Acetaminophen

Generic Name: Acetaminophen

Brand Names: Acephen, Acetadryl, Allzital, Apadaz, Arthriten Inflammatory Pain, Bupap, Butapap, Cetafen, Children's Silapap, Coricidin Hbp Cold & Flu, Darvocet-N, Dayquil Sinex, Diphen, Dolofin, Dologen, Dologesic Reformulated Jun 2016, Duralgina, Dvorah, Endocet, Esgic, Exaprin, Excedrin, Excedrin PM Triple Action, Excedrin Tension Headache, Feverall, Fioricet, Fioricet With Codeine, Goody's Back & Body Pain Relief, Goody's Body Pain, Goody's Extra Strength, Goody's Headache Relief Shot, Goody's PM, Hycet, Legatrin PM, Little Fevers, Lorcet, Lortab, Mapap, Mersyndol, Midol Complete, Midol Cramps & Bodyaches, Nalocet, Norco, Orbivan, Pamprin Max Formula, Pamprin Multi-symptom, Panadol, Pediacare Children's Fever Reducer Pain Reliever, Percocet, Percogesic Reformulated Jan 2011, Pharbetol, Premsyn Pms, Prolate, Rivacocet, Robaxacet, Robaxacet-8, Roxicet, Sudafed PE Sinus Headache, Tactinal, Tencon, Trezix, Triatec, Triatec-30, Triatec-8, Tylenol, Tylenol PM, Tylenol With Codeine, Ultracet, Vanatol, Vanatol S, Vanquish, Xodol, Xolox, Zamicet, Zflex, Zydone

Drug Type: Small Molecule

Chemical Formula: C_₈H_₉NO_₂

CAS Number: 103-90-2

Unique Ingredient Identifier: 362O9ITL9D

Background: Acetaminophen (paracetamol), also commonly known as Tylenol, is the most commonly taken analgesic worldwide and is recommended as first-line therapy in pain conditions by the World Health Organization (WHO). It is also used for its antipyretic effects, helping to reduce fever. This drug was initially approved by the U.S. FDA in 1951 and is available in a var...

Indication: In general, acetaminophen is used for the treatment of mild to moderate pain and reduction of fever. It is available over the counter in various forms, the most common being oral forms.
...

Associated Conditions: Acute Gouty Arthritis, Acute Musculoskeletal Pain, Allergic Reaction, Allergy to Tree Pollen, Ankylosing Spondylitis (AS), Chills, Cold, Common Cold, Cough, Cough caused by Common Cold, Coughing caused by Flu caused by Influenza, Dyskinesia of the Biliary Tract, Dyskinesia of the Urinary Tract, Febrile Convulsions, Febrile Illness Acute, Fever, Fibromyalgia, Flu caused by Influenza, Headache, Joint dislocations, Menstrual Distress (Dysmenorrhea), Mild pain, Muscle Inflammation, Muscle Injuries, Muscle Spasms, Musculoskeletal Pain, Myalgia, Nasal Congestion, Neuropathic Pain, Osteoarthritis (OA), Pain, Postoperative pain, Premenstrual cramps, Rheumatoid Arthritis, Rhinopharyngitis, Rhinorrhoea, Severe Pain, Sinusitis, Spasms, Spastic Pain of the Gastrointestinal Tract, Sprains, Symptoms Cold, Tension Headache, Toothache, Upper Respiratory Tract Infection, Whiplash Syndrome, Acute Torticollis, Articular inflammation, Cold or flu syndrome, Mild to moderate pain, Minor aches and pains, Minor pain, Moderate Pain, Moderate to severe pain

Associated Therapies: Airway secretion clearance therapy, Anti-spasmodics, Bronchodilation

Clinical Trials

Controlled-Release Oxycodone For Postoperative Analgesia After Video-Assisted Thoracic Surgery

Phase 4

Terminated

Conditions: Anesthesia Recovery Period
Pain, Postoperative

Interventions: Drug: Morphine
Drug: oxycodone
Procedure: Paravertebral block
Drug: Propofol
Drug: Remifentanil
Drug: Paracetamol

First Posted Date: 2008-05-21

Last Posted Date: 2012-01-06

Lead Sponsor: University of Parma

Target Recruit Count: 22

Registration Number: NCT00681174

Locations: 🇮🇹
University Hospital / Azienda Ospedaliero-Universitaria, Parma, PR, Italy

Effect of Combined Use of Naloxone and Tramacet on Postop Analgesia in Elderly Patients Having Joint Replacement Surgery

Phase 3

Completed

Conditions: Hip Arthroplasty
Knee Arthroplasty
Spinal Anesthesia

Interventions: Drug: tramacet, naloxone
Drug: tramacet
Drug: Acetaminophen

First Posted Date: 2008-05-19

Last Posted Date: 2017-08-28

Lead Sponsor: Lawson Health Research Institute

Target Recruit Count: 45

Registration Number: NCT00679614

Locations: 🇨🇦
St Joseph's Health Care, London, Ontario, Canada

Bioavailability Study of Tramadol/APAP Tablets Under Fed Conditions

Phase 1

Completed

Conditions: To Determine Bioequivalence Under Fed Conditions

Interventions: Drug: Tramadol/ APAP
Drug: Ultracet

First Posted Date: 2008-04-04

Last Posted Date: 2017-09-26

Lead Sponsor: Par Pharmaceutical, Inc.

Target Recruit Count: 22

Registration Number: NCT00652821

Bioavailability Study of Tramadol/APAP Tablets Under Fasting Conditions

Phase 1

Completed

Conditions: To Determine Bioequivalence Under Fasting Conditions

Interventions: Drug: Tramadol APAP
Drug: Ultracet

First Posted Date: 2008-04-04

Last Posted Date: 2008-04-11

Lead Sponsor: Par Pharmaceutical, Inc.

Target Recruit Count: 28

Registration Number: NCT00653315

Tramadol/Acetaminophen(Ultracet) AS add-on Therapy in the Treatment of Patients With Ankylosing Spondylitis

Phase 4

Completed

Conditions: Ankylosing Spondylitis

Interventions: Drug: Ultracet

First Posted Date: 2008-03-31

Last Posted Date: 2010-04-01

Lead Sponsor: Chung Shan Medical University

Target Recruit Count: 60

Registration Number: NCT00647517

Locations: 🇨🇳
Chung Shan Medical University Hospital, Taichung, Taiwan

Interaction Between Antihypertensives and Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

Phase 4

Completed

Conditions: Hypertension

Interventions: Drug: acetaminophen
Drug: ibuprofen
Drug: piroxicam

First Posted Date: 2008-03-07

Last Posted Date: 2008-03-10

Lead Sponsor: University Hospital of Split

Target Recruit Count: 88

Registration Number: NCT00631514

Locations: 🇭🇷
Split University School of Medicine. Family Practice Department, Split, Croatia

Oral Glycerol and High-Dose Rectal Paracetamol to Improve the Prognosis of Childhood Bacterial Meningitis

Phase 3

Completed

Conditions: Bacterial Meningitis

Interventions: Drug: Placebo
Drug: Glycerol and paracetamol
Drug: Paracetamol
Drug: Paracetamol and glycerol
Drug: Glycerol

First Posted Date: 2008-02-20

Last Posted Date: 2012-07-10

Lead Sponsor: Kamuzu University of Health Sciences

Target Recruit Count: 466

Registration Number: NCT00619203

Locations: 🇲🇼
College of Medicine, Queen Elizabeth Central Hospital, Blantyre, Malawi

Acetaminophen Adduct Formation in Non-Drinkers Taking Therapeutic Doses of Acetaminophen for Ten Consecutive Days

Phase 4

Completed

Conditions: Drug Induced Liver Injury

Interventions: Drug: acetaminophen

First Posted Date: 2008-02-14

Last Posted Date: 2012-07-12

Lead Sponsor: Kennon Heard

Target Recruit Count: 35

Registration Number: NCT00616018

Locations: 🇺🇸
Denver Health Rocky Mountain Poison and Drug Center, Denver, Colorado, United States

A Four-Week Study Comparing Acetaminophen Extended Release and Rofecoxib in the Treatment of Osteoarthritis of the Knee

Phase 3

Completed

Conditions: Osteoarthritis of the Knee

Interventions: Drug: acetaminophen
Drug: Rofecoxib

First Posted Date: 2007-12-06

Last Posted Date: 2011-08-22

Lead Sponsor: Johnson & Johnson Consumer and Personal Products Worldwide

Target Recruit Count: 403

Registration Number: NCT00568295

Effects of Acetaminophen on Hurt Feelings

Not Applicable

Completed

Conditions: Emotional Pain

Interventions: Drug: acetaminophen
Other: cornstarch

First Posted Date: 2007-11-20

Last Posted Date: 2008-06-25

Lead Sponsor: University of Toronto

Target Recruit Count: 60

Registration Number: NCT00561288

Locations: 🇨🇦
University of Toronto, Toronto, Ontario, Canada

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