Metronidazole

Generic Name
Metronidazole
Brand Names
Flagyl, Flagystatin, Likmez, Metrocream, Metrogel, Metrolotion, Nidagel, Noritate, Nuvessa, Pylera, Rosadan, Vandazole
Drug Type
Small Molecule
Chemical Formula
C6H9N3O3
CAS Number
443-48-1
Unique Ingredient Identifier
140QMO216E
Background

Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections. Metronidazole has been used as an antibiotic for several decades, with added antiparasitic properties that set it apart from many other antibacterial drugs, allowing it to treat a wide variety of infections. It is available in capsule form, tablet form, and topical form, and suppository preparations for the treatment of various infections.

Indication

Metronidazole is indicated for the treatment of confirmed trichomoniasis caused by Trichomonas vaginalis (except for in the first trimester of pregnancy) and the patient's sexual partners, bacterial vaginosis, certain types of amebiasis, and various anaerobic infections. The above anaerobic infections may occur on the skin and skin structures, the abdomen, the heart, reproductive organs, central nervous system, and the respiratory system. Some may also be present in the bloodstream in cases of septicemia. Common infections treated by metronidazole are Bacteroides species infections, Clostridium infections, and Fusobacterium infections, as well as Peptococcus and Peptostreptococcus infections. Topical formulations of metronidazole are indicated for the treatment of inflammatory lesions of rosacea.

It is also used off-label in the treatment of Crohn's disease, as a prophylactic agent after surgery, and in the treatment of Helicobacter pylori infection. It has also been studied in the prevention of preterm births and to treat periodontal disease.

Associated Conditions
Abscess Brain, Abscess, Intra-Abdominal, Anaerobic Bacterial Infection, Bacterial Endocarditis, Bacterial Peritonitis, Bacterial Septicemia, Bacterial Vaginosis (BV), Balantidiasis, Bone and Joint Infections, Central Nervous System Bacterial Infections, Empyema, Endometritis, Endomyometritis, Facial Rosacea, Giardiasis, Gynecological Infection, Helicobacter Pylori Infection, Inflammatory Papule, Inflammatory pustules, Liver Abscess, Amebic, Lower respiratory tract infection bacterial, Lung Abscess, Meningitis, Mixed Vaginal Infections, Mixed Vaginal Infections caused by Trichomonas Vaginalis, candida albicans, Periodontitis, Pneumonia, Postoperative Infections, Pouchitis, Skin and skin structure infections, Tetanus, Trichomonas Vaginitis, Tubo-ovarian abscess, Vaginal Candidiasis, Vaginitis Trichomonal, Vulvovaginitis, Acute Intestinal amebiasis, Asymptomatic Trichomoniasis, Entamoeba histolytica, Hepatic abscess, Intra-abdominal bacterial infections, Post-surgical vaginal cuff infection, Refractory Sinusitis, Symptomatic Trichomoniasis
Associated Therapies
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Dose Ranging Study of Metronidazole Vaginal Gel in the Treatment of Bacterial Vaginosis

First Posted Date
2010-01-25
Last Posted Date
2011-07-01
Lead Sponsor
Graceway Pharmaceuticals, LLC
Target Recruit Count
255
Registration Number
NCT01055106
Locations
🇺🇸

Women's Health Research, Phoenix, Arizona, United States

🇺🇸

NEA Women's Clinic, Jonesboro, Arkansas, United States

🇺🇸

Miami Research Associates, Miami, Florida, United States

and more 17 locations

Bioavailability of Metronidazole Vaginal Gel in Healthy Subjects

Phase 1
Completed
Conditions
Interventions
First Posted Date
2009-11-26
Last Posted Date
2010-06-29
Lead Sponsor
Teva Pharmaceuticals USA
Target Recruit Count
38
Registration Number
NCT01020877
Locations
🇺🇸

Novum Pharmaceutical Research Services, Pittsburgh, Pennsylvania, United States

Bioequivalence of Metronidazole Gel, 0.75% in the Treatment of Bacterial Vaginosis

Phase 1
Completed
Conditions
Interventions
First Posted Date
2009-11-25
Last Posted Date
2024-08-19
Lead Sponsor
Teva Pharmaceuticals USA
Target Recruit Count
579
Registration Number
NCT01020396
Locations
🇺🇸

Medical Affiliated Research Center, Inc., Huntsville, Alabama, United States

🇺🇸

Office of Drs. Shepard and Lugerner, PC, Washington, District of Columbia, United States

🇺🇸

Phoenix Ob-Gyn Associates, Mount Holly, New Jersey, United States

and more 33 locations

Trichomonas Vaginalis Recurrence Among HIV+ Women

Phase 4
Completed
Conditions
Interventions
First Posted Date
2009-11-23
Last Posted Date
2016-12-20
Lead Sponsor
Tulane University Health Sciences Center
Target Recruit Count
270
Registration Number
NCT01018095
Locations
🇺🇸

NOAIDS, New Orleans, Louisiana, United States

🇺🇸

HIV Outpatient Clinic, New Orleans, Louisiana, United States

🇺🇸

Crossroads Clinic, Jackson, Mississippi, United States

and more 2 locations

Comparison of 7-day and 14-day Bismuth Based Quadruple Therapy for Secondary Helicobacter Pylori Eradication

First Posted Date
2009-02-11
Last Posted Date
2016-12-06
Lead Sponsor
Asan Medical Center
Target Recruit Count
199
Registration Number
NCT00841854
Locations
🇰🇷

Asan Medical Center, Seoul, Korea, Republic of

BASIC (Boric Acid, Alternate Solution for Intravaginal Colonization) Study

First Posted Date
2008-11-27
Last Posted Date
2016-10-27
Lead Sponsor
University of British Columbia
Target Recruit Count
13
Registration Number
NCT00799214
Locations
🇨🇦

Multicentered, family practice offices, Province-wide, British Columbia, Canada

A Randomised Controlled Trial of the Use of Topical Metronidazole (10%) to Reduce Pain After Haemorrhoidectomy

Phase 2
Completed
Conditions
Interventions
First Posted Date
2008-10-17
Last Posted Date
2013-06-05
Lead Sponsor
S.L.A. Pharma AG
Target Recruit Count
59
Registration Number
NCT00774722
Locations
🇬🇧

St Marks Hospital, Harrow, United Kingdom

🇬🇧

Stepping Hill Hospital, Stockport, United Kingdom

🇬🇧

St Thomas' Hospital, Lambeth Palace Road, London, United Kingdom

and more 2 locations

Evaluation of the Pharmacokinetics of Metronidazole 10% Ointment Applied Peri Anally in Healthy Volunteers and Patients With Perianal Crohn's Disease

Phase 1
Completed
Conditions
Interventions
First Posted Date
2008-10-17
Last Posted Date
2008-10-17
Lead Sponsor
S.L.A. Pharma AG
Target Recruit Count
19
Registration Number
NCT00774969
Locations
🇬🇧

Sainsbury Wing, St Marks & Northwick Park Hospitals, Watford Road, Harrow, United Kingdom

Efficacy and Safety Trial to Assess Moxifloxacin in Treating Community-Acquired Pneumonia (CAP) With Aspiration Factors

First Posted Date
2008-09-16
Last Posted Date
2009-03-11
Lead Sponsor
Beijing Hospital
Target Recruit Count
186
Registration Number
NCT00752947
Locations
🇨🇳

Tieying Sun, Beijing, China

🇨🇳

Xiuhong Nie, Beijing, China

Inflammation and Treatment of Bacterial Vaginosis Near Term

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2008-07-22
Last Posted Date
2018-07-27
Lead Sponsor
Medical University of South Carolina
Target Recruit Count
59
Registration Number
NCT00720291
Locations
🇺🇸

Medical University of South Carolina, Charleston, South Carolina, United States

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