Parecoxib

Generic Name: Parecoxib

Brand Names: Dynastat

Drug Type: Small Molecule

Chemical Formula: C_₁₉H_₁₈N_₂O_₄S

CAS Number: 198470-84-7

Unique Ingredient Identifier: 9TUW81Y3CE

Background: Parecoxib is a water-soluble and injectable prodrug of valdecoxib. It is marketed as Dynastat in the European Union. Parecoxib is a COX2 selective inhibitor in the same category as celecoxib (Celebrex) and rofecoxib (Vioxx). As it is injectable, it can be used perioperatively when patients are unable to take oral medications. It is approved through much of E...

Indication: Used for short term perioperative pain control.

Associated Conditions: Postoperative pain

Associated Therapies: -

Clinical Trials

A Randomized, Single-dose, Two-way Crossover Study to Evaluate Bioequivalence of Two Formulations of Parecoxib After Intravenous Bolus of Parecoxib in Healthy Volunteers Under Fasting Conditions

Phase 4

Not yet recruiting

Conditions: Post-operative Pain
Bioequivalence Study in Healthy Subjects

Interventions: Drug: Parecoxib

First Posted Date: 2024-09-19

Last Posted Date: 2024-09-19

Lead Sponsor: Yung Shin Pharm. Ind. Co., Ltd.

Target Recruit Count: 14

Registration Number: NCT06600282

Locations: 🇨🇳
Taichung Veterans General Hospital, Taichung, Taiwan

Evaluation of the Safety and Efficacy of Parecoxib in Patients With Subarachnoid Hemorrhage

Phase 2

Not yet recruiting

Conditions: Neurological Complication

Interventions: Drug: Placebo
Drug: Parecoxib

First Posted Date: 2024-08-30

Last Posted Date: 2024-08-30

Lead Sponsor: St. Anne's University Hospital Brno, Czech Republic

Target Recruit Count: 112

Registration Number: NCT06579274

Locations: 🇨🇿
St. Anne's University Hospital Brno, Brno, Czech Republic, Czechia

Analgesic Effect of Parecoxib Versus Morphine in SCD Patients Presenting to the Emergency Department

Phase 3

Not yet recruiting

Conditions: Sickle-Cell Disease With Crisis

Interventions: Drug: Parecoxib
Drug: Morphine

First Posted Date: 2024-03-18

Last Posted Date: 2024-03-18

Lead Sponsor: Oman Medical Speciality Board

Target Recruit Count: 226

Registration Number: NCT06315920

Effect of Paracetamol and Mannitol Injection on Postoperative Analgesia in Patients With Thoracoscopic Lobectomy

Not Applicable

Not yet recruiting

Conditions: Postoperative Analgesia

Interventions: Drug: Paracetamol and Mannitol Injection
Drug: Parecoxib

First Posted Date: 2024-03-12

Last Posted Date: 2024-03-12

Lead Sponsor: The Fourth Affiliated Hospital of Zhejiang University School of Medicine

Target Recruit Count: 90

Registration Number: NCT06304181

Preemptive Analgesic Efficacy of Parecoxib for Reducing Postoperative Pain in Gynecological Surgery

Phase 4

Completed

Conditions: Parecoxib
Preemptive Analgesia
Gynecological Surgery
Postoperative Pain

Interventions: Drug: Normal saline
Drug: Parecoxib

First Posted Date: 2023-11-18

Last Posted Date: 2024-11-14

Lead Sponsor: Rajavithi Hospital

Target Recruit Count: 178

Registration Number: NCT06140238

Locations: 🇹🇭
Rajavithi Hospital, Bangkok, Thailand

Optimized Acute Pain Control With Parecoxib in Uniportal Video-assisted Thoracoscopic Surgery.

Phase 4

Completed

Conditions: Perioperative Care
Chronic Post-operative Pain

Interventions: Drug: Placebo
Drug: Parecoxib

First Posted Date: 2021-12-09

Last Posted Date: 2023-08-02

Lead Sponsor: National Taiwan University Hospital

Target Recruit Count: 58

Registration Number: NCT05150431

Locations: 🇨🇳
National Taiwan University Cancer Center, Taipei, Taiwan

Parecoxib vs. Dexketoprofen for the Management of Pain After Cesarean Section.

Not Applicable

Completed

Conditions: Caesarean Section; Pain

Interventions: Drug: Parecoxib
Drug: Dexketoprofen

First Posted Date: 2021-04-15

Last Posted Date: 2021-10-11

Lead Sponsor: Saint Thomas Hospital, Panama

Target Recruit Count: 380

Registration Number: NCT04847024

Locations: 🇵🇦
Saint Thomas H, Panama, Panama

Parecoxib vs Paracetamol in the Treatment of Acute Renal Colic

Phase 4

Completed

Conditions: Acute Renal Colic
Ureteric Stone

Interventions: Drug: Paracetamol
Drug: Parecoxib

First Posted Date: 2018-10-15

Last Posted Date: 2020-08-28

Lead Sponsor: Mansoura University

Target Recruit Count: 200

Registration Number: NCT03704623

Locations: 🇰🇼
Al-Amiri Hospital, Kuwait, Kuwait

The Epigenetic Modification in OPRM1 on Postoperative Analgesia and Side Effect Induced by Sufentanil

Phase 4

Conditions: Epigenetics

Interventions: Drug: Sufentanil
Drug: dexmedetomidine
Drug: propofol
Drug: Rocuronium
Drug: sevoflurane
Drug: remifentanil
Drug: Parecoxib

First Posted Date: 2017-05-01

Last Posted Date: 2017-05-01

Lead Sponsor: Huazhong University of Science and Technology

Target Recruit Count: 100

Registration Number: NCT03135795

Locations: 🇨🇳
Department of Anaesthesiology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

Early Parecoxib Usage to Decreases Narcotic Requirement and Length of Stay After Traumatic Rib Fracture

Phase 3

Terminated

Conditions: Parecoxib
Rib Fractures

Interventions: Drug: Parecoxib
Drug: Morphine

First Posted Date: 2016-04-25

Last Posted Date: 2020-01-31

Lead Sponsor: Chang Gung Memorial Hospital

Target Recruit Count: 17

Registration Number: NCT02749409

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