registration Number
- NCT00001066
- Locations
- 🇺🇸
HRS Palm Beach County Public Health Unit, West Palm Beach, Florida, United States
🇺🇸Children's Hosp of Washington DC, Washington, District of Columbia, United States
🇺🇸Howard Univ Hosp, Washington, District of Columbia, United States
A Study of Nevirapine Used Alone or in Combination With AZT in HIV-1-Infected Children
- Conditions
- HIV Infections
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2011-03-01
- Target Recruit Count
- 35
- Registration Number
- NCT00001111
- Locations
- 🇺🇸
UCLA Med Ctr / Pediatrics, Los Angeles, California, United States
🇺🇸Univ of Miami (Pediatric), Miami, Florida, United States
🇺🇸Univ of Massachusetts Med Ctr / Biotech II, Worcester, Massachusetts, United States
A Study of Three Drugs Plus Zidovudine in the Prevention of Infections in HIV-Infected Patients
- Conditions
- HIV InfectionsPneumonia, Pneumocystis Carinii
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-04
- Target Recruit Count
- 600
- Registration Number
- NCT00000991
- Locations
- 🇺🇸
Chicago Children's CRS, Chicago, Illinois, United States
🇺🇸Johns Hopkins Adult AIDS CRS, Baltimore, Maryland, United States
🇺🇸Case CRS, Cleveland, Ohio, United States
A Study of AZT in HIV-Infected Patients With AIDS-Related Kaposi's Sarcoma
- Conditions
- HIV Infections
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-04
- Target Recruit Count
- 240
- Registration Number
- NCT00000994
- Locations
- 🇺🇸
Los Angeles County - USC Med Ctr, Los Angeles, California, United States
🇺🇸UCLA CARE Ctr, Los Angeles, California, United States
🇺🇸Univ of California / San Diego Treatment Ctr, San Diego, California, United States
A Study of Pentamidine in the Prevention of Pneumocystis Carinii Pneumonia
- Conditions
- HIV InfectionsPneumonia, Pneumocystis Carinii
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-04
- Target Recruit Count
- 20
- Registration Number
- NCT00001003
- Locations
- 🇺🇸
SUNY - Stony Brook, Stony Brook, New York, United States
The Safety of Different Dose Levels of Zidovudine in HIV-Infected Children
- Conditions
- HIV Infections
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-04
- Target Recruit Count
- 400
- Registration Number
- NCT00000983
- Locations
- 🇺🇸
UCLA Med Ctr / Pediatric, Los Angeles, California, United States
🇺🇸Children's Hosp of Los Angeles/UCLA Med Ctr, Los Angeles, California, United States
🇺🇸Cedars Sinai / UCLA Med Ctr, Los Angeles, California, United States
A Multicenter Placebo-Controlled Double-Blind Trial to Evaluate Azidothymidine (AZT) Treatment of the AIDS Dementia Complex and Central Nervous System (CNS) Human Immunodeficiency Virus (HIV) Infection
- Conditions
- HIV InfectionsAIDS Dementia Complex
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-03
- Target Recruit Count
- 315
- Registration Number
- NCT00000702
- Locations
- 🇺🇸
Louisiana State Univ Med Ctr / Tulane Med School, New Orleans, Louisiana, United States
🇺🇸Charity Hosp / Tulane Univ Med School, New Orleans, Louisiana, United States
🇺🇸Julio Arroyo, West Columbia, South Carolina, United States
Evaluation of Patients Who Have Not Had Success With Zidovudine
- Conditions
- HIV Infections
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-01
- Target Recruit Count
- 120
- Registration Number
- NCT00001025
- Locations
- 🇺🇸
SUNY / Health Sciences Ctr at Brooklyn, Brooklyn, New York, United States
🇺🇸Baystate Med Ctr of Springfield, Springfield, Massachusetts, United States
🇺🇸Univ of Alabama at Birmingham, Birmingham, Alabama, United States
Safety and Effectiveness of Azidothymidine (AZT) in HIV-Positive Patients With Hemophilia
- Conditions
- Hemophilia AHIV Infections
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-10-29
- Target Recruit Count
- 24
- Registration Number
- NCT00000705
- Locations
- 🇺🇸
SUNY / Erie County Med Ctr at Buffalo, Buffalo, New York, United States
🇺🇸Univ of Rochester Medical Center, Rochester, New York, United States
The Safety and Effects of 1592U89 Used Alone or in Combination With Other Anti-HIV Drugs in HIV-Infected Infants and Children
- Conditions
- HIV Infections
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-10-28
- Target Recruit Count
- 32
- Registration Number
- NCT00000865
- Locations
- 🇺🇸
UCSD Maternal, Child, and Adolescent HIV CRS, San Diego, California, United States
🇺🇸Usc La Nichd Crs, Los Angeles, California, United States
🇺🇸Tulane/LSU Maternal/Child CRS, New Orleans, Louisiana, United States
Drug Development Updates
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