Amoxicillin
- Generic Name
- Amoxicillin
- Brand Names
- Amoxil, Augmentin, Clavulin, Moxatag, Omeclamox, Prevpac, Talicia, Voquezna 14 Day Dualpak 20;500, Voquezna 14 Day Triplepak 20;500;500
- Drug Type
- Small Molecule
- Chemical Formula
- C16H19N3O5S
- CAS Number
- 26787-78-0
- Unique Ingredient Identifier
- 9EM05410Q9
- Background
Amoxicillin, or BRL-2333, is a penicillin G derivative first described in the literature in 1972. Amoxicillin has similar activity to penicillin and ampicillin, but leads to higher serum concentrations than ampicillin.
Amoxicillin was granted FDA approval on 18 January 1974.
- Indication
Amoxicillin alone is indicated to treat susceptible bacterial infections of the ear, nose, throat, genitourinary tract, skin, skin structure, and lower respiratory tract. Amoxicillin is given with calvulanic acid to treat acute bacterial sinusitis, community acquired pneumonia, lower respiratory tract infections, acute bacterial otitis media, skin and skin structure infections, and urinary tract infections. Amoxicillin is given with omeprazole in the treatment of Helicobacter pylori (H. pylori) infection.
Amoxicillin is used in combination with vonoprazan and clarithromycin as co-packaged triple therapy or in combination with vonoprazan as co-packaged dual therapy to treat H. pylori infection in adults.
- Associated Conditions
- Acute Bacterial Sinusitis (ABS), Acute Otitis Media (AOM), Bacterial Infections, Community Acquired Pneumonia (CAP), Duodenal ulcer caused by helicobacter pylori, Genitourinary tract infection, Helicobacter Pylori Infection, Lower Respiratory Tract Infection (LRTI), Peptic Ulcer With H. Pylori Infection, Sinusitis, Skin and Subcutaneous Tissue Bacterial Infections, Urinary Tract Infection, Acute, uncomplicated Gonorrhea, Ear, nose, and throat infections
- Associated Therapies
- -
3 Days Amoxicillin Versus Placebo for Fast Breathing Childhood Pneumonia in Malawi
- First Posted Date
- 2016-05-03
- Last Posted Date
- 2021-02-18
- Lead Sponsor
- Save the Children
- Target Recruit Count
- 1126
- Registration Number
- NCT02760420
- Locations
- 🇲🇼
Kamuzu Central Hospital, Lilongwe, Malawi
🇲🇼Bwaila District Hospital, Lilongwe, Malawi
Dose and Duration of Metronidazole and Amoxicillin for Treatment of Chronic Periodontitis
- Conditions
- Interventions
- First Posted Date
- 2016-04-12
- Last Posted Date
- 2020-01-13
- Lead Sponsor
- University of Guarulhos
- Target Recruit Count
- 110
- Registration Number
- NCT02735395
- Locations
- 🇧🇷
Guarulhos University, Guarulhos, São Paulo, Brazil
Microbial, Immune, and Metabolic Perturbations by Antibiotics (MIME Study)
- Conditions
- Interventions
- First Posted Date
- 2016-03-14
- Last Posted Date
- 2024-12-12
- Target Recruit Count
- 210
- Registration Number
- NCT02707042
- Locations
- 🇺🇸
National Institutes of Health Clinical Center, Bethesda, Maryland, United States
Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Streptococcus
- First Posted Date
- 2016-03-08
- Last Posted Date
- 2021-05-19
- Lead Sponsor
- University Hospital, Tours
- Target Recruit Count
- 324
- Registration Number
- NCT02701595
- Locations
- 🇫🇷
Service des Maladies infectieuses et tropicales, CH Le Mans, Le Mans, France
🇫🇷Service de Réanimation médicale, Hôpital St André, CHU de Bordeaux, Bordeaux, France
🇫🇷Service de Maladies infectieuses, Hôpital de la Cavale Blanche, CHU Brest, Brest, France
The Role of Antibiotic Prophylaxis in Cleft Palate and Velopharyngeal Insufficiency Repair
- First Posted Date
- 2016-02-23
- Last Posted Date
- 2017-12-21
- Lead Sponsor
- University of Florida
- Registration Number
- NCT02688634
- Locations
- 🇺🇸
UF Health at Shands Hospital, Gainesville, Florida, United States
🇺🇸University of Florida, Gainesville, Florida, United States
3 Days Versus 5 Days Amoxicillin for Chest-indrawing Childhood Pneumonia in Malawi
- First Posted Date
- 2016-02-09
- Last Posted Date
- 2021-02-18
- Lead Sponsor
- Save the Children
- Target Recruit Count
- 3000
- Registration Number
- NCT02678195
- Locations
- 🇲🇼
Kamuzu Central Hospital, Lilongwe, Malawi
🇲🇼Bwaila District Hospital, Lilongwe, Malawi
The Pilot Study on Tailored Eradication Therapy According to Clarithromycin Resistance in H.Pylori Patients
- Conditions
- Interventions
- First Posted Date
- 2016-01-07
- Last Posted Date
- 2018-08-09
- Lead Sponsor
- Kyungpook National University Hospital
- Target Recruit Count
- 50
- Registration Number
- NCT02648659
Helicobacter Pylori Eradication With Berberine Quadruple Therapy Versus Clarithromycin Quadruple Therapy
- Conditions
- Interventions
- First Posted Date
- 2015-12-17
- Last Posted Date
- 2017-01-18
- Lead Sponsor
- Xijing Hospital of Digestive Diseases
- Target Recruit Count
- 566
- Registration Number
- NCT02633930
- Locations
- 🇨🇳
Xijing Hospital of Digestive Diseases, Xi'an, Shanxi, China
🇨🇳Xijing Hospital of Digestive Disease, Xi'an, Shanxi, China
Food Effect on the Eradication Rate of H. Pylori With Triple Therapy With Esomeprazole
- Conditions
- Interventions
- Locations
- 🇧🇷
Universidade de São Paulo, São Paulo, Brazil
Bioavailability of Paracetamol, Amoxicillin and Talinolol Before, Immediately and One Year After Gastric Bypass Operation
- First Posted Date
- 2015-08-04
- Last Posted Date
- 2015-08-04
- Lead Sponsor
- University Medicine Greifswald
- Target Recruit Count
- 12
- Registration Number
- NCT02514941
- Locations
- 🇩🇪
Surgical Clinic of the Clinical Centre Suedstadt Rostock, Rostock, Germany
🇩🇪Department of Clinical Pharmacology, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Mecklenburg-Vorpommern, Germany
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.