Acetaminophen

Generic Name
Acetaminophen
Brand Names
Acephen, Acetadryl, Allzital, Apadaz, Arthriten Inflammatory Pain, Bupap, Butapap, Cetafen, Children's Silapap, Coricidin Hbp Cold & Flu, Darvocet-N, Dayquil Sinex, Diphen, Dolofin, Dologen, Dologesic Reformulated Jun 2016, Duralgina, Dvorah, Endocet, Esgic, Exaprin, Excedrin, Excedrin PM Triple Action, Excedrin Tension Headache, Feverall, Fioricet, Fioricet With Codeine, Goody's Back & Body Pain Relief, Goody's Body Pain, Goody's Extra Strength, Goody's Headache Relief Shot, Goody's PM, Hycet, Legatrin PM, Little Fevers, Lorcet, Lortab, Mapap, Mersyndol, Midol Complete, Midol Cramps & Bodyaches, Nalocet, Norco, Orbivan, Pamprin Max Formula, Pamprin Multi-symptom, Panadol, Pediacare Children's Fever Reducer Pain Reliever, Percocet, Percogesic Reformulated Jan 2011, Pharbetol, Premsyn Pms, Prolate, Rivacocet, Robaxacet, Robaxacet-8, Roxicet, Sudafed PE Sinus Headache, Tactinal, Tencon, Trezix, Triatec, Triatec-30, Triatec-8, Tylenol, Tylenol PM, Tylenol With Codeine, Ultracet, Vanatol, Vanatol S, Vanquish, Xodol, Xolox, Zamicet, Zflex, Zydone
Drug Type
Small Molecule
Chemical Formula
C8H9NO2
CAS Number
103-90-2
Unique Ingredient Identifier
362O9ITL9D
Background

Acetaminophen (paracetamol), also commonly known as Tylenol, is the most commonly taken analgesic worldwide and is recommended as first-line therapy in pain conditions by the World Health Organization (WHO). It is also used for its antipyretic effects, helping to reduce fever. This drug was initially approved by the U.S. FDA in 1951 and is available in a variety of forms including syrup form, regular tablets, effervescent tablets, injection, suppository, and other forms.

Acetaminophen is often found combined with other drugs in more than 600 over the counter (OTC) allergy medications, cold medications, sleep medications, pain relievers, and other products. Confusion about dosing of this drug may be caused by the availability of different formulas, strengths, and dosage instructions for children of different ages. Due to the possibility of fatal overdose and liver failure associated with the incorrect use of acetaminophen, it is important to follow current and available national and manufacturer dosing guidelines while this drug is taken or prescribed.

Indication

In general, acetaminophen is used for the treatment of mild to moderate pain and reduction of fever. It is available over the counter in various forms, the most common being oral forms.

Acetaminophen injection is indicated for the management of mild to moderate pain, the management of moderate to severe pain with adjunctive opioid analgesics, and the reduction of fever.

Because of its low risk of causing allergic reactions, this drug can be administered in patients who are intolerant to salicylates and those with allergic tendencies, including bronchial asthmatics. Specific dosing guidelines should be followed when administering acetaminophen to children.

Associated Conditions
Acute Gouty Arthritis, Acute Musculoskeletal Pain, Allergic Reaction, Allergy to Tree Pollen, Ankylosing Spondylitis (AS), Chills, Cold, Common Cold, Cough, Cough caused by Common Cold, Coughing caused by Flu caused by Influenza, Dyskinesia of the Biliary Tract, Dyskinesia of the Urinary Tract, Febrile Convulsions, Febrile Illness Acute, Fever, Fibromyalgia, Flu caused by Influenza, Headache, Joint dislocations, Menstrual Distress (Dysmenorrhea), Mild pain, Muscle Inflammation, Muscle Injuries, Muscle Spasms, Musculoskeletal Pain, Myalgia, Nasal Congestion, Neuropathic Pain, Osteoarthritis (OA), Pain, Postoperative pain, Premenstrual cramps, Rheumatoid Arthritis, Rhinopharyngitis, Rhinorrhoea, Severe Pain, Sinusitis, Spasms, Spastic Pain of the Gastrointestinal Tract, Sprains, Symptoms Cold, Tension Headache, Toothache, Upper Respiratory Tract Infection, Whiplash Syndrome, Acute Torticollis, Articular inflammation, Cold or flu syndrome, Mild to moderate pain, Minor aches and pains, Minor pain, Moderate Pain, Moderate to severe pain
Associated Therapies
Airway secretion clearance therapy, Anti-spasmodics, Bronchodilation

Pre-emptive Analgesics in Orthodontic Treatment

Phase 4
Completed
Conditions
Interventions
First Posted Date
2018-05-14
Last Posted Date
2019-08-21
Lead Sponsor
University of Washington
Target Recruit Count
73
Registration Number
NCT03523988
Locations
🇺🇸

University of Washington, Seattle, Washington, United States

Multimodal Analgesia Versus Traditional Opiate Based Analgesia

First Posted Date
2018-05-11
Last Posted Date
2018-05-11
Lead Sponsor
Shanghai Zhongshan Hospital
Target Recruit Count
225
Registration Number
NCT03521167

Multimodal Analgesia With Acetaminophen vs. Narcotics Alone After Hip Arthroscopy

Phase 4
Completed
Conditions
Interventions
First Posted Date
2018-04-27
Last Posted Date
2021-01-07
Lead Sponsor
NYU Langone Health
Target Recruit Count
100
Registration Number
NCT03510910
Locations
🇺🇸

New York University School of Medicine, New York, New York, United States

Intravenous Tramadol Versus Intravenous Paracetamol in Patients With Dysmenorrhea

Phase 4
Completed
Conditions
Interventions
First Posted Date
2018-04-26
Last Posted Date
2020-06-16
Lead Sponsor
Cairo University
Target Recruit Count
100
Registration Number
NCT03509740
Locations
🇪🇬

Aljazeerah Hospital, Giza, Egypt

Does Gabapentin Reduce Quadriceps Muscle Weakness After Anterior Cruciate Ligament Reconstruction?

First Posted Date
2018-04-12
Last Posted Date
2018-04-12
Lead Sponsor
Hospital Authority, Hong Kong
Target Recruit Count
30
Registration Number
NCT03496389

Adjuncts to IVRA, a Comparison Between Ketorolac and Paracetamol

First Posted Date
2018-04-02
Last Posted Date
2020-07-24
Lead Sponsor
Assiut University
Target Recruit Count
60
Registration Number
NCT03485625
Locations
🇪🇬

Omar Ali, Assiut, Egypt

Consequences of Doing What Should Not be Done in Primary Care

First Posted Date
2018-03-29
Last Posted Date
2020-04-03
Lead Sponsor
Universidad Miguel Hernandez de Elche
Target Recruit Count
750000
Registration Number
NCT03482232
Locations
🇪🇸

FISABIO, Elche, Alicante, Spain

🇪🇸

Universidad Miguel Hernández, Elche, Alicante, Spain

Tramadol vs.Tramadol With Paracetamol

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2018-03-29
Last Posted Date
2018-03-29
Lead Sponsor
Yeditepe University Hospital
Target Recruit Count
60
Registration Number
NCT03482492

A Cohort Study Evaluating the Efficacy of PO Magnesium in the Treatment of Acute Traumatic Brain Injury in Adolescents

First Posted Date
2018-03-23
Last Posted Date
2024-11-28
Lead Sponsor
Spectrum Health - Lakeland
Target Recruit Count
17
Registration Number
NCT03475693
Locations
🇺🇸

Lakeland Regional Healthcare, Saint Joseph, Michigan, United States

A Comparative Efficacy Trial of IV Acetaminophen Versus IV Ketorolac for Emergency Department Treatment of Generalized Headache

Phase 4
Withdrawn
Conditions
Interventions
First Posted Date
2018-03-21
Last Posted Date
2024-11-29
Lead Sponsor
Spectrum Health - Lakeland
Registration Number
NCT03472872
Locations
🇺🇸

Lakeland Regional Healthcare, Saint Joseph, Michigan, United States

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