Monomethyl fumarate

Generic Name: Monomethyl fumarate

Brand Names: Bafiertam

Drug Type: Small Molecule

Chemical Formula: C_₅H_₆O_₄

CAS Number: 2756-87-8

Unique Ingredient Identifier: 45IUB1PX8R

Clinical Trials

Prospective Donor Specific T Response Measurment for IS Minimization in de Novo Renal Transplantation

Not Applicable

Completed

Conditions: Effects of Immunosuppressant Therapy
Disorder Related to Renal Transplantation

Interventions: Drug: Tacrolimus (for Group B)
Drug: Tacrolimus (for Group A)
Drug: MMF (mycophenolate mofetil) (for Group B)
Drug: Mycofenolate mofetil (MMF) (for Group A)
Drug: 6-methyl prednisolone (Steroids) (for Group A)
Drug: 6-methyl prednisolone (Steroids) (for Group B)

First Posted Date: 2015-09-04

Last Posted Date: 2021-02-01

Lead Sponsor: Prof. Dr. Petra Reinke

Target Recruit Count: 184

Registration Number: NCT02540395

Locations: 🇪🇸
Hospital Universitari de Bellvitge, Hospitalet de Llobregat, Barcelona, Spain
🇩🇪
Department Nephrology and BCRT, Charité Universitätsmedizin Berlin, Berlin, Germany
🇬🇧
Guy's Hospital, Great Maze Pond, London, United Kingdom

and more 5 locations

Randomized Trial Comparing Rituximab Against Mycophenolate Mofetil in Children Wtih Refractory Nephrotic Syndrome

Phase 3

Terminated

Conditions: Frequent Relapsing Nephrotic Syndrome
Steroid Dependent Nephrotic Syndrome

Interventions: Drug: Rituximab
Drug: MMF

First Posted Date: 2015-03-17

Last Posted Date: 2019-03-26

Lead Sponsor: Nationwide Children's Hospital

Target Recruit Count: 3

Registration Number: NCT02390362

Locations: 🇺🇸
Nationwide Children's Hospital, Columbus, Ohio, United States

The Impact of Everolimus Based Immunosuppression in the Evolution of Hepatitis C Fibrosis After Liver Transplantation

Phase 3

Completed

Conditions: Hepatitis C Recurrence After Liver Transplant

Interventions: Drug: MMF arm
Drug: EVL arm

First Posted Date: 2012-10-16

Last Posted Date: 2018-02-07

Lead Sponsor: Hospital Vall d'Hebron

Target Recruit Count: 18

Registration Number: NCT01707849

Locations: 🇪🇸
Department of HPB Surgery and Transplant, Hospital Vall d´Hebron, Barcelona, Spain

Efficacy, Tolerability and Safety of Early Introduction of Everolimus, Reduced Calcineurin Inhibitors and Early Steroid Elimination Compared to Standard CNI, Mycophenolate Mofetil and Steroid Regimen in Paediatric Renal Transplant Recipients

Phase 3

Completed

Conditions: Prevention of Acute Rejection in Paediatric Recipients of a Renal Transplant

Interventions: Drug: RAD001
Drug: MMF

First Posted Date: 2012-03-06

Last Posted Date: 2019-05-31

Lead Sponsor: Novartis Pharmaceuticals

Target Recruit Count: 106

Registration Number: NCT01544491

Locations: 🇬🇧
Novartis Investigative Site, Nottingham, United Kingdom

Optimization of NULOJIX® Usage As A Means of Avoiding CNI and Steroids in Renal Transplantation

Phase 2

Terminated

Conditions: Kidney Transplantation
Renal Transplantation

Interventions: Drug: Alemtuzumab
Drug: MMF
Biological: Basiliximab
Biological: Belatacept
Drug: Short-term Tac
Drug: tacrolimus
Drug: methylprednisolone

First Posted Date: 2011-09-19

Last Posted Date: 2017-09-27

Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Target Recruit Count: 19

Registration Number: NCT01436305

Locations: 🇺🇸
University of Alabama, Birmingham, Alabama, United States
🇺🇸
Emory University, Atlanta, Georgia, United States
🇺🇸
University of California San Francisco, San Francisco, California, United States

Research Study of ATG and Rituximab in Renal Transplantation

Early Phase 1

Terminated

Conditions: Renal Transplant Recipients

Interventions: Drug: ATG
Drug: Rituximab
Drug: Tacrolimus
Drug: Sirolimus
Drug: MMF

First Posted Date: 2011-03-21

Last Posted Date: 2018-11-29

Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Target Recruit Count: 10

Registration Number: NCT01318915

Locations: 🇺🇸
University of California San Francisco Medical Center, San Francisco, California, United States
🇺🇸
University of Maryland Medical Center, Baltimore, Maryland, United States
🇺🇸
Rogosin Institute/New York Presbyterian-Cornell, New York, New York, United States

and more 3 locations

A Pharmacokinetic Study of CellCept (Mycophenolate Mofetil) Versus Mycophenolate Sodium in Kidney Transplant Patients

Phase 4

Completed

Conditions: Kidney Transplantation

Interventions: Drug: EC-MPS
Drug: MMF
Drug: Prednisone

First Posted Date: 2009-12-17

Last Posted Date: 2015-08-27

Lead Sponsor: Hoffmann-La Roche

Target Recruit Count: 23

Registration Number: NCT01033864

Tacrolimus/Sirolimus/Methotrexate vs Tacrolimus/Methotrexate or Cyclosporine/Mycophenolate Mofetil for GVHD Prophylaxis After Reduced Intensity Allogeneic Stem Cell Transplantation for Patients With Lymphoma

Phase 3

Completed

Conditions: Hodgkin Lymphoma
Non-hodgkin Lymphoma

Interventions: Drug: Sirolimus
Drug: Methotrexate
Drug: Tacrolimus
Drug: Cyclosporine
Drug: MMF

First Posted Date: 2009-06-25

Last Posted Date: 2019-02-01

Lead Sponsor: Dana-Farber Cancer Institute

Target Recruit Count: 139

Registration Number: NCT00928018

Locations: 🇺🇸
Emory University Hospital, Atlanta, Georgia, United States
🇺🇸
Dana-Farber Cancer Institute, Boston, Massachusetts, United States
🇺🇸
Massachusetts General Hospital, Boston, Massachusetts, United States

and more 2 locations

Minimizing Immunosuppression in Old for Old Kidney Transplantation

Phase 4

Completed

Conditions: Kidney Transplantation

Interventions: Drug: MMF (Cellcept) and Steroids
Drug: Tacrolimus (Prograf)

First Posted Date: 2009-06-03

Last Posted Date: 2009-06-03

Lead Sponsor: University of Luebeck

Target Recruit Count: 90

Registration Number: NCT00912678

Locations: 🇩🇪
Charite- Transplant Center - Campus Mitte, Berlin, Germany
🇩🇪
Charite - Transplant Center - Virchow Clinic, Berlin, Germany
🇩🇪
University of Luebeck, Transplant Center, Luebeck, Germany

and more 2 locations

Benefit of Early Protocol Biopsy and Treatment of Subclinical Rejection

Phase 4

Completed

Conditions: Kidney Transplantation

Interventions: Drug: Tacrolimus
Drug: MMF
Drug: Corticosteroids (Prednisone)

First Posted Date: 2009-04-22

Last Posted Date: 2014-09-18

Lead Sponsor: Astellas Pharma Inc

Target Recruit Count: 240

Registration Number: NCT00885820

Drug Development Updates

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