Levothyroxine
- Generic Name
- Levothyroxine
- Brand Names
- Eltroxin, Ermeza, Euthyrox, Levo-T, Levothroid, Levoxyl, Np Thyroid, Synthroid, Thyquidity, Tirosint, Unithroid
- Drug Type
- Small Molecule
- Chemical Formula
- C15H11I4NO4
- CAS Number
- 51-48-9
- Unique Ingredient Identifier
- Q51BO43MG4
- Background
Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quantities of the thyroid hormones T (tetraio...
- Indication
Levothyroxine is indicated as replacement therapy in primary (thyroidal), secondary (pituitary) and tertiary (hypothalamic) congenital or acquired hypothyroidism. It is also indicated as an adjunct to surgery and radioiodine therapy in the management of thyrotropin-dependent well-differentiated thyroid cancer.
- Associated Conditions
- Edematous Fibrosclerotic Panniculopathy (Cellulite), Hypothyroidism, Localized Adiposity, Myxedema coma, Euthyroid Goitre, Thyrotropin dependent Well-Differentiated Thyroid Cancer
- Associated Therapies
- -
Intravenous Thyroxine for Heart-Eligible Organ Donors
- First Posted Date
- 2020-06-04
- Last Posted Date
- 2024-01-10
- Lead Sponsor
- Washington University School of Medicine
- Target Recruit Count
- 838
- Registration Number
- NCT04415658
- Locations
- 🇺🇸
Lifesharing, San Diego, California, United States
🇺🇸Texas Organ Sharing Alliance, San Antonio, Texas, United States
🇺🇸Mid-America Transplant Services, Saint Louis, Missouri, United States
The Effect of Thyroid Hormone Therapy on Muscle Mass and Function in Older Adults With Subclinical Hypothyroidism
- Conditions
- Interventions
- First Posted Date
- 2020-04-21
- Last Posted Date
- 2023-05-18
- Lead Sponsor
- Insel Gruppe AG, University Hospital Bern
- Target Recruit Count
- 322
- Registration Number
- NCT04354896
- Locations
- 🇨🇭
Clinic for General Internal Medicine, Bern University Hospital Bern, Bern, Switzerland
🇳🇱Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, Netherlands
🇳🇱Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, Netherlands
Discontinuation of Levothyroxine Therapy for Patients With Subclinical Hypothyroidism
- First Posted Date
- 2020-02-28
- Last Posted Date
- 2023-11-18
- Lead Sponsor
- VA Office of Research and Development
- Target Recruit Count
- 52
- Registration Number
- NCT04288115
- Locations
- 🇺🇸
Central Arkansas Veterans Healthcare System Eugene J. Towbin Healthcare Center, Little Rock, AR, North Little Rock, Arkansas, United States
Can Levothyroxine Treatment Reduce the Development of Cardio-metabolic Disorder in Subclinical Hypothyroidism?
- First Posted Date
- 2019-11-26
- Last Posted Date
- 2019-11-29
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 40
- Registration Number
- NCT04178928
Low Dose Euthyrox in Treatments of Paraquat Intoxication.
- First Posted Date
- 2019-10-21
- Last Posted Date
- 2019-10-22
- Target Recruit Count
- 80
- Registration Number
- NCT04132622
A Study of Armour® Thyroid Compared to Synthetic T4 (Levothyroxine) in Previously Hypothyroid Participants
- Conditions
- Interventions
- First Posted Date
- 2019-10-11
- Last Posted Date
- 2024-06-05
- Lead Sponsor
- Allergan
- Target Recruit Count
- 284
- Registration Number
- NCT04124705
- Locations
- 🇺🇸
Sponsor Site /ID# 235853, Fort Lauderdale, Florida, United States
🇺🇸Sponsor Site /ID# 236809, West Palm Beach, Florida, United States
🇺🇸Sponsor Site /ID# 235032, Atlanta, Georgia, United States
Improving White Matter Integrity With Thyroid Hormone
- First Posted Date
- 2019-09-23
- Last Posted Date
- 2020-04-10
- Lead Sponsor
- University of Illinois at Chicago
- Target Recruit Count
- 5
- Registration Number
- NCT04098991
- Locations
- 🇺🇸
University of Illinois at Chicago, Chicago, Illinois, United States
A Randomized Controlled Trial of Thyroid Hormone Supplementation in Hemodialysis Patients
- Conditions
- Interventions
- First Posted Date
- 2019-06-06
- Last Posted Date
- 2024-02-29
- Lead Sponsor
- University of California, Irvine
- Target Recruit Count
- 336
- Registration Number
- NCT03977207
- Locations
- 🇺🇸
University of California Irvine, Orange, California, United States
Supplementation of Thyroid Hormone for TSH Control in Patients With Chronic Kidney Disease Without TRR.
- Conditions
- Interventions
- First Posted Date
- 2019-04-02
- Last Posted Date
- 2019-04-02
- Lead Sponsor
- Hospital Civil de Guadalajara
- Target Recruit Count
- 32
- Registration Number
- NCT03898622
- Locations
- 🇲🇽
Kidney health clinic, Civil Hospital of Guadalajara, Guadalajara, Jalisco, Mexico
Quality of Life After Interventional Thyroid Treatment
- First Posted Date
- 2019-03-19
- Last Posted Date
- 2024-10-29
- Lead Sponsor
- Klinikum Lüdenscheid
- Target Recruit Count
- 101
- Registration Number
- NCT03880578
- Locations
- 🇩🇪
Department of Nuclear Medicine Klinikum Luedenscheid, Luedenscheid, NRW, Germany
Drug Development Updates
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