Levothyroxine
- Generic Name
- Levothyroxine
- Brand Names
- Eltroxin, Ermeza, Euthyrox, Levo-T, Levothroid, Levoxyl, Np Thyroid, Synthroid, Thyquidity, Tirosint, Unithroid
- Drug Type
- Small Molecule
- Chemical Formula
- C15H11I4NO4
- CAS Number
- 51-48-9
- Unique Ingredient Identifier
- Q51BO43MG4
- Background
Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quantities of the thyroid hormones T (tetraio...
- Indication
Levothyroxine is indicated as replacement therapy in primary (thyroidal), secondary (pituitary) and tertiary (hypothalamic) congenital or acquired hypothyroidism. It is also indicated as an adjunct to surgery and radioiodine therapy in the management of thyrotropin-dependent well-differentiated thyroid cancer.
- Associated Conditions
- Edematous Fibrosclerotic Panniculopathy (Cellulite), Hypothyroidism, Localized Adiposity, Myxedema coma, Euthyroid Goitre, Thyrotropin dependent Well-Differentiated Thyroid Cancer
- Associated Therapies
- -
The TRUST Trial - CardioVascular Imaging ECHO
- Conditions
- Interventions
- First Posted Date
- 2016-07-14
- Last Posted Date
- 2017-02-28
- Lead Sponsor
- Insel Gruppe AG, University Hospital Bern
- Target Recruit Count
- 185
- Registration Number
- NCT02832960
- Locations
- 🇨🇭
Clinic for General Internal Medicine, Bern University Hospital Bern, Bern, Switzerland
🇨🇭Cardiology Division, Geneva University Hospitals, Geneva, Switzerland
🇨🇭Department of General Internal Medicine, Lausanne, Vaud, Switzerland
Mean Percentage of Levothyroxine Dosage Increase in Patients With Hypothyroidism Started on Enteral Feeding
- First Posted Date
- 2015-10-16
- Last Posted Date
- 2021-09-22
- Lead Sponsor
- Jocelyne Karam
- Registration Number
- NCT02577367
- Locations
- 🇺🇸
Maimonides Medical Center, Brooklyn, New York, United States
Levothyroxine Treatment for Subclinical Hypothyroidism After Head and Neck Surgery
- Conditions
- Interventions
- First Posted Date
- 2015-09-14
- Last Posted Date
- 2022-07-13
- Lead Sponsor
- University of Alberta
- Registration Number
- NCT02548715
Thyroid Hormone Replacement for Hypothyroidism and Acute Myocardial Infarction(ThyroHeart-AMI)
- First Posted Date
- 2015-07-31
- Last Posted Date
- 2018-07-16
- Target Recruit Count
- 160
- Registration Number
- NCT02512978
- Locations
- 🇨🇳
Fuwai Cardiovascular Hospital, Beijing, China
The Effect of Administration of Small Doses of Thyroxine on Glucose and Lipid Metabolism, in Type 2 Diabetes Mellitus.
- Conditions
- Interventions
- First Posted Date
- 2015-07-28
- Last Posted Date
- 2015-07-28
- Lead Sponsor
- Attikon Hospital
- Target Recruit Count
- 33
- Registration Number
- NCT02509858
Effect of Thyroid Hormone Replacement on Fatigability in Untreated Older Adults With Subclinical Hypothyroidism
- Conditions
- Interventions
- First Posted Date
- 2015-07-16
- Last Posted Date
- 2019-03-29
- Lead Sponsor
- Insel Gruppe AG, University Hospital Bern
- Target Recruit Count
- 276
- Registration Number
- NCT02500342
- Locations
- 🇮🇪
University College Cork, National University of Ireland, Cork, Ireland
🇨🇭Clinic for General Internal Medicine, Bern University Hospital Bern, Bern, Switzerland
🇨🇭Department of General Internal Medicine, Lausanne, Vaud, Switzerland
Novel Biomarkers and Skeletal Outcomes Associated With Subclinical Thyroid Dysfunction
- Conditions
- Interventions
- First Posted Date
- 2015-07-07
- Last Posted Date
- 2017-02-01
- Lead Sponsor
- Insel Gruppe AG, University Hospital Bern
- Target Recruit Count
- 145
- Registration Number
- NCT02491008
- Locations
- 🇨🇭
Clinic for General Internal Medicine, Bern University Hospital Bern, Bern, Switzerland
🇨🇭Department of General Internal Medicine, Lausanne, Vaud, Switzerland
Effect of Levothyroxine on Serum Adiponectin, Insulin Resistance and Cardiovascular Risk in Patients With Hypothyroidism
- First Posted Date
- 2015-06-10
- Last Posted Date
- 2019-10-01
- Target Recruit Count
- 120
- Registration Number
- NCT02467244
- Locations
- 🇮🇳
AIIMS, Bhubaneswar, Bhubaneshwar, Odisha, India
Mechanistic Study of Subclinical Hypothyroidism In the Elderly
- Conditions
- Interventions
- First Posted Date
- 2015-03-26
- Last Posted Date
- 2021-03-09
- Lead Sponsor
- University of Pennsylvania
- Target Recruit Count
- 14
- Registration Number
- NCT02399475
- Locations
- 🇺🇸
University of Pennsylvania, Philadelphia, Pennsylvania, United States
Targeted Levothyroxine Dosing in Infants With Congenital Hypothyroidism
- Conditions
- Interventions
- First Posted Date
- 2015-03-02
- Last Posted Date
- 2017-10-09
- Lead Sponsor
- Erica Eugster
- Target Recruit Count
- 24
- Registration Number
- NCT02374593
- Locations
- 🇺🇸
Riley Hospital for Children, Indianapolis, Indiana, United States
Drug Development Updates
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