Zoledronic acid
- Generic Name
- Zoledronic acid
- Brand Names
- Aclasta, Reclast, Zometa, Zoledronic Acid Accord, Zoledronic acid Actavis, Zoledronic acid medac, Zoledronic acid Teva, Zoledronic Acid Hospira, Zoledronic acid Mylan
- Drug Type
- Small Molecule
- Chemical Formula
- C5H10N2O7P2
- CAS Number
- 118072-93-8
- Unique Ingredient Identifier
- 70HZ18PH24
- Background
Zoledronic acid, or CGP 42'446, is a third generation, nitrogen containing bisphosphonate similar to ibandronic acid, minodronic acid, and risedronic acid. Zoledronic acid is used to treat and prevent multiple forms of osteoporosis, hypercalcemia of malignancy, multiple myeloma, bone metastases from solid tumors, and Paget’s disease of bone. Zoledronic acid ...
- Indication
Zoledronic acid is indicated to treat hypercalcemia of malignancy, multiple myeloma, bone metastases from solid tumors, osteoporosis in men and postmenopausal women, glucocorticoid induced osteoporosis, and Paget's disease of bone in men and women. Zoledronic acid is also indicated for the prevention of osteoporosis in post menopausal women and glucocorticoi...
- Associated Conditions
- Bone Metastases, Hypercalcemia of Malignancy, Multiple Myeloma (MM), Osteoporosis, Osteoporosis caused by Glucocorticoid Treatment, Paget's Disease of Bone, Paget’s Disease
- Associated Therapies
- Bone Mineral Density
Effects of Zometa and Physical Activity on Bone Density in Women Receiving Chemotherapy for Breast Cancer
- Conditions
- First Posted Date
- 2005-09-20
- Last Posted Date
- 2015-12-16
- Lead Sponsor
- HealthPartners Institute
- Target Recruit Count
- 72
- Registration Number
- NCT00202059
- Locations
- 🇺🇸
Park Nicollet Institute, St. Louis Park, Minnesota, United States
RADAR Trial - Randomised Androgen Deprivation and Radiotherapy
- Conditions
- Interventions
- First Posted Date
- 2005-09-19
- Last Posted Date
- 2017-10-12
- Lead Sponsor
- Trans Tasman Radiation Oncology Group
- Target Recruit Count
- 1071
- Registration Number
- NCT00193856
- Locations
- 🇦🇺
Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
🇦🇺Royal North Shore Hospital, Sydney, New South Wales, Australia
🇦🇺St George Hospital, Kogarah, New South Wales, Australia
Zoledronic Acid to Prevent Bone Loss During Androgen Deprivation Therapy for Prostate Cancer
- First Posted Date
- 2005-09-16
- Last Posted Date
- 2013-07-11
- Lead Sponsor
- Massachusetts General Hospital
- Target Recruit Count
- 60
- Registration Number
- NCT00181584
- Locations
- 🇺🇸
Massachusetts General Hospital, Boston, Massachusetts, United States
🇺🇸Dana-Farber Cancer Institute, Boston, Massachusetts, United States
Study to Assess Efficacy and Safety of Zoledronic Acid and the Value of Markers of Bone Resorption in the Prediction of Bone Metastases and Cancer Treatment-induced Bone Loss (CTIBL) in Patients With Prostate Cancer on Hormone Therapy
- First Posted Date
- 2005-09-15
- Last Posted Date
- 2017-03-06
- Lead Sponsor
- Novartis Pharmaceuticals
- Target Recruit Count
- 218
- Registration Number
- NCT00172055
- Locations
- 🇧🇪
Novaris Investigative Site, Libramont, Belgium
🇧🇪Novartis Investigative Site, Woluwe-Saint-Lambert, Belgium
A Study to Evaluate the Efficacy and Tolerability of Zoledronic Acid in Patients With Metastatic Prostate Cancer Who Can be Treated With a Group of Medications Known as Bisphosphonates
- Conditions
- Interventions
- First Posted Date
- 2005-09-15
- Last Posted Date
- 2012-04-30
- Lead Sponsor
- Novartis Pharmaceuticals
- Target Recruit Count
- 43
- Registration Number
- NCT00172016
Zoledronic Acid in the Prevention of Cancer Treatment Related Bone Loss in Postmenopausal Women Receiving Letrozole for Breast Cancer.
- First Posted Date
- 2005-09-15
- Last Posted Date
- 2012-04-16
- Lead Sponsor
- Novartis Pharmaceuticals
- Target Recruit Count
- 1065
- Registration Number
- NCT00171340
- Locations
- 🇻🇪
Novartis Investigative Site, Caracas, Venezuela
🇹🇭Ratchathew, Khonkaen, Thailand
Therapy With Zoledronic Acid in Patients With Multiple Myeloma Stage I
- Conditions
- Interventions
- First Posted Date
- 2005-09-15
- Last Posted Date
- 2012-04-11
- Lead Sponsor
- Novartis Pharmaceuticals
- Target Recruit Count
- 143
- Registration Number
- NCT00171925
- Locations
- 🇩🇪
Novartis Investigative Site, Berlin, Germany
The Use of Zoledronic Acid to Prevent Cancer-treatment Bone Loss in Post-menopausal Women Receiving Adjuvant Letrozole for Breast Cancer
- First Posted Date
- 2005-09-15
- Last Posted Date
- 2012-04-11
- Lead Sponsor
- Novartis Pharmaceuticals
- Target Recruit Count
- 527
- Registration Number
- NCT00171314
- Locations
- 🇪🇸
Novartis Investigative Site, Valencia, Spain
Effect of Zoledronic Acid in Patients With Renal Cell Cancer and Bone Metastasis
- First Posted Date
- 2005-09-15
- Last Posted Date
- 2016-11-18
- Lead Sponsor
- Novartis Pharmaceuticals
- Target Recruit Count
- 50
- Registration Number
- NCT00172003
- Locations
- 🇩🇪
Novartis investigative Site, Offenbach, Germany
A Study to Evaluate the Safety and Efficacy of Zoledronic Acid in the Prevention or Delaying of Bone Metastasis in Patients With Stage IIIA and IIIB Non-small Cell Lung Cancer (NSCLC)
- First Posted Date
- 2005-09-15
- Last Posted Date
- 2015-05-04
- Lead Sponsor
- Novartis Pharmaceuticals
- Target Recruit Count
- 437
- Registration Number
- NCT00172042
- Locations
- 🇬🇧
Novartis Investigative Site, Sutton, United Kingdom
Drug Development Updates
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