Curcumin

Generic Name: Curcumin

Brand Names: -

Drug Type: Small Molecule

Chemical Formula: C_₂₁H_₂₀O_₆

CAS Number: 458-37-7

Unique Ingredient Identifier: IT942ZTH98

Background: Curcumin, also known as diferuloylmethane, is an active component in the golden spice turmeric (Curcuma longa) and in Curcuma xanthorrhiza oil. It is a highly pleiotropic molecule that exhibits antibacterial, anti-inflammatory, hypoglycemic, antioxidant, wound-healing, and antimicrobial activities . Due to these properties, curcumin has been investigated for...

Indication: No approved therapeutic indications.

Associated Conditions: -

Associated Therapies: -

Clinical Trials

Safety of Anal Curcumin

Phase 1

Not yet recruiting

Conditions: Anal High Grade Squamous Intraepithelial Lesion

Interventions: Drug: Curcumin

First Posted Date: 2024-10-03

Last Posted Date: 2024-12-05

Lead Sponsor: Lisa Flowers

Target Recruit Count: 48

Registration Number: NCT06626230

Locations: 🇺🇸
Grady Memorial Hospital, Atlanta, Georgia, United States
🇺🇸
Grady Hospital - Ponce De Leon Clinic, Atlanta, Georgia, United States

RQC for the Prevention of Alzheimer's Disease and Retinal Amyloid-β

Phase 2

Not yet recruiting

Conditions: Cognitive Decline
Alzheimer Disease
Mild Cognitive Impairment

Interventions: Drug: Resveratrol, Quercetin, and Curcumin (RQC)
Drug: Curcumin

First Posted Date: 2024-06-24

Last Posted Date: 2024-06-26

Lead Sponsor: Zaparackas and Knepper LTD

Target Recruit Count: 200

Registration Number: NCT06470061

Locations: 🇺🇸
Zaparackas & Knepper Ltd., Chicago, Illinois, United States

Oral Curcumin for the Treatment of Pain of Thumb Base Joint (CMC) Arthritis

Phase 1

Conditions: Arthritis of Carpometacarpal Joint of Left Thumb
Arthritis of Carpometacarpal Joint of Right Thumb

Interventions: Drug: Curcumin
Drug: Placebo

First Posted Date: 2024-04-11

Last Posted Date: 2024-12-13

Lead Sponsor: Brent DeGeorge

Target Recruit Count: 100

Registration Number: NCT06359665

Locations: 🇺🇸
University of Virginia, Charlottesville, Virginia, United States

Curcumin VS Photo-bio-modulation Therapy of Oral Mucositis in Pediatric Patients Undergoing Anti-Cancer Non-invasive Treatment

Phase 1

Completed

Conditions: Oral Mucositis
Pediatric Cancer

Interventions: Drug: Curcumin
Device: Laser

First Posted Date: 2023-09-21

Last Posted Date: 2024-08-05

Lead Sponsor: Riyadh Elm University

Target Recruit Count: 90

Registration Number: NCT06044142

Locations: 🇸🇦
Riyadh Elm University, Riyadh, Ar Riyadh, Saudi Arabia

Concomitant Curcumin Palliative Radiotherapy in Advanced Cervical Cancer Trial

Not Applicable

Not yet recruiting

Conditions: Cervical Cancer

Interventions: Drug: Curcumin
Radiation: Palliative radiotherapy

First Posted Date: 2023-07-17

Last Posted Date: 2024-12-03

Lead Sponsor: Addis Ababa University

Target Recruit Count: 27

Registration Number: NCT05947513

Clinical Study of Curcumin in Preventing Postoperative Adhesion of Bilateral Vocal Cords

Phase 1

Recruiting

Conditions: Laryngeal Leucoplakia
Glottic Web of Larynx
Laryngeal Stenosis
Laryngeal Papilloma
Glottic Carcinoma
Laryngeal Polyp

Interventions: Drug: Curcumin
Drug: Mitomycin-C

First Posted Date: 2023-01-18

Last Posted Date: 2023-05-06

Lead Sponsor: Eye & ENT Hospital of Fudan University

Target Recruit Count: 100

Registration Number: NCT05688488

Locations: 🇨🇳
Eye & ENT Hospital of Fudan University, Shanghai, Shanghai, China

The Effect of Curcumin Against Colistin-induced Nephrotoxicity

Phase 3

Recruiting

Conditions: Acute Kidney Injury
Drug-Induced Nephropathy

Interventions: Drug: Colistin
Drug: Curcumin

First Posted Date: 2022-11-14

Last Posted Date: 2023-10-31

Lead Sponsor: October 6 University

Target Recruit Count: 214

Registration Number: NCT05613361

Locations: 🇪🇬
Cairo University Hospitals, Cairo, Egypt

A Study to Evaluate the Safety and Efficacy of RQC for AMD

Phase 2

Conditions: Age-related Macular Degeneration

Interventions: Drug: Resveratrol, Quercetin, Curcumin (RQC)
Drug: Curcumin

First Posted Date: 2021-09-30

Last Posted Date: 2021-09-30

Lead Sponsor: Paul A Knepper, MD PhD

Target Recruit Count: 150

Registration Number: NCT05062486

Locations: 🇺🇸
Zaparackas M.D. & Knepper M.D. Ph.D., Ltd, Chicago, Illinois, United States

Safety and Efficacy of Curcumin in Children With Acute Lymphoblastic Leukemia

Phase 2

Completed

Conditions: Acute Lymphoblastic Leukemia, Pediatric

Interventions: Dietary Supplement: Standard of Care
Drug: Curcumin

First Posted Date: 2021-09-16

Last Posted Date: 2024-01-08

Lead Sponsor: Ain Shams University

Target Recruit Count: 30

Registration Number: NCT05045443

Locations: 🇪🇬
Pediatric Hematology Oncology and BMT Unit, Faculty of Medicine Ain Shams University, Cairo, Non-US, Egypt

Alveolar Ridge Augmentation With Curcumin Combined With Xenograft

Phase 4

Not yet recruiting

Conditions: Horizontal Alveolar Bone Loss

Interventions: Drug: Curcumin

First Posted Date: 2021-07-21

Last Posted Date: 2021-07-21

Lead Sponsor: Ain Shams University

Target Recruit Count: 18

Registration Number: NCT04971382

Locations: 🇪🇬
faculty of dentistry Ain shams university, Cairo, Egypt

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