Pyridostigmine
- Generic Name
- Pyridostigmine
- Brand Names
- Mestinon, Regonol
- Drug Type
- Small Molecule
- Chemical Formula
- C9H13N2O2
- CAS Number
- 155-97-5
- Unique Ingredient Identifier
- 19QM69HH21
- Background
Myasthenia gravis is an autoimmune disease involving dysfunction at the neuromuscular junction, most commonly due to autoantibodies directed against the acetylcholine receptor (AChR), which results in muscle tone loss, muscle weakness, and fatigue. Acetylcholinesterase inhibitors have been the symptomatic treatment of choice in myasthenia gravis since the 19...
- Indication
Pyridostigmine is indicated for the treatment of myasthenia gravis. When administered intravenously, it is indicated for the reversal or antagonism of the neuromuscular blocking effects of nondepolarizing muscle relaxants.
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- Associated Conditions
- Congenital Myasthenia (CM), Constipation, Myasthenia Gravis, Neuromuscular Blockade, Post-Poliomyelitis Syndrome, Orthostatic syncope, Soman nerve gas poisoning
- Associated Therapies
- -
Cardiovagal Baroreflex Deficits Impair Neurovascular Coupling and Cognition in POTS
- Conditions
- Interventions
- First Posted Date
- 2017-08-25
- Last Posted Date
- 2022-09-28
- Lead Sponsor
- New York Medical College
- Target Recruit Count
- 51
- Registration Number
- NCT03261570
- Locations
- 🇺🇸
New York Medical College/Bradhurst building, Hawthorne, New York, United States
AchE Inhibitor and Insulin
- First Posted Date
- 2017-02-24
- Last Posted Date
- 2019-02-27
- Lead Sponsor
- University of Miami
- Target Recruit Count
- 12
- Registration Number
- NCT03063515
- Locations
- 🇺🇸
Diabetes Research Institute, Miami, Florida, United States
SPACE Trial: Pyridostigmine vs Placebo in SMA Types 2, 3 and 4
- Conditions
- Interventions
- First Posted Date
- 2016-10-21
- Last Posted Date
- 2018-02-05
- Lead Sponsor
- UMC Utrecht
- Target Recruit Count
- 39
- Registration Number
- NCT02941328
- Locations
- 🇳🇱
University Medical Center of Utrecht (UMCU), Utrecht, Netherlands
The Effects of Normalizing Blood Pressure on Cerebral Blood Flow in Hypotensive Individuals With Spinal Cord Injury
- Conditions
- Interventions
- First Posted Date
- 2016-09-08
- Last Posted Date
- 2024-09-30
- Lead Sponsor
- James J. Peters Veterans Affairs Medical Center
- Target Recruit Count
- 21
- Registration Number
- NCT02893553
- Locations
- 🇺🇸
James J Peters VAMC, Bronx, New York, United States
🇺🇸Kessler Foundation Research Center, West Orange, New Jersey, United States
Autonomic Neuropathy, GI Motility, and Inflammation in HIV
- First Posted Date
- 2016-07-29
- Last Posted Date
- 2019-05-29
- Lead Sponsor
- Icahn School of Medicine at Mount Sinai
- Target Recruit Count
- 76
- Registration Number
- NCT02850276
- Locations
- 🇺🇸
Icahn School of Medicine at Mount Sinai, New York, New York, United States
A Pilot Study of Pyridostigmine in Pompe Disease
- First Posted Date
- 2015-02-06
- Last Posted Date
- 2018-05-15
- Lead Sponsor
- University of Florida
- Target Recruit Count
- 2
- Registration Number
- NCT02357225
- Locations
- 🇺🇸
University of Florida Clinical Research Center, Gainesville, Florida, United States
Acetylcholinesterase Inhibition and Orthostatic Hypotension in SCI
- Conditions
- Interventions
- First Posted Date
- 2014-12-04
- Last Posted Date
- 2017-07-21
- Lead Sponsor
- James J. Peters Veterans Affairs Medical Center
- Target Recruit Count
- 10
- Registration Number
- NCT02307526
- Locations
- 🇺🇸
Kessler Institute for Rehabilitation, West Orange, New Jersey, United States
Treatment and Prognosis of Neurogenic Orthostatic Hypotension : A Prospective Randomized Study
- Conditions
- Interventions
- First Posted Date
- 2014-12-04
- Last Posted Date
- 2021-10-19
- Lead Sponsor
- Seoul National University Hospital
- Target Recruit Count
- 87
- Registration Number
- NCT02308124
- Locations
- 🇰🇷
Seoul National University Hospital, Seoul, Korea, Republic of
Safety and Efficacy Study of Pyridostigmine on Patients With Spinal Muscular Atrophy Type 3
- First Posted Date
- 2014-08-28
- Last Posted Date
- 2023-10-11
- Lead Sponsor
- Centre Hospitalier Régional de la Citadelle
- Target Recruit Count
- 4
- Registration Number
- NCT02227823
- Locations
- 🇧🇪
Centre de référence des maladies neuromusculaire, Centre Hospitalier Régional de la Citadelle, Liège, Belgium
Orthostatic Dysregulation and Associated Gastrointestinal Dysfunction in Parkinson's Disease -Treatment
- Conditions
- Interventions
- First Posted Date
- 2013-11-25
- Last Posted Date
- 2021-01-25
- Lead Sponsor
- Christian Baumann
- Target Recruit Count
- 18
- Registration Number
- NCT01993680
- Locations
- 🇨🇭
University Hospital Zurich, Division of Neurology, Zurich, ZH, Switzerland
Drug Development Updates
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