Glycerin

Overview

A trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism.

Indication

It is used as a solvent, emollient, pharmaceutical agent, and sweetening agent.

Associated Conditions

Cold Sore
Constipation
Dry Mouth
Dry Skin
Dry throat
Edema of the cerebrum
Increase in Intracranial Pressure (ICP)
Occasional Constipation
Ocular Discomfort
Ocular Hypertension
Ocular Irritation
Skin Infections
Sore Throat
Mouth soreness
Sensation of burning in the eyes

Clinical Trials

Title	Posted	Study ID	Phase	Status	Sponsor
Lactate and Glycerol Contribution to Gluconeogenesis	2025/05/02	NCT06955130	Phase 1	Not yet recruiting	Rutgers, The State University of New Jersey
The Effect of Sublingual Nitroglycerin on Absolute Coronary Blood Flow	2025/03/25	NCT06823843	Phase 4	Completed	VZW Cardiovascular Research Center Aalst
Efficacy and Safety of the Treatment of Pyruvate Dehydrogenase Deficiency Patients With Glycerol Phenylbutyrate (RAVICTI)	2025/03/20	NCT06887777	Phase 2	Not yet recruiting	Assistance Publique - Hôpitaux de Paris
Lactoferrin Effect on Kidney and Heart of Rhabdomyolysis Rats	2024/07/09	NCT06491394	Phase 4	Completed	Aswan University Hospital
Saline Enema Administration in Meconium Obstruction of Prematurity and Impact on the Resolution, Feeds, Microbiome, and Gut-brain Axis.	2023/09/21	NCT06048614	Not Applicable	Recruiting	KK Women's and Children's Hospital
Evaluation of Fecal Microbiome Changes After Antegrade Continence Enema Placement and Initiation of Bowel Flush Regimen	2023/04/20	NCT05821309	Phase 4	Recruiting	Indiana University
A Multi-Center Study on the Use of Rho-Kinase Inhibitor to Reduce or Prevent PVR in RRD Eyes at High Risk for PVR	2022/12/21	NCT05660447	Phase 2	Active, not recruiting	Wills Eye
Evaluation of the Tolerability and Efficacy of CWT-f-002 Lubricant Eye Drops	2022/12/21	NCT05660681	Not Applicable	Completed	Calm Water Therapeutics LLC
The Effects of Glycerol as an Optical Clearing Agent for Visualization of the Middle Ear	2022/08/11	NCT05497934	Phase 1	Withdrawn	Nova Scotia Health Authority
Glycerol-Phenylbutyrate Treatment in Children With MCT Mutation (Allan-Herndon- Dudley Syndrome)	2021/08/24	NCT05019417	Phase 2	UNKNOWN	Kaplan Medical Center

FDA Drug Approvals

Approved Product	Manufacturer	NDC Code	Route	Strength	Effective Date
Sterile Diluent for Allergenic Extract	Antigen Laboratories, Inc.	49288-9932	INTRADERMAL, SUBCUTANEOUS	0.1 mL in 1 mL	12/8/2009
Exchange Select Maximum Redness Relief Eye Drops	Army and Air Force Exchange Service	55301-998	OPHTHALMIC	0.5 g in 100 mL	1/1/2024
Sterile Diluent for Allergenic Extract	Antigen Laboratories, Inc.	49288-9936	INTRADERMAL, SUBCUTANEOUS	0.25 mL in 1 mL	12/8/2009
Harris Teeter Redness Relief Eye Drops	Harris Teeter, LLC.	69256-979	OPHTHALMIC	0.25 g in 100 mL	1/1/2024
Sterile Diluent for Allergenic Extract	Antigen Laboratories, Inc.	49288-9935	INTRADERMAL, SUBCUTANEOUS	0.5 mL in 1 mL	12/8/2009
CVS Pharmacy Glycerin Laxative	CVS Pharmacy	59779-109	RECTAL	2 g in 1 1	7/13/2025
Liquid Glycerin Laxatives	Shanghai Yijing Medical Technology Co., Ltd.	85157-002	RECTAL	7.2 g in 10 mL	2/19/2025
Equaline Redness Relief Lubricant Eye Drops	United Natural Foods, Inc	83455-213	OPHTHALMIC	0.25 g in 100 mL	1/1/2024
HYDRASPHERE PLUS	HYDRASPHERE PLUS LLC	85579-005	CUTANEOUS	1 g in 40 mL	4/28/2025
SUKKHI Polyamino Sugar Condensate Massage Cream	GUANGZHOU YUSONG FINE CHEMICLS Co., Ltd	84558-008	CUTANEOUS	4 g in 100 g	5/7/2025

EMA Drug Approvals

Approved Product	Authorization Holder	Status	Issued Date
No EMA approvals found for this drug.

HSA Drug Approvals

Approved Product	Manufacturer	Approval Number	Dosage Form	Strength	Approval Date
GLYCEROL 2G SUPPOSITORIES FOR CHILDREN	MARTINDALE PHARMACEUTICALS, Ricesteele Manufacturing Limited	SIN02823P	SUPPOSITORY	1.4 g	5/22/1989
MINICA S ENEMA	Yukinomoto Honten CO., LTD	SIN03514P	ENEMA	12.5% w/w	6/15/1989
HUACHI ENEMA	JEN SHENG PHARMACEUTICAL CO LTD	SIN02959P	ENEMA	6 g/20 ml	5/26/1989
LEMON SWEET PURGATIVE SYRUP	SYARIKAT WEN KEN DRUG SDN BHD	SIN02748P	SYRUP	1.1%	5/9/1989
KABIVEN EMULSION FOR INFUSION	FRESENIUS KABI AB, FRESENIUS KABI AUSTRIA GMBH	SIN11657P	INJECTION	4.3 g/1000 ml	9/4/2001
LIPOFUNDIN MCT/LCT INFUSION 20%	B BRAUN MELSUNGEN AG	SIN05658P	INJECTION	25 g/1000 ml	4/8/1991

NMPA Drug Approvals

Approved Product	Company	Approval Number	Drug Type	Dosage Form	Approval Date
No NMPA approvals found for this drug.

PPB Drug Approvals

Approved Product	Registration No.	Company	Licence No.	Strength	Registration Date
GVSOFT ADULT SUPPOSITORIES 70% W/W	N/A	WELL FAVOURED LIMITED	N/A	N/A	1/15/2025
GVSOFT CHILD SUPPOSITORIES 70% W/W	N/A	WELL FAVOURED LIMITED	N/A	N/A	1/15/2025
SHUN BINLING ENEMA	N/A	BEST UNITED MARKETING LIMITED	N/A	N/A	3/16/2012
LUBRICARE ENEMA 43% W/V	N/A	EUROPHARM LABORATOIRES COMPANY LIMITED	N/A	N/A	6/3/2020
PERSTON ENEMA	N/A	EUROPHARM LABORATOIRES COMPANY LIMITED	N/A	N/A	4/26/2001
CLYSTER JEN SHENG ENEMA	N/A	LANWAY LIMITED	N/A	N/A	6/24/1997
QUIKCECOL ENEMA 43% W/V	N/A	EUROPHARM LABORATOIRES COMPANY LIMITED	N/A	N/A	6/3/2020

TGA Drug Approvals

Approved Product	ARTG ID	Sponsor	Registration Type	Status	Registration Date
ORAPLEX COLD SORE GEL	39772	Petrus Pharmaceuticals Pty Ltd	Medicine	A	4/27/1992
QV DERMCARE ECZEMA FLARE UP CREAM	387944	Ego Pharmaceuticals Pty Ltd	Medicine	A	5/4/2022
EGO EMOLLIENT cream tube	10629	Ego Pharmaceuticals Pty Ltd	Medicine	A	8/2/1991
EGO EMOLLIENT cream jar	11618	Ego Pharmaceuticals Pty Ltd	Medicine	A	8/2/1991
PHARMACY SELECT BABY TEETHING GEL tube	39770	Petrus Pharmaceuticals Pty Ltd	Medicine	A	4/27/1992
PETRUS GLYCEROL 1.4g SUPPOSITORIES FOR CHILDREN strip pack	12788	Petrus Pharmaceuticals Pty Ltd	Medicine	A	8/28/1991
Kenkay Dry Skin Body Wash	323609	Actor Pharmaceuticals Pty Ltd	Medicine	A	9/16/2019
KenKay Extra Relief Hand Balm	374989	Actor Pharmaceuticals Pty Ltd	Medicine	A	9/21/2021
Magnoplasm Paste	29623	Mayne Pharma International Pty Ltd	Medicine	A	10/25/1991
Resurge Recovery Performance Moisturiser	449225	Resurge Recovery Pty Ltd	Medicine	A	5/21/2024

Health Canada Drug Approvals

Approved Product	Company	DIN	Dosage Form	Strength	Market Date
GLY-RECTAL SUP POUR ENFANTS	lab valmo enregistré, division of technilab inc.	N/A	Suppository - Rectal	91 % / SUP	12/31/1979
VISINE CONTACT LENS	johnson & johnson inc	02229483	Drops - Ophthalmic	0.2 %	8/24/1998
CLEAR EYES EXTRA STRENGTH REDNESS RELIEF	prestige brands inc	02360837	Solution - Ophthalmic	0.50 % / W/V	4/27/2011
LUBRICANT EYE DROPS	kc pharmaceuticals inc	02455579	Solution - Ophthalmic	0.2 % / W/V	N/A
DRY EYE TEARS	juno otc inc	02389886	Solution - Ophthalmic	0.2 % / W/V	2/12/2014
OPTREX EYE DROPS	schering-plough healthcare products canada, a division of schering canada inc.	02236576	Drops - Ophthalmic	1 %	8/20/1998
THERAPEUTIC HAND CREAM	e.t. browne drug co., inc.	02253399	Cream - Topical	27.6 %	N/A
OPTREX EYE DROPS	knoll pharma inc.	02185482	Drops - Ophthalmic	1 %	12/31/1996
GLYCERINUM-INJEEL LIQ (10D,30D,200D/1.1ML)	Biologische Heilmittel Heel Gmbh	02058324	Liquid - Oral	10 D / 1.1 ML	12/31/1993
REFRESH OPTIVE FUSION SENSITIVE	Allergan, Inc.	02450534	Solution - Ophthalmic	1 % / W/V	4/26/2016

CIMA AEMPS Drug Approvals

Approved Product	Company	Registration Number	Pharmaceutical Form	Prescription Type	Status
No CIMA AEMPS (Spain) approvals found for this drug.

Philippines FDA Drug Approvals

Approved Product	Company	License Number	Dosage Form	Strength	Approval Date
No Philippines FDA approvals found for this drug.

Saudi SFDA Drug Approvals

Approved Product	Company	License Number	Dosage Form	Strength	Approval Date
No Saudi SFDA approvals found for this drug.

Malaysia NPRA Drug Approvals

Approved Product	Company	Registration Number	Dosage Form	Strength	Approval Date
No Malaysia NPRA approvals found for this drug.

UK EMC Drug Information

Medicine Name	MA Holder	MA Number	Pharmaceutical Form	Active Ingredient	Authorization Date
No UK EMC drug information found for this drug.

Related News

Vantage Secures FDA Drug Master File for VYCERIN™ API Glycerin, Enhancing Pharmaceutical Formulation Options

5 months ago

Vantage Specialty Chemicals has successfully listed its VYCERIN™ API Glycerin, USP on the FDA Drug Master File (DMF-040171), offering a first-to-market pharmaceutical-grade glycerin manufactured in the United States to ICH Q7 standards.

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