Colchicine
- Generic Name
- Colchicine
- Brand Names
- Colcrys, Gloperba, Lodoco, Mitigare
- Drug Type
- Small Molecule
- Chemical Formula
- C22H25NO6
- CAS Number
- 64-86-8
- Unique Ingredient Identifier
- SML2Y3J35T
- Background
Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as Colchicum autumnale, or "autumn crocus." Its use was first approved by the FDA in 1961. Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events. It has also been investigated in other inflammatory and fibrotic conditions.
- Indication
Colchicine is indicated for the prophylaxis and treatment of gout flares. It is also indicated in Familial Mediterranean fever (FMF) in children and adults of four years of age and older. It is also indicated to reduce the risk of myocardial infarction (MI), stroke, coronary revascularization, and cardiovascular death in adult patients with established atherosclerotic disease or with multiple risk factors for cardiovascular disease.
Some off-label uses of colchicine include the treatment of the manifestations of Behcet's syndrome, pericarditis, and postpericardiotomy syndrome.
- Associated Conditions
- Behcet's Syndrome, Cardiovascular Mortality, Coronary Revascularization, Familial Mediterranean Fever (FMF ), Gout Flares, Myocardial Infarction, Pericarditis, Postpericardiotomy Syndrome, Stroke
Drug-Drug Interaction Study of Colchicine and Theophylline
- First Posted Date
- 2009-09-24
- Last Posted Date
- 2010-03-02
- Lead Sponsor
- Mutual Pharmaceutical Company, Inc.
- Target Recruit Count
- 30
- Registration Number
- NCT00983905
- Locations
- 🇺🇸
PRACS Institute, Ltd. - Cetero Research, Fargo, North Dakota, United States
Drug-Drug Interaction Study Between Colchicine and Ketoconazole
- First Posted Date
- 2009-09-24
- Last Posted Date
- 2009-10-15
- Lead Sponsor
- Mutual Pharmaceutical Company, Inc.
- Target Recruit Count
- 24
- Registration Number
- NCT00983216
- Locations
- 🇺🇸
PRACS Institute, Ltd. - Cetero Research, Fargo, North Dakota, United States
A Drug-Food Interaction Study Between Colchicine and Grapefruit Juice
- First Posted Date
- 2009-09-24
- Last Posted Date
- 2011-11-21
- Lead Sponsor
- Mutual Pharmaceutical Company, Inc.
- Target Recruit Count
- 24
- Registration Number
- NCT00984009
- Locations
- 🇺🇸
PRACS Institute, Ltd. - Cetero Research, Fargo, North Dakota, United States
Drug-Drug Interaction Study of Colchicine and Azithromycin
- First Posted Date
- 2009-09-24
- Last Posted Date
- 2009-10-28
- Lead Sponsor
- Mutual Pharmaceutical Company, Inc.
- Target Recruit Count
- 24
- Registration Number
- NCT00983294
Drug-Drug Interaction Between Colchicine and Ritonavir
- First Posted Date
- 2009-09-24
- Last Posted Date
- 2009-10-15
- Lead Sponsor
- Mutual Pharmaceutical Company, Inc.
- Target Recruit Count
- 24
- Registration Number
- NCT00983515
- Locations
- 🇺🇸
PRACS Institute, Ltd. - Cetero Research, East Grand Forks, Minnesota, United States
Drug-Drug Interaction Between Colchicine and Verapamil ER
- First Posted Date
- 2009-09-24
- Last Posted Date
- 2009-10-15
- Lead Sponsor
- Mutual Pharmaceutical Company, Inc.
- Target Recruit Count
- 24
- Registration Number
- NCT00983242
- Locations
- 🇺🇸
PRACS Institute, Ltd. - Cetero Research, East Grand Forks, Minnesota, United States
Drug-Drug Interaction Study of Colchicine and Clarithromycin
- First Posted Date
- 2009-09-24
- Last Posted Date
- 2009-10-15
- Lead Sponsor
- Mutual Pharmaceutical Company, Inc.
- Target Recruit Count
- 24
- Registration Number
- NCT00984061
- Locations
- 🇺🇸
PRACS Institute, Ltd. - Cetero Research, Fargo, North Dakota, United States
Drug-Drug Interaction Study Between Colchicine and Diltiazem ER
- Conditions
- Healthy; Adult; Volunteer; Colchicine; Pharmacokinetics; Diltiazem; Cytochrome p450 3A4; P-glycoprotein
- Interventions
- First Posted Date
- 2009-09-24
- Last Posted Date
- 2009-10-15
- Lead Sponsor
- Mutual Pharmaceutical Company, Inc.
- Target Recruit Count
- 24
- Registration Number
- NCT00983372
- Locations
- 🇺🇸
PRACS Institute, Ltd. - Cetero Research, Fargo, North Dakota, United States
Colchicine Treatment for Chronic Shoulder Pain Related to Calcific Tendonitis
- First Posted Date
- 2009-09-23
- Last Posted Date
- 2010-07-20
- Lead Sponsor
- Bnai Zion Medical Center
- Target Recruit Count
- 80
- Registration Number
- NCT00983177
- Locations
- 🇮🇱
Bnai Zion Medical Center, Haifa, Israel
Drug-Drug Interaction Study Between Colchicine and Atorvastatin
- First Posted Date
- 2009-08-17
- Last Posted Date
- 2010-03-30
- Lead Sponsor
- Mutual Pharmaceutical Company, Inc.
- Target Recruit Count
- 24
- Registration Number
- NCT00960323
- Locations
- 🇺🇸
PRACS Institute, Ltd. - Cetero Research, Fargo, North Dakota, United States
Drug Development Updates
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