Rabeprazole
- Generic Name
- Rabeprazole
- Brand Names
- Aciphex, Pariet
- Drug Type
- Small Molecule
- Chemical Formula
- C18H21N3O3S
- CAS Number
- 117976-89-3
- Unique Ingredient Identifier
- 32828355LL
- Background
Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion.
- Indication
For the treatment of acid-reflux disorders (GERD), peptic ulcer disease, H. pylori eradication, and prevention of gastroinetestinal bleeds with NSAID use.
- Associated Conditions
- Duodenal Ulcer, Gastric Ulcer, Gastro-esophageal Reflux Disease (GERD), Heartburn, Helicobacter Pylori Infection, Non-erosive Reflux Esophagitis Disease (NERD), Vomiting, Zollinger-Ellison Syndrome, Develop NSAID-induced gastric ulcers, Erosive reflux esophagitis
A Study to Evaluate the Effect on 24-hour, Intragastric pH of RAB ER 50-mg Capsules Compared With Esomeprazole (Nexium) 40 mg Capsules and Rabeprazole (Aciphex) 20-mg Tablets
- Conditions
- Healthy
- Interventions
- First Posted Date
- 2010-06-30
- Last Posted Date
- 2013-11-01
- Lead Sponsor
- Eisai Inc.
- Target Recruit Count
- 90
- Registration Number
- NCT01153659
- Locations
- 🇺🇸
Oklahoma Foundation for Digestive Research, Oklahoma City, Oklahoma, United States
A Study of Rabeprazole for Prevention of Non Steroidal Anti-inflammatory Drug -Associated Gastroduodenal Injury
- Conditions
- Arthritis, RheumatoidOsteoarthritisDyspepsia
- Interventions
- First Posted Date
- 2010-06-10
- Last Posted Date
- 2015-08-24
- Lead Sponsor
- Chinese University of Hong Kong
- Target Recruit Count
- 112
- Registration Number
- NCT01140828
- Locations
- 🇨🇳
Prince of Wales Hospital, Hong Kong, Hong Kong, China
The Effect of Proton Pump Inhibitors on Calcium and Bone Metabolism
- Conditions
- Calcium Metabolism Disorders
- Interventions
- First Posted Date
- 2010-06-08
- Last Posted Date
- 2013-01-28
- Lead Sponsor
- American University of Beirut Medical Center
- Target Recruit Count
- 58
- Registration Number
- NCT01139645
- Locations
- 🇱🇧
American University of Beirut - Medical Center, Beirut, Lebanon
Comparison of Antisecretory Effect of a Single Dose of Rabeprazole 20 mg and Omeprazole 20 mg in Obese Subjects
- Conditions
- Gastroesophageal Reflux
- Interventions
- First Posted Date
- 2010-06-03
- Last Posted Date
- 2010-09-24
- Lead Sponsor
- Nantes University Hospital
- Registration Number
- NCT01136317
- Locations
- 🇫🇷
CHU de Nantes, Nantes, France
A Pharmacokinetic and Relative Bioavailability Study With Rabeprazole Sodium in Healthy Adult Volunteers
- First Posted Date
- 2010-04-12
- Last Posted Date
- 2014-05-28
- Target Recruit Count
- 36
- Registration Number
- NCT01101646
A Study of E3810 for Japanese Subjects With Functional Dyspepsia (SAMURAI Study: Suppression of Acid Milieu With Rabeprazole Improving Functional Dyspepsia ) (Study E3810-J081-204)
- First Posted Date
- 2010-03-18
- Last Posted Date
- 2013-12-24
- Lead Sponsor
- Eisai Co., Ltd.
- Target Recruit Count
- 338
- Registration Number
- NCT01089543
A Pilot Cross-over Bioequivalence Study of E3810 for Healthy Japanese Male (Under Postprandial Condition)
- First Posted Date
- 2010-03-12
- Last Posted Date
- 2013-05-13
- Lead Sponsor
- Eisai Co., Ltd.
- Target Recruit Count
- 16
- Registration Number
- NCT01085708
Study of E3810 for Healthy Japanese Male (Under Fasting Condition)
- First Posted Date
- 2010-03-12
- Last Posted Date
- 2013-05-13
- Lead Sponsor
- Eisai Co., Ltd.
- Target Recruit Count
- 16
- Registration Number
- NCT01085695
Comparison of Ulcer Healing in Patients Taking Rabeprazole With Different Antiplatelets
- Conditions
- Duodenal UlcerGastric Ulcer
- Interventions
- First Posted Date
- 2009-12-23
- Last Posted Date
- 2010-06-08
- Lead Sponsor
- Taipei Veterans General Hospital, Taiwan
- Target Recruit Count
- 200
- Registration Number
- NCT01037491
- Locations
- 🇨🇳
Taipei Veterans General Hospital, Taipei, Taiwan
Practice and Patient Compliance on the PPI (Proton Pump Inhibitors) Treatment of Gastroesophageal Reflux in South Korea
- First Posted Date
- 2009-11-23
- Last Posted Date
- 2014-04-28
- Lead Sponsor
- Janssen Korea, Ltd., Korea
- Target Recruit Count
- 1197
- Registration Number
- NCT01018160
Drug Development Updates
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