Acetaminophen (paracetamol), also commonly known as Tylenol, is the most commonly taken analgesic worldwide and is recommended as first-line therapy in pain conditions by the World Health Organization (WHO). It is also used for its antipyretic effects, helping to reduce fever. This drug was initially approved by the U.S. FDA in 1951 and is available in a variety of forms including syrup form, regular tablets, effervescent tablets, injection, suppository, and other forms.
Acetaminophen is often found combined with other drugs in more than 600 over the counter (OTC) allergy medications, cold medications, sleep medications, pain relievers, and other products. Confusion about dosing of this drug may be caused by the availability of different formulas, strengths, and dosage instructions for children of different ages. Due to the possibility of fatal overdose and liver failure associated with the incorrect use of acetaminophen, it is important to follow current and available national and manufacturer dosing guidelines while this drug is taken or prescribed.
In general, acetaminophen is used for the treatment of mild to moderate pain and reduction of fever. It is available over the counter in various forms, the most common being oral forms.
Acetaminophen injection is indicated for the management of mild to moderate pain, the management of moderate to severe pain with adjunctive opioid analgesics, and the reduction of fever.
Because of its low risk of causing allergic reactions, this drug can be administered in patients who are intolerant to salicylates and those with allergic tendencies, including bronchial asthmatics. Specific dosing guidelines should be followed when administering acetaminophen to children.
Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia
St George Hospital, Sydney, New South Wales, Australia
Pfizer Investigational Site, Salt Lake City, Utah, United States
Clinical Research Facility, Royal Infirmary of Edinburgh, Edinburgh, Midlothian, United Kingdom
Barzilai medical center, Ashkelon, Israel
Vanderbilt University Medical Center, Nashville, Tennessee, United States
CHU Clermont-Ferrand, Clermont-Ferrand, France
Jean Brown Research, Salt Lake City, Utah, United States
Hospital Del Mar, Barcelona, Spain
Therapeutic Research Unit, Department of Internal Medicine, Hospital Lariboière, Paris, France
University of Colorado Health Sciences Center, Aurora, Colorado, United States
University of Minnesota Health Clinics and Surgery Center, Minneapolis, Minnesota, United States
Boston University Medical Center, Boston, Massachusetts, United States
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