Rabeprazole
- Generic Name
- Rabeprazole
- Brand Names
- Aciphex, Pariet
- Drug Type
- Small Molecule
- Chemical Formula
- C18H21N3O3S
- CAS Number
- 117976-89-3
- Unique Ingredient Identifier
- 32828355LL
- Background
Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion.
- Indication
For the treatment of acid-reflux disorders (GERD), peptic ulcer disease, H. pylori eradication, and prevention of gastroinetestinal bleeds with NSAID use.
- Associated Conditions
- Duodenal Ulcer, Gastric Ulcer, Gastro-esophageal Reflux Disease (GERD), Heartburn, Helicobacter Pylori Infection, Non-erosive Reflux Esophagitis Disease (NERD), Vomiting, Zollinger-Ellison Syndrome, Develop NSAID-induced gastric ulcers, Erosive reflux esophagitis
Double-dose Rabeprazole Accelerates and Sustains the Control of Symptoms in Patients With NERD
- Conditions
- Gastroesophageal Reflux Disease
- Interventions
- First Posted Date
- 2011-07-12
- Last Posted Date
- 2012-01-18
- Lead Sponsor
- Inje University
- Registration Number
- NCT01391715
- Locations
- 🇰🇷
Haeundae Paik Hospital, Inje University School of Medicine, Busan, Korea, Republic of
Quality of Life in New Treatable Therapy as Rabeprazole Option for Refractory Reflux Esophagitis
- First Posted Date
- 2011-03-23
- Last Posted Date
- 2023-07-24
- Lead Sponsor
- Eisai Co., Ltd.
- Target Recruit Count
- 2157
- Registration Number
- NCT01321567
A 3-Part Study to Determine the Relative Bioavailability of Capsule and Tablet Formulations of GDC-0980, the Effect of Food, and the Effect of Rabeprazole on the Pharmacokinetics of the Tablet
- First Posted Date
- 2011-02-01
- Last Posted Date
- 2022-12-13
- Lead Sponsor
- Genentech, Inc.
- Target Recruit Count
- 46
- Registration Number
- NCT01287091
- Locations
- 🇺🇸
Investigational Site, Austin, Texas, United States
A Study to Investigate Use Patterns and Safety in Simulated Actual Over-the-counter (OTC) Use of Rabeprazole Sodium for the Treatment of Heartburn Symptoms
- First Posted Date
- 2011-01-31
- Last Posted Date
- 2011-01-31
- Lead Sponsor
- Eisai Inc.
- Target Recruit Count
- 1500
- Registration Number
- NCT01286194
- Locations
- 🇺🇸
Eckerd Drug #234, Marietta, Georgia, United States
🇺🇸The Medicine Shoppe, Kansas Ciry, Kansas, United States
🇺🇸Studewood Pharmacy, Houston, Texas, United States
A Study to Evaluate the Effect of a Proton-Pump Inhibitor (Rabeprazole) on the Relative Bioavailability of Cobimetinib in Healthy Participants
- First Posted Date
- 2011-01-17
- Last Posted Date
- 2017-05-10
- Lead Sponsor
- Genentech, Inc.
- Target Recruit Count
- 20
- Registration Number
- NCT01277718
Prognostic Study of Gastric MALT Lymphoma After Eradication of Helicobacter Pylori
- Conditions
- Gastric Low-grade MALT Lymphoma With Helicobacter Pylori Positive
- Interventions
- First Posted Date
- 2010-12-22
- Last Posted Date
- 2017-02-27
- Lead Sponsor
- Eisai Co., Ltd.
- Target Recruit Count
- 108
- Registration Number
- NCT01264822
A Bioequivalence Study of 2 Formulations of Rabeprazole Sodium and Evaluation of the Effect of Food on Rabeprazole Sodium in Healthy Adult Volunteers
- Conditions
- Healthy
- First Posted Date
- 2010-11-16
- Last Posted Date
- 2012-10-30
- Target Recruit Count
- 78
- Registration Number
- NCT01241409
Study of the Ability of Betaine Hydrochloride to Increase Stomach Acid in Healthy Volunteers
- Conditions
- Pharmacodynamic
- Interventions
- Dietary Supplement: betaine hydrochloride
- First Posted Date
- 2010-11-09
- Last Posted Date
- 2013-07-02
- Lead Sponsor
- University of California, San Francisco
- Target Recruit Count
- 6
- Registration Number
- NCT01237353
- Locations
- 🇺🇸
University of California San Francisco, San Francisco, California, United States
A Clinical Pharmacological Study of Rabeprazole Sodium in Japanese Healthy Adult Male Volunteers (Study E3810)
- Conditions
- Healthy
- Interventions
- First Posted Date
- 2010-09-15
- Last Posted Date
- 2012-11-30
- Lead Sponsor
- Eisai Co., Ltd.
- Target Recruit Count
- 24
- Registration Number
- NCT01202071
A Relative Bioavailability Study of Rabeprazole Sodium Administered With Different Dosing Vehicles in Healthy Adult Volunteers
- Conditions
- Healthy
- First Posted Date
- 2010-08-23
- Last Posted Date
- 2013-01-23
- Target Recruit Count
- 35
- Registration Number
- NCT01186497
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.