Acetaminophen (paracetamol), also commonly known as Tylenol, is the most commonly taken analgesic worldwide and is recommended as first-line therapy in pain conditions by the World Health Organization (WHO). It is also used for its antipyretic effects, helping to reduce fever. This drug was initially approved by the U.S. FDA in 1951 and is available in a variety of forms including syrup form, regular tablets, effervescent tablets, injection, suppository, and other forms.
Acetaminophen is often found combined with other drugs in more than 600 over the counter (OTC) allergy medications, cold medications, sleep medications, pain relievers, and other products. Confusion about dosing of this drug may be caused by the availability of different formulas, strengths, and dosage instructions for children of different ages. Due to the possibility of fatal overdose and liver failure associated with the incorrect use of acetaminophen, it is important to follow current and available national and manufacturer dosing guidelines while this drug is taken or prescribed.
In general, acetaminophen is used for the treatment of mild to moderate pain and reduction of fever. It is available over the counter in various forms, the most common being oral forms.
Acetaminophen injection is indicated for the management of mild to moderate pain, the management of moderate to severe pain with adjunctive opioid analgesics, and the reduction of fever.
Because of its low risk of causing allergic reactions, this drug can be administered in patients who are intolerant to salicylates and those with allergic tendencies, including bronchial asthmatics. Specific dosing guidelines should be followed when administering acetaminophen to children.
Premier Research, Austin, Texas, United States
Clinical Solutions Ltd., Auckland, New Zealand
Clinical Trial New Zealand, Hamilton, Waikato, New Zealand
Department of Occupational and Physiotherapy, Aalborg University Hospital, Aalborg, Denmark
Vendsyssel Hospital, Frederikshavn, Frederikshavn, Denmark
Farsoe Hospital, Farsø, Denmark
King Abdulaziz Medical City, Riyadh, Central, Saudi Arabia
National Institutes of Health Clinical Center, Bethesda, Maryland, United States
NZOZ Praktyka Lekarza Rodzinnego Eskulap, Lublin, Poland
NZOZ Nasz Lekarz, Torun, Poland
DEN-MED Gabinet Lekarsko-Stomatologiczny Joanna i Jacek Witwiccy, Warszawa, Poland
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