MedPath

Mitoquinone

Generic Name
Mitoquinone
Drug Type
Small Molecule
Chemical Formula
C37H44O4P
CAS Number
444890-41-9
Unique Ingredient Identifier
47BYS17IY0

Overview

Mitoquinone is based on a novel technology, targeted lipophilic cations, that transport and concentrate antioxidants into the mitochondria -- organelles inside cells that provide energy for life processes -- where they accumulate up to a thousand fold. In 2004, a genomic study of hereditary early-onset Parkinson's disease demonstrated a direct molecular link between mitochondrial dysfunction and the pathogenesis of Parkinson's disease. Mitochondrial dysfunction also has been shown to represent an early critical event in the pathogenesis of the sporadic form of Parkinson's disease. Clinical studies by the Parkinson's Study Group show that very high doses of an antioxidant called Coenzyme Q (which Mitoquinone effectively targets into mitochondria) appear to slow the progression of Parkinson's disease symptoms.

Indication

Investigated for use/treatment in hepatitis (viral, C) and parkinson's disease.

Associated Conditions

No associated conditions information available.

Clinical Trials

Title
Posted
Study ID
Phase
Status
Sponsor
2024/05/24
Phase 2
Active, not recruiting
2024/01/05
Phase 2
Recruiting
2023/09/07
Phase 2
Recruiting
UConn Health
2022/11/04
Early Phase 1
Terminated
2021/12/07
Not Applicable
UNKNOWN
D'Or Institute for Research and Education
2017/05/25
Phase 1
Terminated
2015/11/04
Not Applicable
Completed
2010/07/22
Phase 2
Terminated
2007/02/09
Phase 2
Completed
2006/05/24
Phase 2
Completed

FDA Drug Approvals

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No FDA approvals found for this drug.

EMA Drug Approvals

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No EMA approvals found for this drug.

HSA Drug Approvals

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No HSA approvals found for this drug.

NMPA Drug Approvals

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No NMPA approvals found for this drug.

PPB Drug Approvals

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Strength
Registration Date
No PPB approvals found for this drug.

TGA Drug Approvals

Approved Product
ARTG ID
Sponsor
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Status
Registration Date
No TGA approvals found for this drug.

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