Parecoxib
- Generic Name
- Parecoxib
- Brand Names
- Dynastat
- Drug Type
- Small Molecule
- Chemical Formula
- C19H18N2O4S
- CAS Number
- 198470-84-7
- Unique Ingredient Identifier
- 9TUW81Y3CE
- Background
Parecoxib is a water-soluble and injectable prodrug of valdecoxib. It is marketed as Dynastat in the European Union. Parecoxib is a COX2 selective inhibitor in the same category as celecoxib (Celebrex) and rofecoxib (Vioxx). As it is injectable, it can be used perioperatively when patients are unable to take oral medications. It is approved through much of Europe for short term perioperative pain control much in the same way ketorolac (Toradol) is used in the United States. A letter of non-approval for parecoxib was issued by the FDA in 2005.
- Indication
Used for short term perioperative pain control.
- Associated Conditions
- Postoperative pain
Parecoxib for Pain Management After Total Knee Arthroplasty and Total Hip Arthroplasty
- Conditions
- Pain, Postoperative
- Interventions
- Drug: Normal saline injection
- First Posted Date
- 2014-10-23
- Last Posted Date
- 2015-08-28
- Lead Sponsor
- Peking Union Medical College Hospital
- Target Recruit Count
- 74
- Registration Number
- NCT02272660
- Locations
- 🇨🇳
The Peking Union Medical College Hospital, Beijing, Beijing, China
Role of Parecoxib Sodium for Postoperative Pain Management in Open Hepatectomy
- Conditions
- Laparotomy SurgeryHepatic Hemangioma Located in the Right Liver
- Interventions
- First Posted Date
- 2014-07-30
- Last Posted Date
- 2014-07-30
- Lead Sponsor
- Peking Union Medical College Hospital
- Target Recruit Count
- 100
- Registration Number
- NCT02204878
- Locations
- 🇨🇳
Peking union medical college hospital, Beijing, Beijing, China
Efficacy and Safety of Postoperative Intravenous Parecoxib Sodium Followed by Oral Celecoxib in Osteoarthritis Patients
- First Posted Date
- 2014-07-24
- Last Posted Date
- 2019-04-19
- Lead Sponsor
- Peking Union Medical College Hospital
- Target Recruit Count
- 246
- Registration Number
- NCT02198924
- Locations
- 🇨🇳
Peking Union Medical College Hospital, Beijing, China
Combination of Continuous Femoral Block and Intravenous Parecoxib For Postoperative Analgesia After Total Knee Arthroplasty
- Conditions
- POSTOPERATIVE ANALGESIA FOR TKA PARECOXIB/CFB
- Interventions
- First Posted Date
- 2014-07-10
- Last Posted Date
- 2014-07-10
- Lead Sponsor
- Asklepieion Voulas General Hospital
- Target Recruit Count
- 90
- Registration Number
- NCT02185924
- Locations
- 🇬🇷
Department of Anaesthesia Asklepeion Voulas General Hospital, Voula Athens, Greece
Effect of COX-2 Selective Inhibitors on Postoperative Insulin Resistance After Gastrointestinal Laparoscopic Surgery
- First Posted Date
- 2013-08-28
- Last Posted Date
- 2014-11-10
- Lead Sponsor
- Jinling Hospital, China
- Target Recruit Count
- 164
- Registration Number
- NCT01930318
- Locations
- 🇨🇳
Jinling Hospital, Nanjing, Jiangsu, China
Efficacy Parecoxib and Ketorolac as Preemptive Analgesia in Spine Fusion
- First Posted Date
- 2013-05-22
- Last Posted Date
- 2013-05-22
- Lead Sponsor
- Prince of Songkla University
- Target Recruit Count
- 96
- Registration Number
- NCT01859585
- Locations
- 🇹🇭
Faculty of Medicine, Prince of Songkla University, Hadyai, Sonkla, Thailand
Effect of Parecoxib on the Change of Shoulder Pain Threshold After Gynecological Laparoscopies
- Conditions
- Postoperative Pain Management, Pain Threshold, Shoulder Pain, Laparoscopies
- Interventions
- Drug: Placebo
- First Posted Date
- 2013-04-30
- Last Posted Date
- 2014-02-19
- Lead Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
- Target Recruit Count
- 140
- Registration Number
- NCT01843010
- Locations
- 🇨🇳
Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University., Guangzhou, Guangdong, China
Efficacy and Safety of Parecoxib on Morphine Patient-controlled Epidural Analgesia (PCEA) After Gynecologic Surgery
- Conditions
- Benign Female Reproductive System Neoplasm
- Interventions
- Drug: Normal saline
- First Posted Date
- 2012-03-29
- Last Posted Date
- 2012-09-24
- Lead Sponsor
- Liu Weifeng
- Target Recruit Count
- 294
- Registration Number
- NCT01566669
- Locations
- 🇨🇳
The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China
Perioperative Electroacupuncture on Postoperative Analgesia in Prostatectomy
- Conditions
- Pain, Postoperative
- Interventions
- Procedure: sedationProcedure: rescue analgesia
- First Posted Date
- 2012-02-06
- Last Posted Date
- 2014-02-21
- Lead Sponsor
- G.Gennimatas General Hospital
- Target Recruit Count
- 70
- Registration Number
- NCT01526525
- Locations
- 🇬🇷
G.Gennimatas GENERAL HOSPITAL OF THESSALONIKI, Thessaloniki, Greece
Efficacy of Parecoxib on Patients With CRPS
- Conditions
- Causalgia
- First Posted Date
- 2012-02-01
- Last Posted Date
- 2012-04-25
- Lead Sponsor
- Ruhr University of Bochum
- Registration Number
- NCT01523379
Drug Development Updates
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