Parecoxib

Generic Name: Parecoxib

Brand Names: Dynastat

Drug Type: Small Molecule

Chemical Formula: C_₁₉H_₁₈N_₂O_₄S

CAS Number: 198470-84-7

Unique Ingredient Identifier: 9TUW81Y3CE

Background: Parecoxib is a water-soluble and injectable prodrug of valdecoxib. It is marketed as Dynastat in the European Union. Parecoxib is a COX2 selective inhibitor in the same category as celecoxib (Celebrex) and rofecoxib (Vioxx). As it is injectable, it can be used perioperatively when patients are unable to take oral medications. It is approved through much of E...

Indication: Used for short term perioperative pain control.

Associated Conditions: Postoperative pain

Associated Therapies: -

Clinical Trials

Parecoxib for Treatment of Catheter Related Bladder Discomfort

Phase 4

Completed

Conditions: Postoperative Pain

Interventions: Drug: Placebo
Drug: Parecoxib

First Posted Date: 2016-04-06

Last Posted Date: 2016-10-18

Lead Sponsor: University Tunis El Manar

Target Recruit Count: 60

Registration Number: NCT02729935

Locations: 🇹🇳
Ali JENDOUBI, Tunis, Tunisia

The Effect of Parecoxib Sodium Intravenous Patient-controlled Analgesia in Laparotomic Liver Resection

Not Applicable

Conditions: Pain, Postoperative

Interventions: Procedure: conventional intravenous infusion pump
Drug: parecoxib
Procedure: intravenous infusion pump of patient-controlled analgesia
Drug: fentanyl citrate+ ondansetron hydrochloride + normal saline
Drug: celecoxib

First Posted Date: 2015-04-03

Last Posted Date: 2015-04-03

Lead Sponsor: First Affiliated Hospital of Harbin Medical University

Target Recruit Count: 80

Registration Number: NCT02408146

Locations: 🇨🇳
harbin Medical University, Harbin, Heilongjiang, China

Combination of Continuous Femoral Block and Intravenous Parecoxib For Postoperative Analgesia After Total Knee Arthroplasty

Phase 2

Completed

Conditions: POSTOPERATIVE ANALGESIA FOR TKA PARECOXIB/CFB

Interventions: Drug: CONTINUOUS FEMORAL BLOCK WITH ROPIVACAINE 0,2%
Drug: Parecoxib
Drug: N/S 0.9%

First Posted Date: 2014-07-10

Last Posted Date: 2014-07-10

Lead Sponsor: Asklepieion Voulas General Hospital

Target Recruit Count: 90

Registration Number: NCT02185924

Locations: 🇬🇷
Department of Anaesthesia Asklepeion Voulas General Hospital, Voula Athens, Greece

Effect of COX-2 Selective Inhibitors on Postoperative Insulin Resistance After Gastrointestinal Laparoscopic Surgery

Phase 4

Conditions: Gastrointestinal Cancer

Interventions: Drug: parecoxib

First Posted Date: 2013-08-28

Last Posted Date: 2014-11-10

Lead Sponsor: Jinling Hospital, China

Target Recruit Count: 164

Registration Number: NCT01930318

Locations: 🇨🇳
Jinling Hospital, Nanjing, Jiangsu, China

Efficacy Parecoxib and Ketorolac as Preemptive Analgesia in Spine Fusion

Phase 4

Completed

Conditions: Postoperative Pain

Interventions: Drug: Parecoxib
Drug: Ketorolac

First Posted Date: 2013-05-22

Last Posted Date: 2013-05-22

Lead Sponsor: Prince of Songkla University

Target Recruit Count: 96

Registration Number: NCT01859585

Locations: 🇹🇭
Faculty of Medicine, Prince of Songkla University, Hadyai, Sonkla, Thailand

Effect of Parecoxib on the Change of Shoulder Pain Threshold After Gynecological Laparoscopies

Phase 4

Completed

Conditions: Postoperative Pain Management, Pain Threshold, Shoulder Pain, Laparoscopies

Interventions: Drug: Parecoxib
Drug: Placebo

First Posted Date: 2013-04-30

Last Posted Date: 2014-02-19

Lead Sponsor: First Affiliated Hospital, Sun Yat-Sen University

Target Recruit Count: 140

Registration Number: NCT01843010

Locations: 🇨🇳
Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University., Guangzhou, Guangdong, China

Perioperative Electroacupuncture on Postoperative Analgesia in Prostatectomy

Phase 4

Completed

Conditions: Pain, Postoperative

Interventions: Drug: Tramadol
Drug: Ketamine
Drug: Morphine
Procedure: sedation
Procedure: rescue analgesia
Drug: Parecoxib
Drug: paracetamol

First Posted Date: 2012-02-06

Last Posted Date: 2014-02-21

Lead Sponsor: G.Gennimatas General Hospital

Target Recruit Count: 70

Registration Number: NCT01526525

Locations: 🇬🇷
G.Gennimatas GENERAL HOSPITAL OF THESSALONIKI, Thessaloniki, Greece

Efficacy of Parecoxib on Patients With CRPS

Conditions: Causalgia

First Posted Date: 2012-02-01

Last Posted Date: 2012-04-25

Lead Sponsor: Ruhr University of Bochum

Registration Number: NCT01523379

Effect of Parecoxib on Postoperative Shoulder Pain After Gynecological Laparoscopy.

Not Applicable

Completed

Conditions: Anti-Inflammatory Agents, Non-Steroidal
Pain, Postoperative
Laparoscopy

Interventions: Drug: parecoxib

First Posted Date: 2011-07-13

Last Posted Date: 2011-11-22

Lead Sponsor: First Affiliated Hospital, Sun Yat-Sen University

Target Recruit Count: 126

Registration Number: NCT01393925

Locations: 🇨🇳
Department of Anesthesiology,,The first affiliated hospital of Sun Yat-Sen university, Guangzhou, Guangdong, China

Can Parecoxib Reduce Post-operative Ipsilateral Shoulder Pain?

Phase 2

Completed

Conditions: Post-operative Pain
Shoulder Pain

Interventions: Other: Control
Drug: Parecoxib

First Posted Date: 2011-02-03

Last Posted Date: 2016-12-06

Lead Sponsor: Chiang Mai University

Target Recruit Count: 160

Registration Number: NCT01288924

Locations: 🇹🇭
Department of Anesthesiology, Faculty of Medicine, Maung, Chiang Mai, Thailand
🇹🇭
Department of Anesthesiology, Faculty of Medicine, Chiang Mai University, Maung, Chiang Mai, Thailand

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