MedPath

Ropivacaine

Generic Name
Ropivacaine
Brand Names
Naropin
Drug Type
Small Molecule
Chemical Formula
C17H26N2O
CAS Number
84057-95-4
Unique Ingredient Identifier
7IO5LYA57N
Background

Ropivacaine is an aminoamide local anesthetic drug marketed by AstraZeneca under the trade name Naropin. It exists as a racemate of its S- and R-enantiomers, although the marketed form is supplied only as the purified S-enantiomer.

Indication

Ropivacaine is indicated in adult patients for the induction of regional or local anesthesia for surgery or acute pain management.

Associated Conditions
Acute Pain, Postoperative pain
Associated Therapies
Surgical anesthesia therapy
Clinical Trials
Related News

Local Infiltration With Ropivacaine Improves Postoperative Pain Control in Patients

Not Applicable
Completed
Conditions
Postoperative Pain
Interventions
Drug: Ropivacaine
Drug: 0.9% saline
First Posted Date
2016-01-07
Last Posted Date
2018-07-26
Lead Sponsor
Air Force Military Medical University, China
Target Recruit Count
140
Registration Number
NCT02649179
Locations
🇨🇳

Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China

Spinal Versus Epidural Analgesia in Laparotomic Liver Surgery

Not Applicable
Conditions
Liver Diseases
Liver Neoplasms
Secondary Malignant Neoplasm of Liver
Interventions
Procedure: Spinal analgesia
Procedure: Epidural analgesia
Procedure: Transversus Abdominis Plane block
Procedure: Surgical wound infiltration
Drug: Acetaminophen
Drug: Sufentanil
Drug: Ketorolac
Drug: Ropivacaine
First Posted Date
2016-01-06
Last Posted Date
2016-01-06
Lead Sponsor
Ospedale San Raffaele
Target Recruit Count
40
Registration Number
NCT02647047
Locations
🇮🇹

Ospedale San Raffaele, Milano, MI, Italy

Is PECS Block Equivalent to Paravertebral Block in Preventing Postoperative Pain After Breast Surgery?

Phase 4
Completed
Conditions
Other Acute Postoperative Pain
Interventions
Procedure: Paravertebral block with ropivacaine
Procedure: PECS block with ropivacaine
Drug: Ropivacaine
First Posted Date
2016-01-01
Last Posted Date
2024-08-06
Lead Sponsor
Ospedale Regionale Bellinzona e Valli
Target Recruit Count
23
Registration Number
NCT02645474
Locations
🇨🇭

Ospedale Regionale di Bellinzona e Valli, Bellinzona, Switzerland

Addition of Dexmedetomidine to Ropivacaine-induced Supraclavicular Block (ADRIB Trial)

Phase 4
Completed
Conditions
Ulna Fractures
Hand Injuries
Wrist Injuries
Radius Fractures
Forearm Injuries
Interventions
Drug: Ropivacaine + Dexmedetomidine
Drug: Ropivacaine
First Posted Date
2015-12-15
Last Posted Date
2016-08-12
Lead Sponsor
Guangzhou First People's Hospital
Target Recruit Count
60
Registration Number
NCT02630290
Locations
🇨🇳

Guangzhou First Municipal People's Hospital, Guangzhou, Guangdong, China

Nebulized Analgesia for Laparoscopic Appendectomy Trial

Phase 1
Conditions
Appendicitis
Interventions
Drug: Normal saline
Drug: Ropivacaine
First Posted Date
2015-12-08
Last Posted Date
2016-03-22
Lead Sponsor
McGill University Health Centre/Research Institute of the McGill University Health Centre
Target Recruit Count
200
Registration Number
NCT02624089
Locations
🇨🇦

Montreal Children's Hospital, Montreal, Quebec, Canada

Effects of Dexmedetomidine Used in Continuous Thoracic Paravertebral Blocks

Phase 4
Completed
Conditions
Post-thoracotomy Pain Syndrome
Interventions
Drug: Ropivacaine
Drug: Dexmedetomidine
Device: Mindray M7 series
First Posted Date
2015-12-02
Last Posted Date
2015-12-02
Lead Sponsor
Weifeng Tu
Target Recruit Count
60
Registration Number
NCT02619513
Locations
🇨🇳

Department of Anesthesiology，Guangzhou Military Region General Hospital, Guangzhou, Guangdong, China

Comparing Exparel & Ropivacaine for Pain Relief in Total Knee Arthroplasty

Not Applicable
Conditions
Knee Osteoarthritis
Interventions
Drug: Ropivacaine
Drug: Exparel
First Posted Date
2015-11-18
Last Posted Date
2017-04-27
Lead Sponsor
Monmouth Medical Center
Target Recruit Count
200
Registration Number
NCT02607579
Locations
🇺🇸

Monmouth Medical Center, Long Branch, New Jersey, United States

Exparel Infiltration in Anterior Cruciate Ligament Reconstruction

Phase 4
Completed
Conditions
Pain
Interventions
Procedure: Femoral nerve block
Drug: Liposomal bupivacaine
Drug: Ropivacaine
First Posted Date
2015-11-17
Last Posted Date
2023-12-08
Lead Sponsor
Henry Ford Health System
Target Recruit Count
84
Registration Number
NCT02606448

Adductor Canal Catheter vs Local Infiltration of Analgesia for Total Knee Arthroplasty

Phase 4
Withdrawn
Conditions
Acute Pain
Regional Anesthesia Morbidity
Interventions
Drug: bupivacaine
Drug: ropivacaine
Device: Adductor Canal Catheter
Device: Sham Adductor Canal Catheter
First Posted Date
2015-11-13
Last Posted Date
2021-12-15
Lead Sponsor
Thomas Jefferson University
Registration Number
NCT02603900
Locations
🇺🇸

Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States

Analgesic Efficacy of Transmuscular Quadratus Lumborum in Patients Undergoing Total Abdominal Hysterectomy

Not Applicable
Completed
Conditions
Pain Postoperative
Interventions
Drug: morphine
Procedure: Transmuscular quadratus lumborum block
Drug: ropivacaine
First Posted Date
2015-10-26
Last Posted Date
2017-06-20
Lead Sponsor
Kuala Lumpur General Hospital
Target Recruit Count
64
Registration Number
NCT02586454
Locations
🇲🇾

Hospital Kuala Lumpur, Kuala Lumpur, Malaysia

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