Parecoxib
- Generic Name
- Parecoxib
- Brand Names
- Dynastat
- Drug Type
- Small Molecule
- Chemical Formula
- C19H18N2O4S
- CAS Number
- 198470-84-7
- Unique Ingredient Identifier
- 9TUW81Y3CE
- Background
Parecoxib is a water-soluble and injectable prodrug of valdecoxib. It is marketed as Dynastat in the European Union. Parecoxib is a COX2 selective inhibitor in the same category as celecoxib (Celebrex) and rofecoxib (Vioxx). As it is injectable, it can be used perioperatively when patients are unable to take oral medications. It is approved through much of Europe for short term perioperative pain control much in the same way ketorolac (Toradol) is used in the United States. A letter of non-approval for parecoxib was issued by the FDA in 2005.
- Indication
Used for short term perioperative pain control.
- Associated Conditions
- Postoperative pain
Efficacy and Safety of Parecoxib vs. Indomethacin in Preventing Post-ERCP Pancreatitis
- Conditions
- Pancreatitis, AcuteCholangiopancreatography, Endoscopic Retrograde
- Interventions
- First Posted Date
- 2024-10-02
- Last Posted Date
- 2024-10-02
- Lead Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
- Target Recruit Count
- 100
- Registration Number
- NCT06623513
A Randomized, Single-dose, Two-way Crossover Study to Evaluate Bioequivalence of Two Formulations of Parecoxib After Intravenous Bolus of Parecoxib in Healthy Volunteers Under Fasting Conditions
- Conditions
- Post-operative PainBioequivalence Study in Healthy Subjects
- Interventions
- First Posted Date
- 2024-09-19
- Last Posted Date
- 2024-09-19
- Lead Sponsor
- Yung Shin Pharm. Ind. Co., Ltd.
- Target Recruit Count
- 14
- Registration Number
- NCT06600282
- Locations
- 🇨🇳
Taichung Veterans General Hospital, Taichung, Taiwan
Evaluation of the Safety and Efficacy of Parecoxib in Patients With Subarachnoid Hemorrhage
- Conditions
- Neurological Complication
- Interventions
- Drug: Placebo
- First Posted Date
- 2024-08-30
- Last Posted Date
- 2024-08-30
- Lead Sponsor
- St. Anne's University Hospital Brno, Czech Republic
- Target Recruit Count
- 112
- Registration Number
- NCT06579274
- Locations
- 🇨🇿
St. Anne's University Hospital Brno, Brno, Czech Republic, Czechia
Analgesic Effect of Parecoxib Versus Morphine in SCD Patients Presenting to the Emergency Department
- Conditions
- Sickle-Cell Disease with Crisis
- Interventions
- First Posted Date
- 2024-03-18
- Last Posted Date
- 2025-03-20
- Lead Sponsor
- Oman Medical Speciality Board
- Target Recruit Count
- 226
- Registration Number
- NCT06315920
Effect of Paracetamol and Mannitol Injection on Postoperative Analgesia in Patients With Thoracoscopic Lobectomy
- Conditions
- Postoperative Analgesia
- Interventions
- First Posted Date
- 2024-03-12
- Last Posted Date
- 2024-03-12
- Lead Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
- Target Recruit Count
- 90
- Registration Number
- NCT06304181
Preemptive Analgesic Efficacy of Parecoxib for Reducing Postoperative Pain in Gynecological Surgery
- Conditions
- ParecoxibPreemptive AnalgesiaGynecological SurgeryPostoperative Pain
- Interventions
- Drug: Normal saline
- First Posted Date
- 2023-11-18
- Last Posted Date
- 2024-11-14
- Lead Sponsor
- Rajavithi Hospital
- Target Recruit Count
- 178
- Registration Number
- NCT06140238
- Locations
- 🇹🇭
Rajavithi Hospital, Bangkok, Thailand
Efficacy of Parecoxib Combined With Paracetamol in Mastectomy
- Conditions
- Post Operative Pain
- Interventions
- Drug: Normal saline
- First Posted Date
- 2023-03-07
- Last Posted Date
- 2023-04-14
- Lead Sponsor
- Khon Kaen University
- Target Recruit Count
- 60
- Registration Number
- NCT05757388
- Locations
- 🇹🇭
Dr. Sirirat Tribuddharat, Khon Kaen, Thailand
Optimized Acute Pain Control With Parecoxib in Uniportal Video-assisted Thoracoscopic Surgery.
- Conditions
- Perioperative CareChronic Post-operative Pain
- Interventions
- Drug: Placebo
- First Posted Date
- 2021-12-09
- Last Posted Date
- 2023-08-02
- Lead Sponsor
- National Taiwan University Hospital
- Target Recruit Count
- 58
- Registration Number
- NCT05150431
- Locations
- 🇨🇳
National Taiwan University Cancer Center, Taipei, Taiwan
Parecoxib vs. Dexketoprofen for the Management of Pain After Cesarean Section.
- Conditions
- Caesarean Section; Pain
- Interventions
- First Posted Date
- 2021-04-15
- Last Posted Date
- 2021-10-11
- Lead Sponsor
- Saint Thomas Hospital, Panama
- Target Recruit Count
- 380
- Registration Number
- NCT04847024
- Locations
- 🇵🇦
Saint Thomas H, Panama, Panama
Effect of Intravenous Dynastat on Postoperative Sore Throat
- Conditions
- Sore ThroatPostoperative Complications
- Interventions
- Drug: Normal saline
- First Posted Date
- 2019-04-16
- Last Posted Date
- 2019-04-16
- Lead Sponsor
- Buddhist Tzu Chi General Hospital
- Target Recruit Count
- 140
- Registration Number
- NCT03915561
- Locations
- 🇨🇳
Po-Kai Wang, Hualien City, Hualien, Taiwan
Drug Development Updates
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