Chlordiazepoxide
- Generic Name
- Chlordiazepoxide
- Brand Names
- Chlorax, Librax
- Drug Type
- Small Molecule
- Chemical Formula
- C16H14ClN3O
- CAS Number
- 58-25-3
- Unique Ingredient Identifier
- 6RZ6XEZ3CR
- Background
An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal.
- Indication
Chlordiazepoxide is indicated for the management of anxiety disorders or for the short-term relief of symptoms of anxiety, withdrawal symptoms of acute alcoholism, and preoperative apprehension and anxiety.
In combination with amitriptyline, chlordiazepoxide is indicated for the treatment of moderate to severe depression. In combination with clidinium, chlordiazepoxide is indicated to control emotional and somatic factors in gastrointestinal disorders, and is used as adjunctive therapy in the treatment of peptic ulcer, irritable bowel syndrome and acute enterocolitis.
- Associated Conditions
- Alcohol Withdrawal Syndrome, Anxiety Disorders, Depression, Irritable Bowel Syndrome (IBS), Peptic Ulcer Disease, Preoperative Anxiety, Acute Enterocolitis
The Efficacy of Silymarin as Adjuvant Therapy on Colorectal Cancer Patients Undergoing FOLFIRI Treatment
- First Posted Date
- 2017-04-26
- Last Posted Date
- 2020-05-13
- Target Recruit Count
- 70
- Registration Number
- NCT03130634
- Locations
- 🇨🇳
Chung-Ho Memorial Hospital, Kaohsiung Medical University:, Kaohsiung, Taiwan
Silymarin in NAFLD
- Conditions
- Non-Alcoholic Fatty Liver Disease
- Interventions
- Other: Placebo Oral Capsule
- First Posted Date
- 2016-11-25
- Last Posted Date
- 2020-11-05
- Lead Sponsor
- University Hospital Rijeka
- Registration Number
- NCT02973295
- Locations
- 🇭🇷
Clinical Hospital Centre, Rijeka, Kresimirova 42, Croatia
To Evaluate the Efficacy of DDB/Garlic Oil in Patients With Elevated Transaminase Chronic Liver Disease
- First Posted Date
- 2015-01-27
- Last Posted Date
- 2015-01-27
- Lead Sponsor
- PharmaKing
- Target Recruit Count
- 262
- Registration Number
- NCT02347319
- Locations
- 🇰🇷
The catholic university of korea, Bucheon ST. Mary's Hosipital, Bucheon, Gyeonggi-do, Korea, Republic of
Evaluation of Effects of Silymarin on Cisplatin Induced Nephrotoxicity in Upper Gastrointestinal Adenocarcinoma
- Conditions
- Cisplatin Adverse ReactionUpper GI Cancer
- Interventions
- First Posted Date
- 2013-04-11
- Last Posted Date
- 2015-05-13
- Lead Sponsor
- Tehran University of Medical Sciences
- Target Recruit Count
- 30
- Registration Number
- NCT01829178
- Locations
- 🇮🇷
Tehran University of Medical Science, Tehran, Iran, Islamic Republic of
The Efficacy of Silymarin on the Prevention of Hepatotoxicity From Antituberculosis Drugs
- First Posted Date
- 2013-02-27
- Last Posted Date
- 2013-12-24
- Lead Sponsor
- Ramathibodi Hospital
- Target Recruit Count
- 80
- Registration Number
- NCT01800487
- Locations
- 🇹🇭
Gastroenterology and Hepatology, Ramathibodi hospital, Bangkok, Thailand
Gabapentin vs Chlordiazepoxide for Ambulatory Alcohol Withdrawal
- First Posted Date
- 2012-04-06
- Last Posted Date
- 2020-08-17
- Lead Sponsor
- VA Salt Lake City Health Care System
- Target Recruit Count
- 26
- Registration Number
- NCT01573052
- Locations
- 🇺🇸
George E Wahlen VA Medical Center, Salt Lake City, Utah, United States
Effect of Prophylactic Use of Silymarin on Hepatotoxicity Induced by Anti-tuberculosis Drugs
- First Posted Date
- 2011-09-20
- Last Posted Date
- 2012-12-17
- Lead Sponsor
- Seoul National University Hospital
- Target Recruit Count
- 600
- Registration Number
- NCT01436929
- Locations
- 🇰🇷
Deog Kyeom Kim, Seoul, Korea, Republic of
Effects of Silybum Marianum on Treatment of Patients With Chronic Hepatitis C
- First Posted Date
- 2011-02-09
- Last Posted Date
- 2011-02-09
- Lead Sponsor
- Isfahan University of Medical Sciences
- Target Recruit Count
- 55
- Registration Number
- NCT01292161
- Locations
- 🇮🇷
Al-zahra university hospital, Isfahan, Iran, Islamic Republic of
Clinical Study With Silymarin in the Patients With Chronic Hepatitis C Infection Who Failed Conventional Antiviral Therapy
- First Posted Date
- 2010-12-13
- Last Posted Date
- 2013-11-25
- Lead Sponsor
- Bukwang Pharmaceutical
- Target Recruit Count
- 53
- Registration Number
- NCT01258686
- Locations
- 🇰🇷
Byung Chul, Yoo, Seoul, Korea, Republic of
Pioglitazone as an Adjunct for Moderate to Severe Depressive Disorder
- Conditions
- Major Depressive Disorder
- Interventions
- Drug: Pioglitazone+Citalopram+Chlordiazepoxide
- First Posted Date
- 2010-04-22
- Last Posted Date
- 2012-05-09
- Lead Sponsor
- Tehran University of Medical Sciences
- Target Recruit Count
- 50
- Registration Number
- NCT01109030
- Locations
- 🇮🇷
Department of psychiatry, Roozbeh psychiatric hospital, Tehran University of medical sciences, Tehran, Iran, Islamic Republic of
Drug Development Updates
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