Sufentanil

Generic Name: Sufentanil

Brand Names: Dsuvia, Sufenta, Dzuveo

Drug Type: Small Molecule

Chemical Formula: C_₂₂H_₃₀N_₂O_₂S

CAS Number: 56030-54-7

Unique Ingredient Identifier: AFE2YW0IIZ

Background: Sufentanil is an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent. It is administered by the intravenous, epidural and sublingual routes.

Also known as Dsuvia, the sublingual form is used for the management of acute pain in adults that is severe to warrant the use of an opioid analgesic in certified medically supervised healthcare settings, including hospitals, surgical centers, and emergency departments . Consideration may be made in the future for the use of the sublingual form in the US military in cases where analgesia is required immediately .

The sublingual form, manufactured by AcelRx Pharmaceuticals, Inc. (AcelRx), was approved on November 2, 2018 .

This route of administration is intended to be a simple, effective, non-invasive analgesic option to enable healthcare professionals to rapidly manage acute pain without difficult intravenous or epidural administration , .

Indication: The indications for this drug are as follows:

Associated Conditions: Acute Pain, Severe Acute Pain

Associated Therapies: General Anesthesia, Induction and Maintenance of General Anesthesia, Lumbar epidural anesthesia therapy, Short opioid analgesia requirement

Clinical Trials

Spinal Versus Epidural Analgesia in Laparotomic Liver Surgery

Not Applicable

Conditions: Liver Diseases
Liver Neoplasms
Secondary Malignant Neoplasm of Liver

Interventions: Procedure: Spinal analgesia
Procedure: Epidural analgesia
Procedure: Transversus Abdominis Plane block
Procedure: Surgical wound infiltration
Drug: Acetaminophen
Drug: Sufentanil
Drug: Ketorolac
Drug: Ropivacaine

First Posted Date: 2016-01-06

Last Posted Date: 2016-01-06

Lead Sponsor: Ospedale San Raffaele

Target Recruit Count: 40

Registration Number: NCT02647047

Locations: 🇮🇹
Ospedale San Raffaele, Milano, MI, Italy

Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis

Not Applicable

Completed

Conditions: Postoperative Nausea and Vomiting

Interventions: Procedure: Automated recommendation at the start of the case
Procedure: Automated notification at the start of surgery
Procedure: Automated notification at the end of surgery
Device: Anesthesia Information Management System (AIMS)
Device: Perioperative Data Warehouse (PDW)
Procedure: General anesthesia
Procedure: Elective surgery
Drug: Propofol
Drug: Sevoflurane
Drug: Isoflurane
Drug: Desflurane
Drug: Scopolamine
Drug: Droperidol
Drug: Haloperidol
Drug: Dexamethasone
Drug: Promethazine
Drug: Meclizine
Drug: Aprepitant
Drug: Metoclopramide
Drug: Fentanyl
Drug: Sufentanil
Drug: Alfentanil
Drug: Remifentanil
Drug: Morphine
Drug: Meperidine
Drug: Hydromorphone
Drug: Methadone
Drug: Oxycodone
Drug: Oxymorphone
Drug: Hydrocodone
Drug: Ketamine
Drug: Ondansetron
Drug: Granisetron
Drug: Dolasetron mesylate
Drug: Palonosetron
Drug: Tropisetron
Drug: Ramosetron

First Posted Date: 2015-12-09

Last Posted Date: 2019-03-07

Lead Sponsor: Vanderbilt University

Target Recruit Count: 27034

Registration Number: NCT02625181

Locations: 🇺🇸
Vanderbilt University Medical Center, Nashville, Tennessee, United States

Analgesia Effects of Nalbuphine vs Sulfentanil

Not Applicable

Conditions: C.Delivery; Surgery (Previous), Gynecological

Interventions: Drug: Nalbuphine
Drug: Sufentanil
Drug: flurbiprofen axetil
Drug: ramosetron

First Posted Date: 2015-11-13

Last Posted Date: 2015-11-13

Lead Sponsor: Fudan University

Target Recruit Count: 80

Registration Number: NCT02604797

PIEB vs CEI for Labor Analgesia: An MLAC Study

Phase 4

Terminated

Conditions: Pregnancy

Interventions: Drug: Bupivacaine
Drug: Sufentanil

First Posted Date: 2015-10-12

Last Posted Date: 2022-10-18

Lead Sponsor: Stanford University

Target Recruit Count: 31

Registration Number: NCT02573597

Locations: 🇺🇸
Lucile Packard Children's Hospital, Palo Alto, California, United States

Programmed Intermittent Epidural Bolus Versus Continuous Epidural Infusion for Third Trimester Medical Termination of Pregnancy Analgesia : a Randomized Study. (PCEA-IMG)

Phase 3

Completed

Conditions: Anesthesia, Epidural

Interventions: Procedure: Patient Controlled Epidural Analgesia for third trimester termination of preganancy analgesia
Drug: Levobupivacaine
Drug: sufentanil
Drug: clonidine
Device: epidural catheter