Pembrolizumab is a highly selective IgG4-kappa humanized monoclonal antibody against PD-1 receptors. It was generated by grafting the variable sequences of a very high-affinity mouse antihuman PD-1 antibody onto a human IgG4-kappa isotype containing a stabilizing S228P Fc mutation. It contains 32 cysteine residues and the complete folded molecule includes 4 disulfide linkages as interchain bonds and 23 interchain bonds. It was developed by Merck & Co and first approved for the treatment of metastatic malignant melanoma by the FDA on September 4, 2014, becoming the first approved therapy against PD-1. In the time since its initial approval, pembrolizumab has been granted approval in the treatment of a wide variety of cancers.
Pembrolizumab is indicated for the following conditions:
For all approved adult indications, pembrolizumab may be used for an additional 6 weeks at 400mg weekly.
M D Anderson Cancer Center, Houston, Texas, United States
University of California, San Francisco Medical Center, San Francisco, California, United States
Ohio State University - Wexner Medical Center, Columbus, Ohio, United States
South Texas Accelerated Research Therapeutics, San Antonio, Texas, United States
University of Michigan Health System, Ann Arbor, Michigan, United States
University of Chicago Medical Center, Chicago, Illinois, United States
MD Anderson Cancer Center / University of Texas, Houston, Texas, United States
University of Alabama at Birmingham, Birmingham, Alabama, United States
Emory University: Winship Cancer Institute, Atlanta, Georgia, United States
The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States
Indiana University Simon Cancer Center, Indianapolis, Indiana, United States
Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, Indiana, United States
Community Regional Cancer Care, Indianapolis, Indiana, United States
IU Health Central Indiana Cancer Center, Indianapolis, Indiana, United States
University of California Davis Comprehensive Cancer Center, Sacramento, California, United States
Georgetown Lombardi Comprehensive Cancer Center, Washington, District of Columbia, United States
Massachusetts General Hospital, Boston, Massachusetts, United States
Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
Dana Farber Cancer Institute, Boston, Massachusetts, United States
Research Site, Yakima, Washington, United States
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.