Pembrolizumab is a highly selective IgG4-kappa humanized monoclonal antibody against PD-1 receptors. It was generated by grafting the variable sequences of a very high-affinity mouse antihuman PD-1 antibody onto a human IgG4-kappa isotype containing a stabilizing S228P Fc mutation. It contains 32 cysteine residues and the complete folded molecule includes 4 disulfide linkages as interchain bonds and 23 interchain bonds. It was developed by Merck & Co and first approved for the treatment of metastatic malignant melanoma by the FDA on September 4, 2014, becoming the first approved therapy against PD-1. In the time since its initial approval, pembrolizumab has been granted approval in the treatment of a wide variety of cancers.
Pembrolizumab is indicated for the following conditions:
For all approved adult indications, pembrolizumab may be used for an additional 6 weeks at 400mg weekly.
University of Michigan, Ann Arbor, Michigan, United States
University of Chicago, Chicago, Illinois, United States
James Cancer Hospital, Columbus, Ohio, United States
Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, United States
University of Iowa, Holden Comprehensive Cancer Center, Iowa City, Iowa, United States
Penn State Hershey Cancer Institute, Hershey, Pennsylvania, United States
Fort Wayne Oncology & Hematology, Inc., Fort Wayne, Indiana, United States
Northern Indiana Cancer Research Consortium, South Bend, Indiana, United States
Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, United States
Hillman Cancer Center, Pittsburgh, Pennsylvania, United States
Roswell Park Cancer Institute, Buffalo, New York, United States
M D Anderson Cancer Center, Houston, Texas, United States
University of California, Los Angeles, Los Angeles, California, United States
Dana-Farber Cancer Institute, Boston, Massachusetts, United States
Massachusetts General Hospital, Boston, Massachusetts, United States
Call for Information (Investigational Site 0071), Sioux Falls, South Dakota, United States
Merck Sharp & Dohme Lda., Paco D'arcos, Portugal
Call for Information (Investigational Site 0019), Aurora, Colorado, United States
University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, United States
Medical College of Wisconsin, Milwaukee, Wisconsin, United States
Cancer Treatment Center of America @ Western Regional Medical Center, Goodyear, Arizona, United States
Western Regional Medical Center, Goodyear, Arizona, United States
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.