Pyridostigmine
- Generic Name
- Pyridostigmine
- Brand Names
- Mestinon, Regonol
- Drug Type
- Small Molecule
- Chemical Formula
- C9H13N2O2
- CAS Number
- 155-97-5
- Unique Ingredient Identifier
- 19QM69HH21
- Background
Myasthenia gravis is an autoimmune disease involving dysfunction at the neuromuscular junction, most commonly due to autoantibodies directed against the acetylcholine receptor (AChR), which results in muscle tone loss, muscle weakness, and fatigue. Acetylcholinesterase inhibitors have been the symptomatic treatment of choice in myasthenia gravis since the 19...
- Indication
Pyridostigmine is indicated for the treatment of myasthenia gravis. When administered intravenously, it is indicated for the reversal or antagonism of the neuromuscular blocking effects of nondepolarizing muscle relaxants.
...
- Associated Conditions
- Congenital Myasthenia (CM), Constipation, Myasthenia Gravis, Neuromuscular Blockade, Post-Poliomyelitis Syndrome, Orthostatic syncope, Soman nerve gas poisoning
- Associated Therapies
- -
Safety Study of Pyridostigmine in Heart Failure
- First Posted Date
- 2011-08-12
- Last Posted Date
- 2017-07-31
- Lead Sponsor
- NYU Langone Health
- Target Recruit Count
- 33
- Registration Number
- NCT01415921
- Locations
- 🇺🇸
New York University Langone Medical Center, New York, New York, United States
Droxidopa / Pyridostigmine in Orthostatic Hypotension
- Conditions
- Interventions
- First Posted Date
- 2011-06-10
- Last Posted Date
- 2024-06-06
- Lead Sponsor
- Mayo Clinic
- Target Recruit Count
- 30
- Registration Number
- NCT01370512
- Locations
- 🇺🇸
Mayo Clinic in Rochester, Rochester, Minnesota, United States
Pyridostigmine and Its Effects on Autonomic Modulation in Diabetic Patients
- Conditions
- Interventions
- First Posted Date
- 2009-08-06
- Last Posted Date
- 2011-07-07
- Lead Sponsor
- Hospital de Clinicas de Porto Alegre
- Target Recruit Count
- 40
- Registration Number
- NCT00953914
- Locations
- 🇧🇷
Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil
Testing Mestinon and Exercise in Fibromyalgia
- Conditions
- Interventions
- First Posted Date
- 2007-09-26
- Last Posted Date
- 2011-04-18
- Lead Sponsor
- Oregon Health and Science University
- Target Recruit Count
- 178
- Registration Number
- NCT00535587
- Locations
- 🇺🇸
Oregon Health & Science University, Portland, Oregon, United States
A Study of Pyridostigmine in Postural Tachycardia Syndrome
- Conditions
- Interventions
- First Posted Date
- 2006-12-08
- Last Posted Date
- 2024-03-13
- Lead Sponsor
- Mayo Clinic
- Target Recruit Count
- 50
- Registration Number
- NCT00409435
- Locations
- 🇺🇸
Mayo Clinic, Rochester, Minnesota, United States
Use of Pyridostigmine for Constipation in Diabetics
- Conditions
- Interventions
- First Posted Date
- 2006-01-13
- Last Posted Date
- 2012-11-30
- Lead Sponsor
- Mayo Clinic
- Target Recruit Count
- 30
- Registration Number
- NCT00276406
- Locations
- 🇺🇸
Mayo Clinic, Rochester, Minnesota, United States
Treatment of Orthostatic Hypotension in Autonomic Failure
- Conditions
- Interventions
- Drug: AtomoxetineDrug: placeboDrug: AcarboseDevice: inflatable abdominal binder (sham)Drug: Pyridostigmine BromideDrug: YohimbineDrug: Midodrine HClDrug: ModafinilDrug: OctreotideOther: water intakeDrug: Diphenhydramine HydrochlorideDrug: Ranitidine HCLDrug: TranylcypromineDrug: Ergotamine/ CaffeineDrug: CelecoxibDrug: PseudoephedrineDrug: MethylphenidateDrug: IndomethacinDrug: IbuprofenDrug: Oxymetazoline 0.05% nasal solutionDietary Supplement: BovrilDrug: AcetazolamideDrug: Rivastigmine tartrateDrug: Carbidopa/levodopaDevice: Inflatable abdominal binder
- First Posted Date
- 2005-09-22
- Last Posted Date
- 2017-01-18
- Lead Sponsor
- Vanderbilt University
- Target Recruit Count
- 389
- Registration Number
- NCT00223691
- Locations
- 🇺🇸
Vanderbilt University, Nashville, Tennessee, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.