Rabeprazole
- Generic Name
- Rabeprazole
- Brand Names
- Aciphex, Pariet
- Drug Type
- Small Molecule
- Chemical Formula
- C18H21N3O3S
- CAS Number
- 117976-89-3
- Unique Ingredient Identifier
- 32828355LL
- Background
Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion.
- Indication
For the treatment of acid-reflux disorders (GERD), peptic ulcer disease, H. pylori eradication, and prevention of gastroinetestinal bleeds with NSAID use.
- Associated Conditions
- Duodenal Ulcer, Gastric Ulcer, Gastro-esophageal Reflux Disease (GERD), Heartburn, Helicobacter Pylori Infection, Non-erosive Reflux Esophagitis Disease (NERD), Vomiting, Zollinger-Ellison Syndrome, Develop NSAID-induced gastric ulcers, Erosive reflux esophagitis
- Associated Therapies
- -
Sleep Disorders and Gastroesophageal Reflux Disease (GERD)
- First Posted Date
- 2006-02-06
- Last Posted Date
- 2007-04-27
- Lead Sponsor
- University of North Carolina
- Target Recruit Count
- 20
- Registration Number
- NCT00287391
- Locations
- 🇺🇸
UNC Gastroenterology and UNC Sleep Disorders Center, Chapel Hill, North Carolina, United States
A Study of Efficacy and Safety of "On-demand" Maintenance Therapy With Rabeprazole in Patients With Non-erosive Reflux Disease (NERD)
- Conditions
- First Posted Date
- 2005-10-12
- Last Posted Date
- 2010-11-30
- Lead Sponsor
- Janssen Pharmaceutica N.V., Belgium
- Target Recruit Count
- 422
- Registration Number
- NCT00236392
E3810-A001-313: Efficacy and Safety of 10 mg Rabeprazole for Treating Heartburn in Frequent Sufferers
- First Posted Date
- 2005-10-12
- Last Posted Date
- 2010-04-06
- Lead Sponsor
- Eisai Inc.
- Target Recruit Count
- 629
- Registration Number
- NCT00236184
- Locations
- 🇺🇸
Jeffrey L. Newman, Vista, California, United States
E3810-A001-312: Efficacy and Safety of 10 mg Rabeprazole for Treating Heartburn in Frequent Sufferers
- First Posted Date
- 2005-10-12
- Last Posted Date
- 2009-11-11
- Lead Sponsor
- Eisai Inc.
- Target Recruit Count
- 619
- Registration Number
- NCT00236197
- Locations
- 🇺🇸
New York Center For Clinical Research, Lake Success, New York, United States
Improvement in Bronchial Asthma in Patients With Extraesophageal Reflux After Acid Suppression
- Conditions
- First Posted Date
- 2005-10-06
- Last Posted Date
- 2011-07-22
- Lead Sponsor
- Ponce Gastroenterology Research
- Target Recruit Count
- 40
- Registration Number
- NCT00234117
- Locations
- 🇵🇷
Ponce Gastroentrology Research, Ponce, Puerto Rico
Rabeprazole in Subjects With Gastroesophageal Reflux Disease (GERD)
- Conditions
- First Posted Date
- 2005-09-22
- Last Posted Date
- 2009-05-08
- Lead Sponsor
- University of Kansas
- Target Recruit Count
- 24
- Registration Number
- NCT00222170
- Locations
- 🇺🇸
University of Kansas Medical Center, Kansas City, Kansas, United States
Evaluate the Effects on Asthma Control of Rabeprazole Given Twice Daily in Subjects With Asthma.
- Conditions
- First Posted Date
- 2005-09-22
- Last Posted Date
- 2011-06-23
- Lead Sponsor
- Associated Scientists to Help Minimize Allergies
- Target Recruit Count
- 80
- Registration Number
- NCT00214552
- Locations
- 🇺🇸
ASTHMA, Inc., Seattle, Washington, United States
A Study of the Safety of Rabeprazole Administered to Adults With Gastroesophageal Reflux Disease (GERD)
- Conditions
- First Posted Date
- 2005-09-22
- Last Posted Date
- 2010-04-26
- Lead Sponsor
- Janssen Cilag Pharmaceutica S.A.C.I., Greece
- Target Recruit Count
- 191
- Registration Number
- NCT00216489
Study of the Safety and Effectiveness of Rabeprazole in Treatment of Helicobacter Pylori Infection in Adults.
- Conditions
- First Posted Date
- 2005-09-22
- Last Posted Date
- 2010-04-26
- Lead Sponsor
- Janssen Cilag Pharmaceutica S.A.C.I., Greece
- Target Recruit Count
- 80
- Registration Number
- NCT00216450
Rabeprazole Protection of Aspirin Induced Gastric Damage.
- Conditions
- First Posted Date
- 2005-09-22
- Last Posted Date
- 2008-01-11
- Lead Sponsor
- Temple University
- Target Recruit Count
- 30
- Registration Number
- NCT00220857
- Locations
- 🇺🇸
Temple University School of Medicine, Philadelphia, Pennsylvania, United States
Drug Development Updates
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