Amoxicillin
- Generic Name
- Amoxicillin
- Brand Names
- Amoxil, Augmentin, Clavulin, Moxatag, Omeclamox, Prevpac, Talicia, Voquezna 14 Day Dualpak 20;500, Voquezna 14 Day Triplepak 20;500;500
- Drug Type
- Small Molecule
- Chemical Formula
- C16H19N3O5S
- CAS Number
- 26787-78-0
- Unique Ingredient Identifier
- 9EM05410Q9
- Background
Amoxicillin, or BRL-2333, is a penicillin G derivative first described in the literature in 1972. Amoxicillin has similar activity to penicillin and ampicillin, but leads to higher serum concentrations than ampicillin.
Amoxicillin was granted FDA approval on 18 January 1974.
- Indication
Amoxicillin alone is indicated to treat susceptible bacterial infections of the ear, nose, throat, genitourinary tract, skin, skin structure, and lower respiratory tract. Amoxicillin is given with calvulanic acid to treat acute bacterial sinusitis, community acquired pneumonia, lower respiratory tract infections, acute bacterial otitis media, skin and skin structure infections, and urinary tract infections. Amoxicillin is given with omeprazole in the treatment of Helicobacter pylori (H. pylori) infection.
Amoxicillin is used in combination with vonoprazan and clarithromycin as co-packaged triple therapy or in combination with vonoprazan as co-packaged dual therapy to treat H. pylori infection in adults.
- Associated Conditions
- Acute Bacterial Sinusitis (ABS), Acute Otitis Media (AOM), Bacterial Infections, Community Acquired Pneumonia (CAP), Duodenal ulcer caused by helicobacter pylori, Genitourinary tract infection, Helicobacter Pylori Infection, Lower Respiratory Tract Infection (LRTI), Peptic Ulcer With H. Pylori Infection, Sinusitis, Skin and Subcutaneous Tissue Bacterial Infections, Urinary Tract Infection, Acute, uncomplicated Gonorrhea, Ear, nose, and throat infections
- Associated Therapies
- -
Effectiveness and Safety of Once or Twice Daily Mometasone Nasal Spray Versus Amoxicillin Versus Placebo for Treatment of Acute Rhinosinusitis (Phase 3 Study)(Study P02692)
- Conditions
- Acute Rhinosinusitis
- Interventions
- First Posted Date
- 2008-09-11
- Last Posted Date
- 2024-08-15
- Lead Sponsor
- Organon and Co
- Target Recruit Count
- 981
- Registration Number
- NCT00751075
Effectiveness and Safety of Once or Twice Daily Mometasone Nasal Spray Versus Amoxicillin Versus Placebo for Treatment of Acute Rhinosinusitis (Study P02683)
- Conditions
- Acute Rhinosinusitis
- Interventions
- First Posted Date
- 2008-09-11
- Last Posted Date
- 2024-08-15
- Lead Sponsor
- Organon and Co
- Target Recruit Count
- 981
- Registration Number
- NCT00750750
Assessment of Use of Rapid Diagnostic Testing in the Context of Home Management With ACTs
- Conditions
- MalariaPneumonia
- Interventions
- Drug: Artemether-lumefantrine combinationDrug: amoxycillinDrug: paracetamolDevice: malaria rapid diagnostic test, respiratory rate timer
- First Posted Date
- 2008-07-23
- Last Posted Date
- 2012-03-16
- Lead Sponsor
- Mbarara University of Science and Technology
- Target Recruit Count
- 6456
- Registration Number
- NCT00720811
- Locations
- 🇬🇭
Kassena Nankana Site, Kassana, Ghana
🇺🇬Iganga Site, Iganga, Uganda
🇧🇫Sapone Site, Sapone, Burkina Faso
A Comparison of the Safety and Efficacy of Cefdinir Oral Suspension Versus Amoxicillin/Clavulanate in Pediatric Subjects With Acute Otitis Media
- First Posted Date
- 2008-03-27
- Last Posted Date
- 2008-03-27
- Lead Sponsor
- Abbott
- Target Recruit Count
- 425
- Registration Number
- NCT00644943
A Comparative, Single-Center, Pediatric Taste Test Study of Omnicef Versus Amoxicillin Antibiotic Suspension Medications
- First Posted Date
- 2008-03-27
- Last Posted Date
- 2008-03-27
- Lead Sponsor
- Abbott
- Target Recruit Count
- 154
- Registration Number
- NCT00645125
Pediatric Taste Test Study of Cefdinir (Omnicef) Versus Amoxicillin Antibiotic Suspension Medications
- First Posted Date
- 2008-03-27
- Last Posted Date
- 2008-03-27
- Lead Sponsor
- Abbott
- Target Recruit Count
- 158
- Registration Number
- NCT00644891
Comparative Study of the Safety and Efficacy of Clarithromycin Extended-Release Tablets Versus Amoxicillin-Clavulanate for the Treatment of Acute Bacterial Sinusitis
- Conditions
- Acute Bacterial Sinusitis (ABS)
- Interventions
- First Posted Date
- 2008-03-27
- Last Posted Date
- 2008-03-27
- Lead Sponsor
- Abbott
- Target Recruit Count
- 437
- Registration Number
- NCT00644553
A Multicenter, Randomized, Double-Blind, Double-Dummy Study Of Azithromycin SR Versus Amoxicillin For The Treatment Of Strep Throat In Children
- First Posted Date
- 2008-03-26
- Last Posted Date
- 2011-05-17
- Lead Sponsor
- Pfizer
- Target Recruit Count
- 693
- Registration Number
- NCT00643149
- Locations
- 🇮🇳
Pfizer Investigational Site, Mumbai, Maharashtra, India
Long-term Antibiotics for Treatment and Prevention of Otitis Media in Aborignal Children
- Conditions
- Otitis Media
- Interventions
- Drug: AmoxycillinDrug: Placebo equivalent to amoxycillin
- First Posted Date
- 2007-10-04
- Last Posted Date
- 2010-05-24
- Lead Sponsor
- Menzies School of Health Research
- Target Recruit Count
- 126
- Registration Number
- NCT00539149
- Locations
- 🇦🇺
Menzies School of Health Research, Darwin, Northern Territory, Australia
Esomeprazole, Moxifloxacin and Amoxicilin for Rescue Therapy of Helicobacter Pylori Infection
- Conditions
- Helicobacter Pylori InfectionChronic Gastritis
- First Posted Date
- 2007-04-04
- Last Posted Date
- 2007-04-04
- Lead Sponsor
- Technische Universität Dresden
- Target Recruit Count
- 132
- Registration Number
- NCT00455806
- Locations
- 🇩🇪
Technical University of Munich, Medical Dept. II, Munich, Germany
🇩🇪Med. Department, Jung-Stilling Krankenhaus, Siegen, Germany
🇩🇪Med. Dept. I, Gastroenterology, University Hospital, Technical University of Dresden, Dresden, Germany
Drug Development Updates
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