Parecoxib

Generic Name: Parecoxib

Brand Names: Dynastat

Drug Type: Small Molecule

Chemical Formula: C_₁₉H_₁₈N_₂O_₄S

CAS Number: 198470-84-7

Unique Ingredient Identifier: 9TUW81Y3CE

Background: Parecoxib is a water-soluble and injectable prodrug of valdecoxib. It is marketed as Dynastat in the European Union. Parecoxib is a COX2 selective inhibitor in the same category as celecoxib (Celebrex) and rofecoxib (Vioxx). As it is injectable, it can be used perioperatively when patients are unable to take oral medications. It is approved through much of Europe for short term perioperative pain control much in the same way ketorolac (Toradol) is used in the United States. A letter of non-approval for parecoxib was issued by the FDA in 2005.

Indication: Used for short term perioperative pain control.

Associated Conditions: Postoperative pain

Clinical Trials

the Effect of Doctor-nurse-patient Cooperative Analgesic Linkage Program on Movement Evoked Pain

Not Applicable

Conditions: Pain, Postoperative
Anaplasia

Interventions: Drug: Adjusted Dezocine injection
Drug: Routine Dezocine injection
Drug: Routine Dynastat or Flurbiprofen Axetil jinjection
Drug: Adjusted Dynastat or Flurbiprofen Axetil jinjection
Other: postoperative rehabilitation
Drug: adjusted analgesia pump administration
Drug: normal analgesia pump administration

First Posted Date: 2019-01-31

Last Posted Date: 2020-02-12

Lead Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University

Target Recruit Count: 80

Registration Number: NCT03823846

Locations: 🇨🇳
Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China

Parecoxib vs Paracetamol in the Treatment of Acute Renal Colic

Phase 4

Completed

Conditions: Acute Renal Colic
Ureteric Stone

Interventions: Drug: Paracetamol
Drug: Parecoxib

First Posted Date: 2018-10-15

Last Posted Date: 2020-08-28

Lead Sponsor: Mansoura University

Target Recruit Count: 200

Registration Number: NCT03704623

Locations: 🇰🇼
Al-Amiri Hospital, Kuwait, Kuwait

The Efficacy of 20 mg Parecoxib as an Adjunct to 0.75% Ropivacaine in Supraclavicular Brachial Plexus Block for Upper Limb Surgery

Phase 3

Completed

Conditions: Anesthesia; Functional
Anesthesia

Interventions: Drug: Parecoxib 20 MG/ML
Drug: Ropivacaine

First Posted Date: 2018-03-29

Last Posted Date: 2018-03-29

Lead Sponsor: Universiti Sains Malaysia

Target Recruit Count: 86

Registration Number: NCT03480165

Locations: 🇲🇾
Hospital Universiti Sains Malaysia (HUSM), Kubang Kerian, Kelantan, Malaysia

The Epigenetic Modification in OPRM1 on Postoperative Analgesia and Side Effect Induced by Sufentanil

Phase 4

Conditions: Epigenetics

Interventions: Drug: Sufentanil
Drug: dexmedetomidine
Drug: propofol
Drug: Rocuronium
Drug: sevoflurane
Drug: remifentanil
Drug: Parecoxib

First Posted Date: 2017-05-01

Last Posted Date: 2017-05-01

Lead Sponsor: Huazhong University of Science and Technology

Target Recruit Count: 100

Registration Number: NCT03135795

Locations: 🇨🇳
Department of Anaesthesiology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

Parecoxib Versus Celecoxib Versus Oxycodone in Pain Control for Transcatheter Chemoembolization Procedure

Phase 3

Completed

Conditions: Pain Postoperative
Liver Cancer

Interventions: Drug: controlled-release oxycodone
Drug: parecoxib sodium
Drug: Celecoxib 200mg oral capsule

First Posted Date: 2017-02-23

Last Posted Date: 2019-08-13

Lead Sponsor: Sun Yat-sen University

Target Recruit Count: 213

Registration Number: NCT03059238

Locations: 🇨🇳
Minimally Invasive Interventional Division, Department of Medical Imaging and Interventional Radiology, Sun Yat-sen University Cancer Center,, Guangzhou, Guangdong, China