Sugammadex

Generic Name
Sugammadex
Brand Names
Bridion, Sugammadex Adroiq, Sugammadex Amomed, Sugammadex Fresenius Kabi, Sugammadex Mylan, Sugammadex Piramal
Drug Type
Small Molecule
Chemical Formula
C72H112O48S8
CAS Number
343306-71-8
Unique Ingredient Identifier
361LPM2T56
Background

Sugammadex is a selective relaxant binding agent indicated for reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide during surgery. Rocuronium bromide and vecuronium bromide are neuromuscular blocking medications that cause temporary paralysis and are especially useful for general anesthesia, ventilation, or tracheal intubation that patients may require for surgery. Sugammadex provides a new treatment option to reverse the effects of those medications and possibly help patients recover sooner post-surgery. Sugammadex (brand name Bridion) is marketed by Merck Sharp and Dohme, and was approved by the United States FDA on December 15, 2015.

Indication

Sugammadex is indicated for the reversal of neuromuscular blockade induced by rocuronium bromide or vecuronium bromide in adults and pediatric patients ≥2 years old who are undergoing surgery.

Associated Conditions
Neuromuscular blockade caused by vecuronium bromide
Associated Therapies
-

Sugammadex/Neostigmine and Liver Transplantation

First Posted Date
2016-03-03
Last Posted Date
2021-09-21
Lead Sponsor
Azienda Ospedaliera S. Maria della Misericordia
Target Recruit Count
40
Registration Number
NCT02697929
Locations
🇮🇹

AOU Santa Maria della Misericordia, Udine, Italy

Sugammadex Versus Neostigmine for Postoperative Nausea and Vomiting After Laparoscopic Gynaecological Surgery

First Posted Date
2016-01-28
Last Posted Date
2018-06-28
Lead Sponsor
KK Women's and Children's Hospital
Target Recruit Count
184
Registration Number
NCT02666014
Locations
🇸🇬

KK Women's and Children's Hospital, Singapore, Singapore

The Effect of Deep Neuromuscular Block on Surgical Condition During Laparoscopic Colorectal Surgery

Phase 4
Completed
Conditions
Interventions
First Posted Date
2015-10-20
Last Posted Date
2019-03-13
Lead Sponsor
Seoul National University Bundang Hospital
Target Recruit Count
70
Registration Number
NCT02580188

Effect of Dexamethasone on the Action of Sugammadex

First Posted Date
2015-07-29
Last Posted Date
2016-10-04
Lead Sponsor
Attikon Hospital
Target Recruit Count
44
Registration Number
NCT02510157
Locations
🇬🇷

2nd Department of Anesthesiology, Attikon Hospital, 1 Rimini str., Athens, Greece

Can Adequacy of Anesthesia Depth and Quality of Recovery be Influenced by the Level of Neuromuscular Blockade?

Phase 4
Completed
Conditions
Interventions
First Posted Date
2015-06-29
Last Posted Date
2019-09-16
Lead Sponsor
Centro Hospitalar do Porto
Target Recruit Count
70
Registration Number
NCT02484651
Locations
🇵🇹

Centro Hospitalar do Porto, Porto, Portugal

Neuromuscular Blockade Reversal Agent Effect on Postoperative Cognitive Function and Behaviour in Children

First Posted Date
2015-05-28
Last Posted Date
2018-10-24
Lead Sponsor
Attikon Hospital
Target Recruit Count
200
Registration Number
NCT02455921
Locations
🇬🇷

2nd Department of Anesthesiology, Attikon University Hospital, Athens, Attiki, Greece

Quality of Awakening and Impact on Cognitive Function After Administration of Sugammadex in Robotic Radical Cystectomy

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2015-05-27
Last Posted Date
2018-08-31
Lead Sponsor
Regina Elena Cancer Institute
Target Recruit Count
120
Registration Number
NCT02454504
Locations
🇮🇹

Regina Elena Cancer Institute, Rome, RM, Italy

Sugammadex and Cognitive Function

First Posted Date
2015-04-17
Last Posted Date
2020-04-13
Lead Sponsor
Attikon Hospital
Target Recruit Count
160
Registration Number
NCT02419352
Locations
🇬🇷

2nd Department of Anesthesiology, Attikon Hospital, 1 Rimini str., Athens, Greece

Sugammadex Versus Neostigmine in Patients With Liver Cirrhosis Undergoing Liver Resection

First Posted Date
2015-04-13
Last Posted Date
2016-02-02
Lead Sponsor
Cairo University
Target Recruit Count
60
Registration Number
NCT02414880
Locations
🇪🇬

National Liver institute, Garden City, Cairo, Egypt

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