Tropisetron
- Generic Name
- Tropisetron
- Drug Type
- Small Molecule
- Chemical Formula
- C17H20N2O2
- CAS Number
- 89565-68-4
- Unique Ingredient Identifier
- 6I819NIK1W
- Background
Tropisetron is an indole derivative with antiemetic activity. As a selective serotonin receptor antagonist, tropisetron competitively blocks the action of serotonin at 5HT3 receptors, resulting in suppression of chemotherapy- and radiotherapy-induced nausea and vomiting.
Tropisetron appears to be well tolerated with the most frequently reported adverse effect being headache. Extrapyramidal side effects are rare upon using tropisetron.
- Indication
For the prevention of nausea and vomiting induced by cytotoxic therapy and postoperative.
- Associated Conditions
- Chemotherapy-Induced Nausea and Vomiting
The Central Analgesic Effects of Paracetamol on Serotonergic Pathways
- Conditions
- Analgesia
- Interventions
- First Posted Date
- 2009-09-02
- Last Posted Date
- 2013-01-29
- Lead Sponsor
- University Hospital, Basel, Switzerland
- Target Recruit Count
- 16
- Registration Number
- NCT00970450
- Locations
- 🇨🇭
University Hospital of Basel, Basel, Switzerland
Modulation of Central Hypersensitivity in Chronic Musculoskeletal Pain by Intravenous Tropisetron
- Conditions
- PainChronic Disease
- Interventions
- First Posted Date
- 2009-04-29
- Last Posted Date
- 2011-03-24
- Lead Sponsor
- Insel Gruppe AG, University Hospital Bern
- Target Recruit Count
- 30
- Registration Number
- NCT00889499
- Locations
- 🇨🇭
Dep. of Anesthesiology and Pain Therapy, Bern University Hospital, Inselspital, Bern, Switzerland
Clinical Confirmation of a Pharmacodynamic Interaction Between Tropisetron and Paracetamol
- Conditions
- Pain
- First Posted Date
- 2007-06-15
- Last Posted Date
- 2010-03-29
- Lead Sponsor
- University Hospital, Clermont-Ferrand
- Target Recruit Count
- 40
- Registration Number
- NCT00487110
- Locations
- 🇫🇷
CHU, Clermont-Ferrand, France
Effectiveness of Tropisetron Plus Risperidone for Improving Cognitive and Perceptual Disturbances in Schizophrenia
- Conditions
- Smoking CessationSchizophrenia
- Interventions
- First Posted Date
- 2007-02-14
- Last Posted Date
- 2017-03-15
- Lead Sponsor
- Baylor College of Medicine
- Target Recruit Count
- 179
- Registration Number
- NCT00435370
- Locations
- 🇨🇳
Beijing Hui-Long Guan Hospital, Beijing, China
🇺🇸Baylor College of Medicine - Michael E. DeBakey VA Medical Center, Houston, Texas, United States
Acupressure and Acustimulation Wrist Bands for the Prevention of Nausea and Vomiting Caused by Chemotherapy
- Conditions
- Nausea and VomitingUnspecified Adult Solid Tumor, Protocol Specific
- First Posted Date
- 2004-03-23
- Last Posted Date
- 2015-10-15
- Lead Sponsor
- Gary Morrow
- Target Recruit Count
- 700
- Registration Number
- NCT00003817
- Locations
- 🇺🇸
Hackensack University Medical Center, Hackensack, New Jersey, United States
🇺🇸University of Rochester Cancer Center, Rochester, New York, United States
Drug Development Updates
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