Colchicine
- Generic Name
- Colchicine
- Brand Names
- Colcrys, Gloperba, Lodoco, Mitigare
- Drug Type
- Small Molecule
- Chemical Formula
- C22H25NO6
- CAS Number
- 64-86-8
- Unique Ingredient Identifier
- SML2Y3J35T
- Background
Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as Colchicum autumnale, or "autumn crocus." Its use was first approved by the FDA in 1961. Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events. It has also been investigated in other inflammatory and fibrotic conditions.
- Indication
Colchicine is indicated for the prophylaxis and treatment of gout flares. It is also indicated in Familial Mediterranean fever (FMF) in children and adults of four years of age and older. It is also indicated to reduce the risk of myocardial infarction (MI), stroke, coronary revascularization, and cardiovascular death in adult patients with established atherosclerotic disease or with multiple risk factors for cardiovascular disease.
Some off-label uses of colchicine include the treatment of the manifestations of Behcet's syndrome, pericarditis, and postpericardiotomy syndrome.
- Associated Conditions
- Behcet's Syndrome, Cardiovascular Mortality, Coronary Revascularization, Familial Mediterranean Fever (FMF ), Gout Flares, Myocardial Infarction, Pericarditis, Postpericardiotomy Syndrome, Stroke
Study of Colchicine to Prevent the Postpericardiotomy Syndrome
- Conditions
- Postpericardiotomy Syndrome
- First Posted Date
- 2005-08-10
- Last Posted Date
- 2010-06-15
- Lead Sponsor
- Azienda Sanitaria Locale 3, Torino
- Target Recruit Count
- 360
- Registration Number
- NCT00128427
- Locations
- 🇮🇹
Ospedale Niguarda, Milano, Italy
🇮🇹Ospedali Riuniti, Bergamo, Italy
🇮🇹Ospedale Regionale Bolzano, Bolzano, Italy
Study of Colchicine to Treat and Prevent Recurrent Pericarditis (First Episode)
- Conditions
- PericarditisRecurrence
- Interventions
- Drug: Placebo
- First Posted Date
- 2005-08-10
- Last Posted Date
- 2011-02-16
- Lead Sponsor
- Azienda Sanitaria Locale 3, Torino
- Target Recruit Count
- 120
- Registration Number
- NCT00128414
- Locations
- 🇮🇹
Internal Medicine Dpt. Ospedali Riuniti, Bergamo, Italy
🇮🇹Ospedale di Rivoli, Rivoli, Italy
🇮🇹Cardiology Dpt. Ospedale SS Annunziata, Savigliano, CN, Italy
Low-Dose Oral Methotrexate Versus Colchicine for Primary Biliary Cirrhosis
- Conditions
- Liver Cirrhosis, Biliary
- First Posted Date
- 2000-02-25
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- National Center for Research Resources (NCRR)
- Target Recruit Count
- 90
- Registration Number
- NCT00004748
Asthma Clinical Research Network (ACRN)
- Conditions
- Lung DiseasesAsthma
- First Posted Date
- 1999-10-28
- Last Posted Date
- 2017-01-16
- Lead Sponsor
- Milton S. Hershey Medical Center
- Registration Number
- NCT00000577
- Locations
- 🇺🇸
Brigham and Women's Hospital, Boston, Massachusetts, United States
🇺🇸University of California, San Francisco, San Francisco, California, United States
🇺🇸University of California at San Diego, La Jolla, California, United States
Phase I Study of Colchicine Therapy in Childhood Hepatic Cirrhosis
- Conditions
- CirrhosisLiver Cirrhosis
- First Posted Date
- 1999-10-19
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- National Center for Research Resources (NCRR)
- Target Recruit Count
- 15
- Registration Number
- NCT00004368
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.