Colchicine
- Generic Name
- Colchicine
- Brand Names
- Colcrys, Gloperba, Lodoco, Mitigare
- Drug Type
- Small Molecule
- Chemical Formula
- C22H25NO6
- CAS Number
- 64-86-8
- Unique Ingredient Identifier
- SML2Y3J35T
- Background
Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as Colchicum autumnale, or "autumn crocus." Its use was first approved by the FDA in 1961. Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events. It has also been investigated in other inflammato...
- Indication
Colchicine is indicated for the prophylaxis and treatment of gout flares. It is also indicated in Familial Mediterranean fever (FMF) in children and adults of four years of age and older. It is also indicated to reduce the risk of myocardial infarction (MI), stroke, coronary revascularization, and cardiovascular death in adult patients with established ather...
- Associated Conditions
- Behcet's Syndrome, Cardiovascular Mortality, Coronary Revascularization, Familial Mediterranean Fever (FMF ), Gout Flares, Myocardial Infarction, Pericarditis, Postpericardiotomy Syndrome, Stroke
- Associated Therapies
- -
Post-Ablation Pericarditis Reduction Study (PAPERS)
- Conditions
- Interventions
- First Posted Date
- 2024-12-12
- Last Posted Date
- 2024-12-12
- Lead Sponsor
- St. Vincent Cardiovascular Research Institute
- Target Recruit Count
- 248
- Registration Number
- NCT06731595
- Locations
- 🇺🇸
Ascension St Vincent Hospital, Indianapolis, Indiana, United States
The Effect of ColcHicine on the Incidence of Knee or Hip Replacements
- Conditions
- Interventions
- First Posted Date
- 2024-08-29
- Last Posted Date
- 2024-12-04
- Lead Sponsor
- Sint Maartenskliniek
- Target Recruit Count
- 1200
- Registration Number
- NCT06578182
Colchicine Versus Beta-blockers, Angiotensin-converting Enzyme Inhibitors, and Statins for Prevention of Chemotherapy-Induced Cardiomyopathy
- Conditions
- Interventions
- First Posted Date
- 2024-03-12
- Last Posted Date
- 2024-03-12
- Lead Sponsor
- Arab Contractors Medical Centre
- Target Recruit Count
- 150
- Registration Number
- NCT06304896
- Locations
- 🇪🇬
Arab Contractors Medical Centre, Cairo, Egypt
Aggressive Risk-Prevention Therapies for Coronary Atherosclerotic Plaque (ART-CAP)
- Conditions
- Interventions
- First Posted Date
- 2024-02-28
- Last Posted Date
- 2024-04-25
- Lead Sponsor
- University of Louisville
- Target Recruit Count
- 200
- Registration Number
- NCT06280976
- Locations
- 🇺🇸
University of Louisville School of Medicine, Division of Cardiovascular Diseases, Louisville, Kentucky, United States
Colchicine in Patients at Cardiac Risk Undergoing Major Non-Cardiac Surgery
- Conditions
- Interventions
- First Posted Date
- 2024-02-26
- Last Posted Date
- 2024-02-28
- Lead Sponsor
- Cantonal Hospital of St. Gallen
- Target Recruit Count
- 880
- Registration Number
- NCT06279000
- Locations
- 🇨🇭
Cantonal Hospital St. Gallen, St. Gallen, Saint Gallen, Switzerland
Reversing Microvascular Dysfunction in Heart Failure With Preserved Ejection Fraction
- Conditions
- Interventions
- First Posted Date
- 2024-01-22
- Last Posted Date
- 2024-01-25
- Lead Sponsor
- Montreal Heart Institute
- Target Recruit Count
- 60
- Registration Number
- NCT06217120
- Locations
- 🇨🇦
Montreal Heart Institute, Montréal, Quebec, Canada
A Mechanistic Clinical Trial of Colchicine in Patients Undergoing Femoral Endarterectomy
- Conditions
- Interventions
- First Posted Date
- 2024-01-18
- Last Posted Date
- 2024-10-02
- Lead Sponsor
- University of Pennsylvania
- Target Recruit Count
- 24
- Registration Number
- NCT06212271
- Locations
- 🇺🇸
University of Pennsylvania, Philadelphia, Pennsylvania, United States
Inflammation REduction to Prevent cArdiovascular Injury in Renal Disease (REPAIR)
- Conditions
- Interventions
- First Posted Date
- 2024-01-12
- Last Posted Date
- 2024-03-28
- Lead Sponsor
- Hamilton Health Sciences Corporation
- Target Recruit Count
- 200
- Registration Number
- NCT06203977
- Locations
- 🇨🇦
Hamilton Health Sciences Corporation, Hamilton, Ontario, Canada
CMP-MYTHiC Trial and Registry - CardioMyoPathy With MYocarditis THerapy With Colchicine
- Conditions
- Interventions
- First Posted Date
- 2023-12-06
- Last Posted Date
- 2024-12-13
- Lead Sponsor
- Niguarda Hospital
- Target Recruit Count
- 80
- Registration Number
- NCT06158698
- Locations
- 🇮🇹
Policlinico S.Orsola-Malpighi, Bologna, Emilia Romagna, Italy
🇮🇹Università degli studi della Campania L.Vanvitelli e Azienda Ospedaliera Specialistica dei Colli - Ospedale Monaldi, Napoli, Campania, Italy
🇮🇹Azienda Sanitaria Universitaria Integrata Giuliano Isontina, Trieste, Trieste, Friuli-Venezia Giulia, Italy
Withdrawal of Colchicine in Behçet Syndrome
- First Posted Date
- 2023-11-24
- Last Posted Date
- 2023-11-24
- Lead Sponsor
- Istanbul University - Cerrahpasa (IUC)
- Target Recruit Count
- 130
- Registration Number
- NCT06146192
Drug Development Updates
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