Colchicine
- Generic Name
- Colchicine
- Brand Names
- Colcrys, Gloperba, Lodoco, Mitigare
- Drug Type
- Small Molecule
- Chemical Formula
- C22H25NO6
- CAS Number
- 64-86-8
- Unique Ingredient Identifier
- SML2Y3J35T
- Background
Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as Colchicum autumnale, or "autumn crocus." Its use was first approved by the FDA in 1961. Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events. It has also been investigated in other inflammatory and fibrotic conditions.
- Indication
Colchicine is indicated for the prophylaxis and treatment of gout flares. It is also indicated in Familial Mediterranean fever (FMF) in children and adults of four years of age and older. It is also indicated to reduce the risk of myocardial infarction (MI), stroke, coronary revascularization, and cardiovascular death in adult patients with established atherosclerotic disease or with multiple risk factors for cardiovascular disease.
Some off-label uses of colchicine include the treatment of the manifestations of Behcet's syndrome, pericarditis, and postpericardiotomy syndrome.
- Associated Conditions
- Behcet's Syndrome, Cardiovascular Mortality, Coronary Revascularization, Familial Mediterranean Fever (FMF ), Gout Flares, Myocardial Infarction, Pericarditis, Postpericardiotomy Syndrome, Stroke
Drug-Food Interaction Study of Seville Orange Juice and Colchicine
- First Posted Date
- 2009-08-17
- Last Posted Date
- 2011-06-08
- Lead Sponsor
- Mutual Pharmaceutical Company, Inc.
- Target Recruit Count
- 24
- Registration Number
- NCT00960193
- Locations
- 🇺🇸
PRACS Institute, Ltd. - Cetero Research, Fargo, North Dakota, United States
Efficacy of Long-term Ribavirin in Non-responders With Chronic Hepatitis C and Advanced Fibrosis
- First Posted Date
- 2009-02-10
- Last Posted Date
- 2013-01-31
- Lead Sponsor
- Hospital Universitario Ramon y Cajal
- Target Recruit Count
- 50
- Registration Number
- NCT00840489
- Locations
- 🇪🇸
Hospital Universitario Ramon y Cajal, Madrid, Spain
🇪🇸Hospital General Universitario Gregorio Marañón, Madrid, Spain
🇪🇸Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain
A Study of the Efficacy of Canakinumab in Prevention of Acute Flares in Chronic Gout Patients Initiating Allopurinol Therapy (Core Study) and a Long-term Study of the Efficacy and Safety of Canakinumab in Patients With Gout (Extension Study)
- Conditions
- Gout
- Interventions
- First Posted Date
- 2009-01-09
- Last Posted Date
- 2018-07-17
- Lead Sponsor
- Novartis Pharmaceuticals
- Target Recruit Count
- 432
- Registration Number
- NCT00819585
- Locations
- 🇺🇸
Talbert Medical Group, Huntington Beach, California, United States
🇺🇸Health Awareness, Jupiter, Florida, United States
🇺🇸East-West Medical Research institute, Honolulu, Hawaii, United States
Targeting Inflammation in Acute Coronary Syndrome Using Colchicine
- First Posted Date
- 2008-09-18
- Last Posted Date
- 2009-10-08
- Lead Sponsor
- Hamilton Health Sciences Corporation
- Target Recruit Count
- 80
- Registration Number
- NCT00754819
- Locations
- 🇨🇦
Hamilton General Hospital, Hamilton, Ontario, Canada
Evaluation of Therapeutic Effect of 0.5 mg Colchicine and 5 mg Prednisolone on Oral Aphthae
- First Posted Date
- 2008-07-28
- Last Posted Date
- 2008-07-29
- Lead Sponsor
- Mashhad University of Medical Sciences
- Target Recruit Count
- 30
- Registration Number
- NCT00723268
- Locations
- 🇮🇷
Mashhad Dental school, Mashhad, Khorasan Razavi, Iran, Islamic Republic of
Colchicine Randomized Double-Blind Controlled Crossover Study in Behcet's Disease
- First Posted Date
- 2008-06-18
- Last Posted Date
- 2008-06-18
- Lead Sponsor
- Tehran University of Medical Sciences
- Target Recruit Count
- 169
- Registration Number
- NCT00700297
- Locations
- 🇮🇷
Rheumatology research Center, Tehran UMS, Tehran, Iran, Islamic Republic of
Efficacy of Oral Colchicine in Prevention of Proliferative Vitreoretinopathy in Rhegmatogenous Retinal Detachment
- Conditions
- Rhegmatogenous Retinal Detachment
- First Posted Date
- 2006-08-31
- Last Posted Date
- 2006-10-09
- Lead Sponsor
- Shahid Beheshti University of Medical Sciences
- Registration Number
- NCT00370201
- Locations
- 🇮🇷
Hamid Ahmadieh,MD, Tehran, Iran, Islamic Republic of
Study of Colchicine to Treat and Prevent Recurrent Pericarditis After Failure of Conventional Treatment.
- First Posted Date
- 2005-10-10
- Last Posted Date
- 2013-08-07
- Lead Sponsor
- Azienda Sanitaria Locale 3, Torino
- Target Recruit Count
- 240
- Registration Number
- NCT00235079
- Locations
- 🇮🇹
Cardiology Department. Maria Vittoria Hospital ASL3 Torino (Coordinating Center), Torino, Italy
🇮🇹Ospedale Regionale, Bolzano, Italy
🇮🇹Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy
Study of Long-term Peg Intron vs. Colchicine in Non-responders.
- Conditions
- Hepatitis C VirusAdvanced FibrosisCirrhosis
- Interventions
- First Posted Date
- 2005-09-16
- Last Posted Date
- 2017-07-11
- Lead Sponsor
- Beth Israel Deaconess Medical Center
- Target Recruit Count
- 549
- Registration Number
- NCT00179413
- Locations
- 🇺🇸
Southern Clinical Research Consultants, Hollywood, Florida, United States
🇺🇸Lahey Clinic, Burlington, Massachusetts, United States
🇺🇸Fallon Clinic, Worcester, Massachusetts, United States
Study of Colchicine to Treat Acute Pericarditis and Prevent Recurrences
- First Posted Date
- 2005-08-10
- Last Posted Date
- 2012-06-07
- Lead Sponsor
- Azienda Sanitaria Locale 3, Torino
- Target Recruit Count
- 240
- Registration Number
- NCT00128453
- Locations
- 🇮🇹
Internal Medicine Division, Bergamo, Italy
🇮🇹Cardiology Department-Ospedale Regionale, Bolzano, Italy
🇮🇹Ospedale di Rivoli, Rivoli, Italy
Drug Development Updates
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