Octafluoropropane
- Generic Name
- Octafluoropropane
- Brand Names
- Definity, Luminity, Optison
- Drug Type
- Small Molecule
- Chemical Formula
- C3F8
- CAS Number
- 76-19-7
- Unique Ingredient Identifier
- CK0N3WH0SR
- Background
Perflutren, a diagnostic drug that is intended to be used for contrast enhancement during the indicated echocardiographic procedures, is comprised of lipid-coated microspheres filled with octafluoropropane(OFP) gas. When exposed to ultrasound waves, the microspheres resonate and "echo" strong signals back to the ultrasound machine. The difference in density between the gas-filled bubbles and the blood around them creates an increased level of contrast visible in the resulting ultrasound image. During echocardiography, activated Perflutren enhances images of the inner edges or borders of the heart, producing an improved image that may enable physicians to better diagnose patients.
- Indication
Used as an ultrasound contrast imaging in cardiology and radiology.
Ultrasound with Subharmonic Imaging and Subharmonic Aided Pressure Estimation (SHAPE) to Identify Portal Hypertension
- Conditions
- Portal Hypertension
- Interventions
- Other: Electronic Health Record ReviewProcedure: Liver BiopsyOther: Medical Device Usage and EvaluationProcedure: Ultrasound Imaging
- First Posted Date
- 2025-01-28
- Last Posted Date
- 2025-03-17
- Lead Sponsor
- Mayo Clinic
- Target Recruit Count
- 60
- Registration Number
- NCT06797193
- Locations
- 🇺🇸
Mayo Clinic in Arizona, Scottsdale, Arizona, United States
🇺🇸Mayo Clinic in Florida, Jacksonville, Florida, United States
🇺🇸Mayo Clinic in Rochester, Rochester, Minnesota, United States
Contrast-enhanced Ultrasound in the Treatment of Acute Spinal Cord Injury
- First Posted Date
- 2024-10-23
- Last Posted Date
- 2025-04-27
- Lead Sponsor
- University of Washington
- Target Recruit Count
- 50
- Registration Number
- NCT06654804
- Locations
- 🇺🇸
University of Washington Harborview Medical Center, Seattle, Washington, United States
MRI-Guided Ultrasound Stimulated Microbubbles Radiation Treatment for Patients with Chest-Wall and Locally Advanced Breast Cancer
- Conditions
- Breast Cancer
- Interventions
- Device: MR-Guided Focused Ultrasound Technology
- First Posted Date
- 2024-10-09
- Last Posted Date
- 2024-10-09
- Lead Sponsor
- Sunnybrook Health Sciences Centre
- Target Recruit Count
- 30
- Registration Number
- NCT06633601
- Locations
- 🇨🇦
Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
SHAPE for ICP Assessment
- First Posted Date
- 2024-08-26
- Last Posted Date
- 2025-04-22
- Lead Sponsor
- Thomas Jefferson University
- Target Recruit Count
- 20
- Registration Number
- NCT06571786
- Locations
- 🇺🇸
Mayo Clinic, Rochester, Minnesota, United States
🇺🇸Thomas Jefferson University, Philadelphia, Pennsylvania, United States
Novel Magnetic Resonance Imaging-Guided Ultrasound-Stimulated Microbubble Radiation Treatment for Patients With Chest-Wall and Locally Advanced Breast Cancer-Phase II
- Conditions
- Breast Cancer
- Interventions
- Device: Sonalleve Focused Ultrasound Device
- First Posted Date
- 2023-12-29
- Last Posted Date
- 2023-12-29
- Lead Sponsor
- Sunnybrook Health Sciences Centre
- Target Recruit Count
- 200
- Registration Number
- NCT06185972
- Locations
- 🇨🇦
Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
Contrast Enhanced Ultrasound Medical Imaging for Identifying Breast Masses
- Conditions
- Breast Carcinoma
- Interventions
- Procedure: Contrast-Enhanced UltrasoundDrug: Sulfur Hexafluoride Lipid Microspheres
- First Posted Date
- 2023-12-14
- Last Posted Date
- 2023-12-14
- Lead Sponsor
- University of Southern California
- Target Recruit Count
- 100
- Registration Number
- NCT06171607
- Locations
- 🇺🇸
Los Angeles County-USC Medical Center, Los Angeles, California, United States
🇺🇸USC / Norris Comprehensive Cancer Center, Los Angeles, California, United States
Multiparametric Ultrasound for the Diagnosis of Clinically Significant Prostate Cancer
- Conditions
- Prostate Carcinoma
- Interventions
- Procedure: ultiparametric Magnetic Resonance ImagingProcedure: Transrectal UltrasoundProcedure: Biopsy of Prostate
- First Posted Date
- 2023-09-06
- Last Posted Date
- 2025-04-22
- Lead Sponsor
- Thomas Jefferson University
- Target Recruit Count
- 300
- Registration Number
- NCT06024772
- Locations
- 🇳🇱
Amsterdam Medical Center, Amsterdam-Zuidoost, Netherlands
🇺🇸Sidney Kimmel Cancer Center at Thomas Jefferson University, Philadelphia, Pennsylvania, United States
A Study of Renal Microvessel Imaging for Chronic Kidney Disease
- Conditions
- Chronic Kidney DiseasesHealthy
- Interventions
- Diagnostic Test: Super-resolution ultrasound imaging
- First Posted Date
- 2023-03-10
- Last Posted Date
- 2024-10-17
- Lead Sponsor
- Mayo Clinic
- Target Recruit Count
- 186
- Registration Number
- NCT05764642
- Locations
- 🇺🇸
Mayo Clinic Minnesota, Rochester, Minnesota, United States
MRI-Guided Focused Ultrasound Radiosensitization for Patients With Malignant Melanoma and Non Melanoma Skin Cancer
- Conditions
- Melanoma
- Interventions
- Device: Sonalleve Focused Ultrasound Device
- First Posted Date
- 2022-11-17
- Last Posted Date
- 2023-12-15
- Lead Sponsor
- Sunnybrook Health Sciences Centre
- Target Recruit Count
- 20
- Registration Number
- NCT05620290
- Locations
- 🇨🇦
Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
Contrast-Enhanced Ultrasound and Shear Wave Elastography for the Treatment of Lymphedema
- First Posted Date
- 2022-11-14
- Last Posted Date
- 2024-08-21
- Lead Sponsor
- Mayo Clinic
- Target Recruit Count
- 10
- Registration Number
- NCT05613946
- Locations
- 🇺🇸
Mayo Clinic in Rochester, Rochester, Minnesota, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.