Potassium chloride

Generic Name: Potassium chloride

Brand Names: Bi-peglyte, Bss, Bss Ophthalmic Solution, Cardioplegic, Citrasate, Colyte, Dextrose and Electrolyte No. 75, Diphen, Eye Stream, Gavilyte-C, Gavilyte-G, Gavilyte-H and Bisacodyl, Gavilyte-N, Glycerolyte 57, Golytely, H.E.L.P.bicel, Hemosate Ultra, Ionosol-MB, Isolyte P, Isolyte S, Isolyte S pH 7.4, Isoplate, K 45, K-tab, Klor-con, Lactated Ringers, Moviprep, Naturalyte, Normosol-R, Nulytely, Nxstage Pureflow, Olimel, Peglyte, Periolimel, Phoxillum, Physiolyte, Physiosol, Plasma-lyte, Plasma-lyte 148, Plasma-lyte 148 In 5 % Dextrose, Plasma-lyte R, Plasmalyte A, Plegisol, Plenvu, Pokonza, Prismasol, Procalamine 3, Ringers, Selectbag One, Suflave, Tis-U-sol

Drug Type: Small Molecule

Chemical Formula: ClK

CAS Number: 7447-40-7

Unique Ingredient Identifier: 660YQ98I10

Background: A white crystal or crystalline powder used as an electrolyte replenisher, in the treatment of hypokalemia, in buffer solutions, and in fertilizers and explosives.

The FDA withdrew its approval for the use of all solid oral dosage form drug products containing potassium chloride that supply 100 mg or more of potassium per dosage unit, except for controlled-release dosage forms and those products formulated for preparation of solution prior to ingestion.

Indication: For use as an electrolyte replenisher and in the treatment of hypokalemia.

Associated Conditions: Dehydration, Dry Mouth, Hypokalemia, Hypotonic Dehydration, Hypovolaemia, Isotonic Dehydration, Markedly Reduced Food Intake, Metabolic Acidosis, Hypodermoclysis, Mild Metabolic acidosis, Mild, moderate Metabolic Acidosis, Ocular edema

Associated Therapies: Acid- Base Balance, Bowel preparation therapy, Electrolyte replacement, Fluid replacement therapy, Haemofiltration, Hemodialysis Treatment, Parenteral Nutrition, Parenteral rehydration therapy, Plasma Volume Replacement, Urine alkalinization therapy, Fluid and electrolyte maintenance therapy

Clinical Trials

A Double Blind Study Comparing Hyaluronic Acid, Corticosteroid and Placebo During Arthrocentesis for Temporomandibular Joint (TMJ) Dysfunction

Phase 4

Completed

Conditions: Temporomandibular Joint Dysfunction
Arthrocentesis
Pain

Interventions: Drug: Corticosteroid
Drug: Lactated Ringers
Drug: Hyaluronic acid

First Posted Date: 2012-02-02

Last Posted Date: 2017-05-05

Lead Sponsor: Emory University

Target Recruit Count: 102

Registration Number: NCT01524913

Locations: 🇺🇸
University of Cinncinati, Cinncinati, Ohio, United States
🇺🇸
University California Los Angeles, Los Angeles, California, United States
🇺🇸
Emory University, Atlanta, Georgia, United States

and more 2 locations

The Use of a Restrictive Fluid Regimen With Hypertonic Saline for Patients Undergoing Pancreaticoduodenectomy

Phase 2

Conditions: Pancreaticoduodenectomy

Interventions: Drug: 3% NaCl Solution
Drug: Lactated Ringers Solution

First Posted Date: 2011-09-02

Last Posted Date: 2015-03-18

Lead Sponsor: Thomas Jefferson University

Target Recruit Count: 264

Registration Number: NCT01428050

Locations: 🇺🇸
Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States

Pertubation With Lignocaine in Endometriosis

Phase 2

Completed

Conditions: Endometriosis
Dysmenorrhea

Interventions: Drug: Ringers Solution
Drug: Lignocaine

First Posted Date: 2011-04-06

Last Posted Date: 2011-04-06

Lead Sponsor: Isifer AB

Target Recruit Count: 42

Registration Number: NCT01329796

Locations: 🇸🇪
Läkargruppen Victoria Söderhallarna 120, Stockholm, Sweden
🇸🇪
Karolinska Institute, Fertility Unit, K59 Karolinska University Hospital at Huddinge, Stockholm, Sweden
🇸🇪
Department of Gynaecology and Obstetrics Danderyd Hospital, Stockholm, Sweden

Miralax (PEG 3350) vs. Golytely as Bowel Preparation for Screening Colonoscopy

Phase 4

Completed

Conditions: Colon Cancer

Interventions: Drug: PEG-3350 and Gatorade
Drug: Golytely 4 liters

First Posted Date: 2010-07-27

Last Posted Date: 2017-09-13

Lead Sponsor: Temple University

Target Recruit Count: 136

Registration Number: NCT01170754

Locations: 🇺🇸
Temple University Hospital, Philadelphia, Pennsylvania, United States

Comparison of Two Potassium Targets Within the Normal Range in Intensive Care Patients

Phase 4

Completed

Conditions: Thoracic Surgery
Cardiac Surgery
Critically Ill

Interventions: Drug: Potassium Chloride

First Posted Date: 2010-03-11

Last Posted Date: 2013-01-21

Lead Sponsor: University Medical Center Groningen

Target Recruit Count: 1225

Registration Number: NCT01085071

Locations: 🇳🇱
University Medical Center Groningen, University of Groningen, Groningen, Netherlands

Potassium-Magnesium Citrate as a Blood Pressure Lowering Agent in Hypertensive Patients

Phase 1

Withdrawn

Conditions: Pre-hypertension
Hypertension

Interventions: Drug: Potassium, Magnesium, Citrate
Drug: Potassium Chloride

First Posted Date: 2010-02-24

Last Posted Date: 2019-02-11

Lead Sponsor: University of Texas Southwestern Medical Center

Registration Number: NCT01074918

Locations: 🇺🇸
Dallas VA Medical Center, Dallas, Texas, United States
🇺🇸
UT Southwestern Medical Center, Dallas, Texas, United States

Gatorade/Miralax With or Without Bisacodyl Versus NuLytely for Colonoscopy Preparation

Phase 4

Completed

Conditions: Preparation for Colonoscopy

Interventions: Drug: Gatorade/Miralax
Drug: NuLytely
Drug: Placebo
Drug: Bisacodyl

First Posted Date: 2010-02-05

Last Posted Date: 2013-11-18

Lead Sponsor: Gastroenterology Services, Ltd.

Target Recruit Count: 600

Registration Number: NCT01063049

Locations: 🇺🇸
Gastroenterology Services, Downers Grove, Illinois, United States

Phase IIa Study of MP4OX in Traumatic Hemorrhagic Shock Patients

Phase 2

Completed

Conditions: Shock, Hemorrhagic
Shock, Traumatic
Acidosis, Lactic

Interventions: Drug: MP4OX
Drug: Ringers Lactate solution

First Posted Date: 2009-10-29

Last Posted Date: 2013-08-19

Lead Sponsor: Sangart

Target Recruit Count: 51

Registration Number: NCT01004198

Locations: 🇫🇷
Hôpital Pitié-Salpêtrière, Paris, France
🇿🇦
Netcare Milpark Hospital, Johannesburg, South Africa
🇫🇷
Centre Hospitalier de Bicêtre, Le Kremlin Bicetre, France

and more 10 locations

Scandinavian Starch for Severe Sepsis/Septic Shock Trial

Phase 3

Completed

Conditions: Severe Sepsis
Septic Shock

Interventions: Drug: 6% Hydroxyethyl starch 130/0.4
Drug: Ringers acetate

First Posted Date: 2009-08-19

Last Posted Date: 2012-07-10

Lead Sponsor: Anders Perner

Target Recruit Count: 804

Registration Number: NCT00962156

Locations: 🇳🇴
St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway
🇩🇰
Hjørring Hospital, Hjørring, Denmark
🇩🇰
Holstebro Hospital, Holstebro, Denmark

and more 23 locations

A Trial Comparing Split-Dose Miralax With Amitiza Pretreatment Versus Dulcolax Pretreatment Versus Golytely for Bowel Cleansing Prior to Colonoscopy

Phase 4

Completed

Conditions: Colonoscopy

Interventions: Drug: Amitiza (Lubiprostone)
Drug: Dulcolax (Bisacodyl)
Drug: Miralax (PEG 3350)
Drug: Golytely (polyethylene glycol)

First Posted Date: 2009-08-06

Last Posted Date: 2012-11-30

Lead Sponsor: Brooke Army Medical Center

Target Recruit Count: 425

Registration Number: NCT00953017

Locations: 🇺🇸
Brooke Army Medical Center, San Antonio, Texas, United States

Drug Development Updates

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