Zileuton
- Generic Name
- Zileuton
- Brand Names
- Zyflo
- Drug Type
- Small Molecule
- Chemical Formula
- C11H12N2O2S
- CAS Number
- 111406-87-2
- Unique Ingredient Identifier
- V1L22WVE2S
- Background
Leukotrienes are substances that induce numerous biological effects including augmentation of neutrophil and eosinophil migration, neutrophil and monocyte aggregation, leukocyte adhesion, increased capillary permeability, and smooth muscle contraction. These effects contribute to inflammation, edema, mucus secretion, and bronchoconstriction in the airways of...
- Indication
For the prophylaxis and chronic treatment of asthma in adults and children 12 years of age and older.
- Associated Conditions
- Asthma, Chronic Asthma
- Associated Therapies
- -
Zileuton for the Treatment of Idiopathic Pulmonary Fibrosis
- Conditions
- Interventions
- First Posted Date
- 2005-12-06
- Last Posted Date
- 2015-12-03
- Lead Sponsor
- University of Michigan
- Target Recruit Count
- 44
- Registration Number
- NCT00262405
- Locations
- 🇺🇸
University of Michigan, Ann Arbor, Michigan, United States
Study of Oral Zileuton in the Treatment of Moderate to Severe Facial Acne Vulgaris
- Conditions
- First Posted Date
- 2004-12-08
- Last Posted Date
- 2007-02-07
- Lead Sponsor
- Critical Therapeutics
- Target Recruit Count
- 90
- Registration Number
- NCT00098358
- Locations
- 🇺🇸
Rivergate Dermatology, Goodlettsville, Tennessee, United States
🇺🇸SUNY Downstate Medical Center, Brooklyn, New York, United States
🇺🇸Dermatology Associates of Rochester, Rochester, New York, United States
Carboplatin and Gemcitabine Combined With Celecoxib and/or Zileuton in Treating Patients With Advanced Non-Small Cell Lung Cancer
- Conditions
- Interventions
- First Posted Date
- 2003-10-07
- Last Posted Date
- 2016-06-30
- Lead Sponsor
- Alliance for Clinical Trials in Oncology
- Target Recruit Count
- 140
- Registration Number
- NCT00070486
- Locations
- 🇺🇸
Veterans Affairs Medical Center - Columbia (Truman Memorial), Columbia, Missouri, United States
🇺🇸Ellis Fischel Cancer Center at University of Missouri - Columbia, Columbia, Missouri, United States
🇺🇸CCOP - North Shore University Hospital, Manhasset, New York, United States
Zileuton in Preventing Lung Cancer in Patients With Bronchial Dysplasia
- Conditions
- First Posted Date
- 2003-03-07
- Last Posted Date
- 2013-04-29
- Lead Sponsor
- Barbara Ann Karmanos Cancer Institute
- Target Recruit Count
- 38
- Registration Number
- NCT00056004
- Locations
- 🇺🇸
Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, United States
Drug Development Updates
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