Colchicine
- Generic Name
- Colchicine
- Brand Names
- Colcrys, Gloperba, Lodoco, Mitigare
- Drug Type
- Small Molecule
- Chemical Formula
- C22H25NO6
- CAS Number
- 64-86-8
- Unique Ingredient Identifier
- SML2Y3J35T
- Background
Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as Colchicum autumnale, or "autumn crocus." Its use was first approved by the FDA in 1961. Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events. It has also been investigated in other inflammatory and fibrotic conditions.
- Indication
Colchicine is indicated for the prophylaxis and treatment of gout flares. It is also indicated in Familial Mediterranean fever (FMF) in children and adults of four years of age and older. It is also indicated to reduce the risk of myocardial infarction (MI), stroke, coronary revascularization, and cardiovascular death in adult patients with established atherosclerotic disease or with multiple risk factors for cardiovascular disease.
Some off-label uses of colchicine include the treatment of the manifestations of Behcet's syndrome, pericarditis, and postpericardiotomy syndrome.
- Associated Conditions
- Behcet's Syndrome, Cardiovascular Mortality, Coronary Revascularization, Familial Mediterranean Fever (FMF ), Gout Flares, Myocardial Infarction, Pericarditis, Postpericardiotomy Syndrome, Stroke
Drug Interaction Study of Colchicine and Theophylline
- First Posted Date
- 2012-05-17
- Last Posted Date
- 2013-06-17
- Lead Sponsor
- Takeda
- Target Recruit Count
- 30
- Registration Number
- NCT01601132
- Locations
- 🇺🇸
Worlwide Clinical Trials Drug Development Solutions, Clinical Research Services, San Antonio, Texas, United States
COlchicine for Prevention of the Post-pericardiotomy Syndrome and Post-operative Atrial Fibrillation (COPPS-2 Trial)
- Conditions
- Cardiac SurgeryPost-pericardiotomy SyndromeAtrial FibrillationPericardial EffusionPleural Effusion
- Interventions
- Drug: Placebo
- First Posted Date
- 2012-03-13
- Last Posted Date
- 2014-07-01
- Lead Sponsor
- Maria Vittoria Hospital
- Target Recruit Count
- 360
- Registration Number
- NCT01552187
- Locations
- 🇮🇹
Cardiology Dpt. Maria Vittoria Hospital, Torino, Italy
Oral Colchicine in Men With Castrate Resistant Prostate Cancer
- First Posted Date
- 2011-11-29
- Last Posted Date
- 2013-09-27
- Lead Sponsor
- Milton S. Hershey Medical Center
- Registration Number
- NCT01481233
Efficacy and Safety of Colchicine for the Prevention of Gout Flares During the Initiation of Allopurinol
- Conditions
- Intercritical Gout
- Interventions
- First Posted Date
- 2011-10-14
- Last Posted Date
- 2014-05-12
- Lead Sponsor
- Regeneron Pharmaceuticals
- Target Recruit Count
- 82
- Registration Number
- NCT01451645
Open Label Safety/Efficacy Study of Arhalofenate in Combination With Febuxostat for Hyperuricemia in Gout Patients
- Conditions
- HyperuricemiaGout
- Interventions
- First Posted Date
- 2011-08-15
- Last Posted Date
- 2015-04-03
- Lead Sponsor
- CymaBay Therapeutics, Inc.
- Target Recruit Count
- 27
- Registration Number
- NCT01416402
Safety/Efficacy Study to Evaluate of MBX-102 in Combination With Allopurinol in Gout Patients
- Conditions
- Gout
- Interventions
- First Posted Date
- 2011-07-21
- Last Posted Date
- 2015-09-18
- Lead Sponsor
- CymaBay Therapeutics, Inc.
- Target Recruit Count
- 100
- Registration Number
- NCT01399008
Safety and Efficacy Study of MBX-102 in Treatment of Hyperuricemia in Patients With Gout
- Conditions
- HyperuricemiaGout
- Interventions
- First Posted Date
- 2011-04-18
- Last Posted Date
- 2015-04-17
- Lead Sponsor
- CymaBay Therapeutics, Inc.
- Target Recruit Count
- 67
- Registration Number
- NCT01336686
A Pilot Study for PK/PD Parameter of Colchicine in Chronic Kidney Disease Patient.
- First Posted Date
- 2010-07-30
- Last Posted Date
- 2010-12-29
- Lead Sponsor
- Seoul National University Hospital
- Target Recruit Count
- 80
- Registration Number
- NCT01173107
- Locations
- 🇰🇷
Seoul National University Hospital, Seoul, Korea, Republic of
Bioavailability Study of Colcrys® Crushed and Sprinkled on Applesauce
- First Posted Date
- 2010-05-25
- Last Posted Date
- 2011-05-12
- Lead Sponsor
- Mutual Pharmaceutical Company, Inc.
- Target Recruit Count
- 16
- Registration Number
- NCT01130051
- Locations
- 🇺🇸
Novum Pharmaceutical Research Services, Las Vegas, Nevada, United States
Bioavailability Study of Colcrys® in Apple Juice
- First Posted Date
- 2010-05-14
- Last Posted Date
- 2011-05-03
- Lead Sponsor
- Mutual Pharmaceutical Company, Inc.
- Target Recruit Count
- 16
- Registration Number
- NCT01123395
- Locations
- 🇺🇸
Novum Pharmaceutical Research Services, Las Vegas, Nevada, United States
Drug Development Updates
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