Parecoxib

Generic Name: Parecoxib

Brand Names: Dynastat

Drug Type: Small Molecule

Chemical Formula: C_₁₉H_₁₈N_₂O_₄S

CAS Number: 198470-84-7

Unique Ingredient Identifier: 9TUW81Y3CE

Background: Parecoxib is a water-soluble and injectable prodrug of valdecoxib. It is marketed as Dynastat in the European Union. Parecoxib is a COX2 selective inhibitor in the same category as celecoxib (Celebrex) and rofecoxib (Vioxx). As it is injectable, it can be used perioperatively when patients are unable to take oral medications. It is approved through much of Europe for short term perioperative pain control much in the same way ketorolac (Toradol) is used in the United States. A letter of non-approval for parecoxib was issued by the FDA in 2005.

Indication: Used for short term perioperative pain control.

Associated Conditions: Postoperative pain

Clinical Trials

Effect of Parecoxib on Postoperative Shoulder Pain After Gynecological Laparoscopy.

Not Applicable

Completed

Conditions: Anti-Inflammatory Agents, Non-Steroidal
Pain, Postoperative
Laparoscopy

Interventions: Drug: parecoxib

First Posted Date: 2011-07-13

Last Posted Date: 2011-11-22

Lead Sponsor: First Affiliated Hospital, Sun Yat-Sen University

Target Recruit Count: 126

Registration Number: NCT01393925

Locations: 🇨🇳
Department of Anesthesiology,,The first affiliated hospital of Sun Yat-Sen university, Guangzhou, Guangdong, China

COX-2 Inhibitor Versus Glucocorticoid Versus Both Combined

Phase 4

Completed

Conditions: Rupture of Anterior Cruciate Ligament

Interventions: Drug: parecoxib, valdecoxib, etoricoxib
Drug: Dexamethasone
Drug: parecoxib, valdecoxib, parecoxib and dexamethasone

First Posted Date: 2011-05-27

Last Posted Date: 2011-05-27

Lead Sponsor: Asker & Baerum Hospital

Target Recruit Count: 93

Registration Number: NCT01361789

Locations: 🇳🇴
Baerum Hospital, Rud, Norway

Can Parecoxib Reduce Post-operative Ipsilateral Shoulder Pain?

Phase 2

Completed

Conditions: Post-operative Pain
Shoulder Pain

Interventions: Other: Control
Drug: Parecoxib

First Posted Date: 2011-02-03

Last Posted Date: 2016-12-06

Lead Sponsor: Chiang Mai University

Target Recruit Count: 160

Registration Number: NCT01288924

Locations: 🇹🇭
Department of Anesthesiology, Faculty of Medicine, Maung, Chiang Mai, Thailand
🇹🇭
Department of Anesthesiology, Faculty of Medicine, Chiang Mai University, Maung, Chiang Mai, Thailand

Effect Study of Parecoxib to Treat Emergence Delirium and Postoperative Pain

Phase 4

Conditions: Emergence Delirium
Postoperative Pain

Interventions: Drug: Parecoxib

First Posted Date: 2010-10-14

Last Posted Date: 2011-03-25

Lead Sponsor: First Affiliated Hospital, Sun Yat-Sen University

Target Recruit Count: 900

Registration Number: NCT01221025

Locations: 🇨🇳
The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China

The Correlation of COX-2 Expression in Human Polymorphonuclear Leukocytes/Macrophages (PMNL/MP) and Postoperative Pain

Phase 4

Completed

Conditions: Post-Operative Pain

Interventions: Drug: Parecoxib Sodium

First Posted Date: 2010-08-23

Last Posted Date: 2015-04-17

Lead Sponsor: Xianwei Zhang

Target Recruit Count: 90

Registration Number: NCT01186159

Locations: 🇨🇳
Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China