Octafluoropropane
- Generic Name
- Octafluoropropane
- Brand Names
- Definity, Luminity, Optison
- Drug Type
- Small Molecule
- Chemical Formula
- C3F8
- CAS Number
- 76-19-7
- Unique Ingredient Identifier
- CK0N3WH0SR
- Background
Perflutren, a diagnostic drug that is intended to be used for contrast enhancement during the indicated echocardiographic procedures, is comprised of lipid-coated microspheres filled with octafluoropropane(OFP) gas. When exposed to ultrasound waves, the microspheres resonate and "echo" strong signals back to the ultrasound machine. The difference in density between the gas-filled bubbles and the blood around them creates an increased level of contrast visible in the resulting ultrasound image. During echocardiography, activated Perflutren enhances images of the inner edges or borders of the heart, producing an improved image that may enable physicians to better diagnose patients.
- Indication
Used as an ultrasound contrast imaging in cardiology and radiology.
Pancreas Ultrasound Imaging in type1 Diabetes
- Conditions
- Type1diabetesInsulitisPancreas Inflamed
- Interventions
- First Posted Date
- 2022-08-01
- Last Posted Date
- 2024-09-30
- Lead Sponsor
- University of Colorado, Denver
- Target Recruit Count
- 50
- Registration Number
- NCT05482321
- Locations
- 🇺🇸
University of Colorado Anschutz, Barbara Davis Center, Aurora, Colorado, United States
Prostate Cancer Diagnosis by Multiparametric Ultrasound (Wholemount)
- Conditions
- Prostate Carcinoma
- Interventions
- Procedure: Ultrasound
- First Posted Date
- 2022-04-20
- Last Posted Date
- 2025-05-20
- Lead Sponsor
- Thomas Jefferson University
- Target Recruit Count
- 70
- Registration Number
- NCT05336786
- Locations
- 🇺🇸
Sidney Kimmel Cancer Center at Thomas Jefferson University, Philadelphia, Pennsylvania, United States
🇳🇱Amsterdam University Medical Centers, Amsterdam, Netherlands
Contrast-Enhanced Ultrasound for the Prediction of Bile Duct Cancer Response to Radioembolization Treatment
- Conditions
- Intrahepatic Cholangiocarcinoma
- Interventions
- Procedure: Contrast-Enhanced Ultrasound
- First Posted Date
- 2022-04-14
- Last Posted Date
- 2024-11-22
- Lead Sponsor
- Thomas Jefferson University
- Target Recruit Count
- 20
- Registration Number
- NCT05328167
- Locations
- 🇺🇸
Sidney Kimmel Cancer Center at Thomas Jefferson University, Philadelphia, Pennsylvania, United States
Diagnosing Compartment Syndrome With SHAPE vs Elastography
- First Posted Date
- 2022-02-21
- Last Posted Date
- 2023-12-12
- Lead Sponsor
- Thomas Jefferson University
- Target Recruit Count
- 15
- Registration Number
- NCT05247541
- Locations
- 🇺🇸
Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States
Multi-organ Transit Time Acquisition Using Contrast Ultrasound
- First Posted Date
- 2021-11-26
- Last Posted Date
- 2024-07-16
- Lead Sponsor
- Vanderbilt University Medical Center
- Target Recruit Count
- 16
- Registration Number
- NCT05135169
- Locations
- 🇺🇸
VUMC, Nashville, Tennessee, United States
Contrast Enhanced Ultrasound for Renal Obstruction
- Conditions
- Renal ObstructionKidney; Obstruction
- Interventions
- First Posted Date
- 2021-10-25
- Last Posted Date
- 2025-01-08
- Lead Sponsor
- University of Michigan
- Target Recruit Count
- 10
- Registration Number
- NCT05090800
- Locations
- 🇺🇸
University of Michigan, Ann Arbor, Michigan, United States
Development of Hardware and Software for Pulmonary Magnetic Resonance Imaging Using Inhaled Tracer Gases
- Conditions
- Healthy Volunteers
- First Posted Date
- 2021-01-27
- Last Posted Date
- 2024-11-08
- Lead Sponsor
- The Hospital for Sick Children
- Target Recruit Count
- 50
- Registration Number
- NCT04726618
- Locations
- 🇨🇦
Hospital for Sick Children, Toronto, Ontario, Canada
Contrast-Enhanced Ultrasound Scan for the Estimation of Tissue Pressure in Patients With Breast Cancer
- Conditions
- Breast Carcinoma
- Interventions
- Procedure: UltrasonsgraphyProcedure: Contrast - Enhanced Ultrasound
- First Posted Date
- 2021-01-25
- Last Posted Date
- 2024-02-15
- Lead Sponsor
- Thomas Jefferson University
- Target Recruit Count
- 25
- Registration Number
- NCT04721886
- Locations
- 🇺🇸
Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States
Prediction of Neoadjuvant Chemotherapy Response Using Contrast-Enhanced Ultrasound in Patients With Locally Advanced Breast Cancer
- Conditions
- Locally Advanced Breast CarcinomaAnatomic Stage III Breast Cancer AJCC v8
- Interventions
- First Posted Date
- 2021-01-20
- Last Posted Date
- 2025-04-29
- Lead Sponsor
- Kibo Nam
- Target Recruit Count
- 200
- Registration Number
- NCT04715958
- Locations
- 🇺🇸
UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas, United States
🇺🇸Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States
🇺🇸Mayo Clinic, Rochester, Minnesota, United States
Novel MRI-Guided Ultrasound Stimulated Microbubble Radiation Treatment for Patients With Chest-wall and Breast Cancer
- First Posted Date
- 2020-06-16
- Last Posted Date
- 2023-12-13
- Lead Sponsor
- Sunnybrook Health Sciences Centre
- Target Recruit Count
- 20
- Registration Number
- NCT04431674
- Locations
- 🇨🇦
Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
Drug Development Updates
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