Duloxetine
- Generic Name
- Duloxetine
- Brand Names
- Cymbalta, Drizalma, Irenka, Yentreve, Duloxetine Zentiva, Duloxetine Mylan, Duloxetine Lilly
- Drug Type
- Small Molecule
- Chemical Formula
- C18H19NOS
- CAS Number
- 116539-59-4
- Unique Ingredient Identifier
- O5TNM5N07U
- Background
Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor. It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. It has since received approval for a variety of indications including the tre...
- Indication
Indicated for:
1) Management of Major Depressive Disorder.
2) Management of Generalized Anxiety Disorder.
3) Management of diabetic peripheral neuropathy.
4) Management of fibromyalgia.
5) Management of chronic musculoskeletal pain.
6) Management of osteoarthritis of the knee in adults.
7) Management of chronic lower back pain in adults.
...
- Associated Conditions
- Chronic Lower Back Pain (CLBP), Chronic Musculoskeletal Pain, Diabetic Peripheral Neuropathic Pain (DPN), Fibromyalgia, Generalized Anxiety Disorder, Major Depressive Disorder (MDD), Osteoarthritis of the Knee, Stress Urinary Incontinence (SUI)
- Associated Therapies
- -
Research Examining Gulf War Illness in Our Nations Service Members
- Conditions
- Interventions
- First Posted Date
- 2013-05-03
- Last Posted Date
- 2021-03-12
- Lead Sponsor
- VA Office of Research and Development
- Target Recruit Count
- 112
- Registration Number
- NCT01846182
- Locations
- 🇺🇸
Central Texas Veterans Health Care System Waco VA Medical Center, Waco, TX, Waco, Texas, United States
🇺🇸Central Texas Veterans Health Care System, Temple, TX, Temple, Texas, United States
Algorithm Guided Treatment Strategies for Major Depressive Disorder
- Conditions
- Interventions
- First Posted Date
- 2013-01-10
- Last Posted Date
- 2013-01-10
- Lead Sponsor
- Shanghai Mental Health Center
- Target Recruit Count
- 1080
- Registration Number
- NCT01764867
- Locations
- 🇨🇳
Shanghai Mental Health Center, Shanghai, China
Open Trial of Duloxetine in Outpatients With Irritable Bowel Syndrome Symptoms and Co-Morbid Major Depression
- First Posted Date
- 2012-12-21
- Last Posted Date
- 2021-05-19
- Lead Sponsor
- New York State Psychiatric Institute
- Target Recruit Count
- 17
- Registration Number
- NCT01754493
- Locations
- 🇺🇸
New York State Psychiatric Institute, 1051 Riverside Drive, New York, New York, United States
Mechanisms of Neuromuscular Fatigue Post Stroke
- Conditions
- Interventions
- First Posted Date
- 2012-09-20
- Last Posted Date
- 2015-11-05
- Lead Sponsor
- Medical College of Wisconsin
- Target Recruit Count
- 27
- Registration Number
- NCT01688570
- Locations
- 🇺🇸
Medical College of Wisconsin, Milwaukee, Wisconsin, United States
Study of Placebo Without Deception Versus Standard Antidepressant for Major Depressive Disorder
- Conditions
- Interventions
- First Posted Date
- 2012-07-26
- Last Posted Date
- 2014-12-23
- Lead Sponsor
- Sunnybrook Health Sciences Centre
- Target Recruit Count
- 1
- Registration Number
- NCT01650740
- Locations
- 🇨🇦
Sunnybook Health Sciences Centre, Toronto, Ontario, Canada
An Extension Study of Duloxetine in Fibromyalgia (Extension of F1J-JE-HMGZ, NCT01552057)
- First Posted Date
- 2012-06-18
- Last Posted Date
- 2015-02-11
- Lead Sponsor
- Eli Lilly and Company
- Target Recruit Count
- 149
- Registration Number
- NCT01621191
- Locations
- 🇯🇵
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., Miyagi, Japan
Cymbalta for Fibromyalgia Pain - Predictive Value of Small Fiber Changed
- First Posted Date
- 2012-06-14
- Last Posted Date
- 2019-08-09
- Lead Sponsor
- University of California, San Diego
- Registration Number
- NCT01619566
- Locations
- 🇺🇸
University of California, San Diego Medical Centers, San Diego, California, United States
A Study Comparing the Efficacy and Safety of ABT-652 to Placebo in Subjects With Diabetic Neuropathic Pain
- Conditions
- Interventions
- First Posted Date
- 2012-04-17
- Last Posted Date
- 2013-09-26
- Lead Sponsor
- AbbVie (prior sponsor, Abbott)
- Target Recruit Count
- 1
- Registration Number
- NCT01579279
- Locations
- 🇺🇸
Site Reference ID/Investigator# 63710, Milford, Connecticut, United States
🇺🇸Site Reference ID/Investigator# 62887, Anaheim, California, United States
🇺🇸Site Reference ID/Investigator# 62884, DeLand, Florida, United States
Efficacy of Lu AA21004 on Cognitive Dysfunction in Major Depressive Disorder
- Conditions
- Interventions
- First Posted Date
- 2012-03-28
- Last Posted Date
- 2015-02-05
- Lead Sponsor
- Takeda
- Target Recruit Count
- 602
- Registration Number
- NCT01564862
Duloxetine in Osteoarthritis (OA) Pain
- First Posted Date
- 2012-03-20
- Last Posted Date
- 2014-12-29
- Lead Sponsor
- Northwestern University
- Target Recruit Count
- 40
- Registration Number
- NCT01558700
- Locations
- 🇺🇸
Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States
Drug Development Updates
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