Colchicine
- Generic Name
- Colchicine
- Brand Names
- Colcrys, Gloperba, Lodoco, Mitigare
- Drug Type
- Small Molecule
- Chemical Formula
- C22H25NO6
- CAS Number
- 64-86-8
- Unique Ingredient Identifier
- SML2Y3J35T
- Background
Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as Colchicum autumnale, or "autumn crocus." Its use was first approved by the FDA in 1961. Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events. It has also been investigated in other inflammatory and fibrotic conditions.
- Indication
Colchicine is indicated for the prophylaxis and treatment of gout flares. It is also indicated in Familial Mediterranean fever (FMF) in children and adults of four years of age and older. It is also indicated to reduce the risk of myocardial infarction (MI), stroke, coronary revascularization, and cardiovascular death in adult patients with established atherosclerotic disease or with multiple risk factors for cardiovascular disease.
Some off-label uses of colchicine include the treatment of the manifestations of Behcet's syndrome, pericarditis, and postpericardiotomy syndrome.
- Associated Conditions
- Behcet's Syndrome, Cardiovascular Mortality, Coronary Revascularization, Familial Mediterranean Fever (FMF ), Gout Flares, Myocardial Infarction, Pericarditis, Postpericardiotomy Syndrome, Stroke
COLchicine On-admission to Reduce Inflammation in Acute Coronary Syndrome (COLOR-ACS)
- Conditions
- Non ST Segment Elevation Acute Coronary Syndrome
- Interventions
- First Posted Date
- 2022-02-22
- Last Posted Date
- 2024-07-16
- Lead Sponsor
- Azienda USL Toscana Centro
- Target Recruit Count
- 182
- Registration Number
- NCT05250596
- Locations
- 🇮🇹
Gaia Chiara Selvaggia Magnaghi, Pescia, Italy
🇮🇹Marco Comeglio, Pistoia, Italy
🇮🇹Anna Toso, Prato, Italy
Effect of Combined Use of Ivermectin and Colchicine in COVID-19 Patients
- First Posted Date
- 2022-02-18
- Last Posted Date
- 2022-04-07
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 135
- Registration Number
- NCT05246072
- Locations
- 🇪🇬
Ain Shams University hospitals, Cairo, Egypt
Effect of Colchicine On Left Ventricle Function After Anterior Myocardial Infarction Assessed By Speckle Tracking
- First Posted Date
- 2022-01-20
- Last Posted Date
- 2022-08-23
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 100
- Registration Number
- NCT05200052
- Locations
- 🇪🇬
Ain Shams University hospitals, Cairo, Egypt
Colchicine Use for Primary Prevention of Coronary Artery Disease
- Conditions
- Coronary Artery Disease
- Interventions
- Drug: Placebo
- First Posted Date
- 2022-01-03
- Last Posted Date
- 2022-03-21
- Lead Sponsor
- Qingdao Central Hospital
- Target Recruit Count
- 6792
- Registration Number
- NCT05175274
- Locations
- 🇨🇳
Mengmei Li, Qingdao, Shandong, China
Efficacy and Safety of Low-Dose Colchicine on Surrogate Markers of Cardiovascular Events in People Living With HIV Receiving Antiretroviral Therapy
- Conditions
- HIV InfectionsInflammatory MarkersColchicine Adverse Reaction
- Interventions
- Drug: Placebo
- First Posted Date
- 2021-12-23
- Last Posted Date
- 2021-12-23
- Lead Sponsor
- Mahidol University
- Target Recruit Count
- 84
- Registration Number
- NCT05168137
- Locations
- 🇹🇭
Angsana Phuphuakrat, Ratchathewi, ฺBangkok, Thailand
Colchicine and Inflammation in Aortic Stenosis
- Conditions
- Aortic Valve StenosisCardiovascular DiseasesAortic Valve DiseaseInflammationAortic Valve CalcificationCalcification
- Interventions
- Drug: Placebo
- First Posted Date
- 2021-12-17
- Last Posted Date
- 2025-03-06
- Lead Sponsor
- Radboud University Medical Center
- Target Recruit Count
- 150
- Registration Number
- NCT05162742
- Locations
- 🇳🇱
Radboudumc, Nijmegen, The Netherlands, Netherlands
Colchicine for the Prevention of Vascular Events After an Acute Intracerebral Hemorrhage
- First Posted Date
- 2021-12-16
- Last Posted Date
- 2025-01-16
- Lead Sponsor
- Population Health Research Institute
- Target Recruit Count
- 100
- Registration Number
- NCT05159219
- Locations
- 🇨🇦
Hamilton General Hospital, Hamilton Health Sciences, Hamilton, Ontario, Canada
🇨🇦Kingston General Hospital, Kingston Health Sciences, Kingston, Ontario, Canada
🇨🇦London Health Science Centre, University Hospital, London, Ontario, Canada
Adjuvant Use Of Colchicine With The Standard Therapy In Moderate And Severe Corona Virus Disease-19 Infection
- First Posted Date
- 2021-12-09
- Last Posted Date
- 2021-12-09
- Lead Sponsor
- University of Baghdad
- Target Recruit Count
- 160
- Registration Number
- NCT05151614
- Locations
- 🇮🇶
University of Baghdad, Baghdad, Iraq
Effect of Inflammasome Inhibitor on hsCRP in Patients After PCI
- Conditions
- NLRP3Percutaneous Coronary InterventionhsCRP
- Interventions
- First Posted Date
- 2021-11-23
- Last Posted Date
- 2023-02-08
- Lead Sponsor
- Wuhan Union Hospital, China
- Target Recruit Count
- 132
- Registration Number
- NCT05130892
- Locations
- 🇨🇳
Wuhan Union Hospital, Wuhan, Hubei, China
🇨🇳Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
Adding Colchicine to Tocilizumab in Patients With Severe COVID-19 Pneumonia.
- First Posted Date
- 2021-11-12
- Last Posted Date
- 2021-12-03
- Lead Sponsor
- Hamad Medical Corporation
- Target Recruit Count
- 230
- Registration Number
- NCT05118737
- Locations
- 🇶🇦
Alaa Rahal, Doha, DA, Qatar
Drug Development Updates
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