Ropivacaine

Generic Name: Ropivacaine

Brand Names: Naropin

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₂₆N_₂O

CAS Number: 84057-95-4

Unique Ingredient Identifier: 7IO5LYA57N

Background: Ropivacaine is an aminoamide local anesthetic drug marketed by AstraZeneca under the trade name Naropin. It exists as a racemate of its S- and R-enantiomers, although the marketed form is supplied only as the purified S-enantiomer.

Indication: Ropivacaine is indicated in adult patients for the induction of regional or local anesthesia for surgery or acute pain management.

Associated Conditions: Acute Pain, Postoperative pain

Associated Therapies: Surgical anesthesia therapy

Clinical Trials

Application of Combined Lumbar Plexus and Sciatic Nerve Block

Phase 4

Completed

Conditions: Anesthesia

Interventions: Procedure: Nerve block
Procedure: Combined spinal and epidural anesthesia
Drug: Ropivacaine
Drug: Bupivacaine

First Posted Date: 2014-03-12

Last Posted Date: 2014-09-11

Lead Sponsor: Guangzhou General Hospital of Guangzhou Military Command

Target Recruit Count: 34

Registration Number: NCT02084368

Locations: 🇨🇳
Guangzhou Military Region General Hospital, Department of Anesthesiology, Guangzhou, Guangdong, China

Bupivacaine Versus Ropivacaine on Diaphragmatic Motility and Ventilatory Function

Not Applicable

Completed

Conditions: Paresis

Interventions: Drug: Bupivacaine
Drug: Ropivacaine

First Posted Date: 2014-02-11

Last Posted Date: 2014-11-25

Lead Sponsor: Anesthesiology WSU/DMC-NorthStar

Target Recruit Count: 39

Registration Number: NCT02059070

Locations: 🇺🇸
DMC Surgery Hospital, Madison Heights, Michigan, United States

A Comparison of UGSB and GA to IV Narcotics and GA for Post-Op Pain in Children With Supracondylar Fractures.

Phase 4

Terminated

Conditions: Supracondylar Fractures

Interventions: Drug: Ropivacaine
Drug: Fentanyl

First Posted Date: 2014-02-05

Last Posted Date: 2021-05-21

Lead Sponsor: Baylor College of Medicine

Target Recruit Count: 78

Registration Number: NCT02056288

Locations: 🇺🇸
Texas Children't Hospital, Houston, Texas, United States

Analgesia for Positioning Hip Fracture Patients for Spinal Anesthesia

Not Applicable

Completed

Conditions: Hip Fracture

Interventions: Procedure: Fascia iliaca compartment block
Drug: Fentanyl
Drug: ropivacaine

First Posted Date: 2014-01-16

Last Posted Date: 2014-01-16

Lead Sponsor: Asklepieion Voulas General Hospital

Target Recruit Count: 41

Registration Number: NCT02037633

Locations: 🇬🇷
Asklepieion Hospital of Voula, Athens, Attica, Greece

Sole Local Anesthetic Versus Opioid Plus Local Anesthesia in Epidural Labor Analgesia

Phase 4

Completed

Conditions: Pain

Interventions: Drug: Sole local anesthetic
Drug: Sufentanil (Opioid plus local anesthetic)
Drug: Ropivacaine

First Posted Date: 2014-01-14

Last Posted Date: 2014-02-04

Lead Sponsor: Nanjing Medical University

Target Recruit Count: 500

Registration Number: NCT02036242

Locations: 🇨🇳
Nanjing Maternity and Child Health Care Hospital, Nanjing, Jiangsu, China

Adductor Canal Versus Femoral Nerve Block for Analgesia Post Total Knee Arthroscopy

Not Applicable

Conditions: Knee Osteoarthritis

Interventions: Drug: Ropivacaine

First Posted Date: 2014-01-13

Last Posted Date: 2015-01-01

Lead Sponsor: Changi General Hospital

Target Recruit Count: 30

Registration Number: NCT02033603

Locations: 🇸🇬
Changi General Hospital, Singapore, Singapore

Routine Irrigation With Ropivacaine vs. Lidocaine vs. Saline of Surgical Bed in Sleeve Gastrectomy

Not Applicable

Conditions: Overweight and Obesity

Interventions: Drug: control saline
Drug: Ropivacaine
Drug: Lidocaine

First Posted Date: 2013-12-30

Last Posted Date: 2013-12-30

Lead Sponsor: The Baruch Padeh Medical Center, Poriya

Target Recruit Count: 90

Registration Number: NCT02023684

Locations: 🇮🇱
General Surgery Ward, Poriya, The Lower Galilee, Israel

Effect of Mode of Femoral Nerve Analgesia on Quadriceps Muscle Strength

Not Applicable

Conditions: Muscle Weakness

Interventions: Drug: ropivacaine

First Posted Date: 2013-12-11

Last Posted Date: 2014-07-30

Lead Sponsor: Seoul National University Hospital

Target Recruit Count: 36

Registration Number: NCT02007850

Locations: 🇰🇷
Seoul National University Bundang Hospital, Sungnam, Gyungido, Korea, Republic of

Continuous Local Anesthesia Versus Continuous Femoral Nerve Bloc After Total Knee Arthroplasty: Impact on Mean Discharge Aptitude Delay

Phase 4

Terminated

Conditions: Total Knee Arthroplasty

Interventions: Drug: Ropivacaine

First Posted Date: 2013-12-10

Last Posted Date: 2018-08-28

Lead Sponsor: University Hospital, Strasbourg, France

Target Recruit Count: 36

Registration Number: NCT02006355

Locations: 🇫🇷
CCOM-Hôpitaux Universitaires de Strasbourg, Illkirch-Graffenstaden, France

Effects of Epidural Local Anesthetics on Propofol Induction

Phase 4

Completed

Conditions: General Anesthesia
Propofol Target-controlled Infusion
Thoracic Epidural Anesthesia

Interventions: Drug: Normal Saline
Drug: Bupivacaine
Drug: Lidocaine
Drug: Ropivacaine

First Posted Date: 2013-12-04

Last Posted Date: 2014-05-16

Lead Sponsor: First Hospital of China Medical University

Target Recruit Count: 80

Registration Number: NCT02000973

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