Acetaminophen

Generic Name: Acetaminophen

Brand Names: Acephen, Acetadryl, Allzital, Apadaz, Arthriten Inflammatory Pain, Bupap, Butapap, Cetafen, Children's Silapap, Coricidin Hbp Cold & Flu, Darvocet-N, Dayquil Sinex, Diphen, Dolofin, Dologen, Dologesic Reformulated Jun 2016, Duralgina, Dvorah, Endocet, Esgic, Exaprin, Excedrin, Excedrin PM Triple Action, Excedrin Tension Headache, Feverall, Fioricet, Fioricet With Codeine, Goody's Back & Body Pain Relief, Goody's Body Pain, Goody's Extra Strength, Goody's Headache Relief Shot, Goody's PM, Hycet, Legatrin PM, Little Fevers, Lorcet, Lortab, Mapap, Mersyndol, Midol Complete, Midol Cramps & Bodyaches, Nalocet, Norco, Orbivan, Pamprin Max Formula, Pamprin Multi-symptom, Panadol, Pediacare Children's Fever Reducer Pain Reliever, Percocet, Percogesic Reformulated Jan 2011, Pharbetol, Premsyn Pms, Prolate, Rivacocet, Robaxacet, Robaxacet-8, Roxicet, Sudafed PE Sinus Headache, Tactinal, Tencon, Trezix, Triatec, Triatec-30, Triatec-8, Tylenol, Tylenol PM, Tylenol With Codeine, Ultracet, Vanatol, Vanatol S, Vanquish, Xodol, Xolox, Zamicet, Zflex, Zydone

Drug Type: Small Molecule

Chemical Formula: C_₈H_₉NO_₂

CAS Number: 103-90-2

Unique Ingredient Identifier: 362O9ITL9D

Background: Acetaminophen (paracetamol), also commonly known as Tylenol, is the most commonly taken analgesic worldwide and is recommended as first-line therapy in pain conditions by the World Health Organization (WHO). It is also used for its antipyretic effects, helping to reduce fever. This drug was initially approved by the U.S. FDA in 1951 and is available in a var...

Indication: In general, acetaminophen is used for the treatment of mild to moderate pain and reduction of fever. It is available over the counter in various forms, the most common being oral forms.
...

Associated Conditions: Acute Gouty Arthritis, Acute Musculoskeletal Pain, Allergic Reaction, Allergy to Tree Pollen, Ankylosing Spondylitis (AS), Chills, Cold, Common Cold, Cough, Cough caused by Common Cold, Coughing caused by Flu caused by Influenza, Dyskinesia of the Biliary Tract, Dyskinesia of the Urinary Tract, Febrile Convulsions, Febrile Illness Acute, Fever, Fibromyalgia, Flu caused by Influenza, Headache, Joint dislocations, Menstrual Distress (Dysmenorrhea), Mild pain, Muscle Inflammation, Muscle Injuries, Muscle Spasms, Musculoskeletal Pain, Myalgia, Nasal Congestion, Neuropathic Pain, Osteoarthritis (OA), Pain, Postoperative pain, Premenstrual cramps, Rheumatoid Arthritis, Rhinopharyngitis, Rhinorrhoea, Severe Pain, Sinusitis, Spasms, Spastic Pain of the Gastrointestinal Tract, Sprains, Symptoms Cold, Tension Headache, Toothache, Upper Respiratory Tract Infection, Whiplash Syndrome, Acute Torticollis, Articular inflammation, Cold or flu syndrome, Mild to moderate pain, Minor aches and pains, Minor pain, Moderate Pain, Moderate to severe pain

Associated Therapies: Airway secretion clearance therapy, Anti-spasmodics, Bronchodilation

Clinical Trials

Acetaminophen Before Vaccines for Infants Study (AVIS)

Phase 3

Completed

Conditions: Fever

Interventions: Other: placebo
Drug: Acetaminophen

First Posted Date: 2006-05-15

Last Posted Date: 2017-10-13

Lead Sponsor: Kaiser Permanente

Target Recruit Count: 374

Registration Number: NCT00325819

Locations: 🇺🇸
Group Health Research Institute, Seattle, Washington, United States

Tailoring Treatment for B Cell Non-hodgkin's Lymphoma Based on PET Scan Results Mid Treatment

Phase 2

Conditions: Lymphoma, Non-Hodgkin
Advanced Stage Diffuse Large B-Cell Non-Hodgkin's Lymphoma

Interventions: Drug: Cyclophosphamide
Drug: Doxorubicin
Drug: Vincristine
Drug: Prednisone
Drug: Ondansetron
Drug: Dexamethasone
Drug: Diphenhydramine
Drug: Acetaminophen
Other: PET Scan
Drug: Ifosfamide
Drug: Mesna (IV)
Drug: Mesna (oral)
Drug: Carboplatin
Drug: Etoposide
Drug: Rituximab

First Posted Date: 2006-05-11

Last Posted Date: 2021-07-22

Lead Sponsor: British Columbia Cancer Agency

Target Recruit Count: 150

Registration Number: NCT00324467

Locations: 🇨🇦
BC Cancer Agency, Vancouver, British Columbia, Canada

Comparing Intravenous and Oral Paracetamol for Cholecystectomy

Phase 4

Completed

Conditions: Laparoscopic Cholecystectomy

First Posted Date: 2006-02-15

Last Posted Date: 2007-03-09

Lead Sponsor: Melbourne Health

Target Recruit Count: 30

Registration Number: NCT00292214

Locations: 🇦🇺
Royal Melbourne Hospital, Melbourne, Victoria, Australia

A Study to Evaluate the Efficacy and Safety of Rituximab in Subjects With International Society of Nephrology/Renal Pathology Society (ISN/RPS) 2003 Class III or IV Lupus Nephritis

Phase 3

Completed

Conditions: Lupus Nephritis

Interventions: Drug: Placebo
Drug: Rituximab
Drug: Mycophenolate mofetil
Drug: Methylprednisolone
Drug: Diphenhydramine
Drug: Acetaminophen
Drug: Prednisone

First Posted Date: 2006-01-26

Last Posted Date: 2015-01-15

Lead Sponsor: Genentech, Inc.

Target Recruit Count: 144

Registration Number: NCT00282347

Ibuprofen Alone and in Combination With Acetaminophen for Treatment of Fever

Phase 4

Completed

Conditions: Fever

Interventions: Drug: Acetaminophen
Drug: Ibuprofen

First Posted Date: 2005-12-20

Last Posted Date: 2012-05-09

Lead Sponsor: Penn State University

Target Recruit Count: 60

Registration Number: NCT00267293

Locations: 🇺🇸
Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States

A Safety and Effectiveness Study of Acetaminophen Extended Release (3900 mg/Day) and Ibuprofen (1200 mg/Day) in the Treatment of Pain Associated With Ankle Sprains.

Phase 4

Completed

Conditions: Sprains and Strains
Pain

First Posted Date: 2005-12-05

Last Posted Date: 2011-06-29

Lead Sponsor: Johnson & Johnson Consumer and Personal Products Worldwide

Target Recruit Count: 260

Registration Number: NCT00261560

A Safety and Effectiveness Study of Acetaminophen (4000 mg/Day) and Naproxen (750 mg/Day) in the Treatment of Osteoarthritis of the Hip or Knee

Phase 3

Completed

Conditions: Osteoarthritis, Hip
Osteoarthritis, Knee

Interventions: Drug: naproxen
Drug: acetaminophen

First Posted Date: 2005-10-18

Last Posted Date: 2015-06-19

Lead Sponsor: Johnson & Johnson Consumer and Personal Products Worldwide

Target Recruit Count: 581

Registration Number: NCT00240773

An Effectiveness and Safety Study of Acetaminophen 1000 mg and Ibuprofen 400 mg in Postoperative Dental Pain.

Phase 4

Completed

Conditions: Pain

Interventions: Drug: Acetaminophen
Drug: Ibuprofen
Drug: Placebo

First Posted Date: 2005-10-18

Last Posted Date: 2015-06-19

Lead Sponsor: Johnson & Johnson Consumer and Personal Products Worldwide

Target Recruit Count: 222

Registration Number: NCT00240825

An Effectiveness and Safety Study of Acetaminophen 1000 mg and Ibuprofen 400 mg in Postoperative Dental Pain

Phase 4

Completed

Conditions: Pain

Interventions: Drug: placebo
Drug: acetaminophen
Drug: ibuprofen

First Posted Date: 2005-10-18

Last Posted Date: 2015-06-19

Lead Sponsor: Johnson & Johnson Consumer and Personal Products Worldwide

Target Recruit Count: 224

Registration Number: NCT00240864

Postoperative Pain After Medical Abortion Under Local Anesthesia : Comparison of Several Analgesic Regimen

Not Applicable

Completed

Conditions: Abortion, Induced

First Posted Date: 2005-09-16

Last Posted Date: 2017-11-01

Lead Sponsor: University Hospital, Angers

Target Recruit Count: 240

Registration Number: NCT00188071

Locations: 🇫🇷
Dept of Anesthesia - CHU, Angers, France

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