Octafluoropropane
- Generic Name
- Octafluoropropane
- Brand Names
- Definity, Luminity, Optison
- Drug Type
- Small Molecule
- Chemical Formula
- C3F8
- CAS Number
- 76-19-7
- Unique Ingredient Identifier
- CK0N3WH0SR
- Background
Perflutren, a diagnostic drug that is intended to be used for contrast enhancement during the indicated echocardiographic procedures, is comprised of lipid-coated microspheres filled with octafluoropropane(OFP) gas. When exposed to ultrasound waves, the microspheres resonate and "echo" strong signals back to the ultrasound machine. The difference in density between the gas-filled bubbles and the blood around them creates an increased level of contrast visible in the resulting ultrasound image. During echocardiography, activated Perflutren enhances images of the inner edges or borders of the heart, producing an improved image that may enable physicians to better diagnose patients.
- Indication
Used as an ultrasound contrast imaging in cardiology and radiology.
Microbubble-Enhanced Clotbust Treatment of Acute Ischemic Stroke
- Conditions
- Acute Ischemic Stroke
- First Posted Date
- 2007-07-27
- Last Posted Date
- 2007-07-27
- Lead Sponsor
- ImaRx Therapeutics
- Registration Number
- NCT00507806
DMP115 in Patients With an Ejection Fraction Between 25%-40% to Evaluate the Use of Contrast Echocardiography to Assess Heart Function
- Conditions
- Ventricular Ejection Fraction
- First Posted Date
- 2006-11-20
- Last Posted Date
- 2011-05-20
- Lead Sponsor
- Lantheus Medical Imaging
- Target Recruit Count
- 131
- Registration Number
- NCT00401687
- Locations
- 🇺🇸
University of Arizona, Tucson, Arizona, United States
🇺🇸University of Nebraska Medical Center, Omaha, Nebraska, United States
🇺🇸Saint Lukes Mid America Heart Institute, Kansas City, Missouri, United States
Assessing Myocardial Blood Flow and Blood Flow Reserve by Transoesophageal Echocardiography (TEE)
- Conditions
- Coronary Artery Disease
- First Posted Date
- 2006-02-03
- Last Posted Date
- 2015-03-25
- Lead Sponsor
- University Hospital, Basel, Switzerland
- Registration Number
- NCT00286559
3-D Transcranial Ultrasound Analysis Study
- Conditions
- Cerebrovascular AccidentIntracranial Hypertension
- First Posted Date
- 2005-10-17
- Last Posted Date
- 2014-04-11
- Lead Sponsor
- Duke University
- Target Recruit Count
- 28
- Registration Number
- NCT00239525
- Locations
- 🇺🇸
Duke University Medical Center, Durham, North Carolina, United States
Determination of a Safe Dose of Optison in Pediatric Patients With Solid Tumors
- First Posted Date
- 2005-09-16
- Last Posted Date
- 2011-09-20
- Lead Sponsor
- St. Jude Children's Research Hospital
- Target Recruit Count
- 14
- Registration Number
- NCT00186953
- Locations
- 🇺🇸
St. Jude Children's Research Hospital, Memphis, Tennessee, United States
A Study of Stress Echocardiography in Post-Menopausal Women at Risk for Coronary Disease
- Conditions
- Coronary Artery DiseaseHeart Disease
- Interventions
- First Posted Date
- 2005-09-13
- Last Posted Date
- 2021-03-15
- Lead Sponsor
- Lantheus Medical Imaging
- Target Recruit Count
- 400
- Registration Number
- NCT00162370
- Locations
- 🇺🇸
Local Institution, Rochester, Minnesota, United States
The Silicone Study
- Conditions
- Proliferative VitreoretinopathyRetinal Detachment
- First Posted Date
- 1999-09-24
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- National Eye Institute (NEI)
- Registration Number
- NCT00000140
Drug Development Updates
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