MedPath

Calcium

Generic Name
Calcium
Drug Type
Small Molecule
Chemical Formula
Ca
CAS Number
7440-70-2
Unique Ingredient Identifier
SY7Q814VUP
Background

Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. The skeleton acts as a major mineral storage site for the element and releases Ca2+ ions into the bloodstream under controlled conditions. Circulating calcium is either in the free, ionized form or bound to blood proteins such as serum albumin. Although calcium flow to and from the bone is neutral, about 5 mmol is turned over a day. Bone serves as an important storage point for calcium, as it contains 99% of the total body calcium. Low calcium intake may also be a risk factor in the development of osteoporosis. The best-absorbed form of calcium from a pill is a calcium salt like carbonate or phosphate. Calcium gluconate and calcium lactate are absorbed well by pregnant women. Seniors absorb calcium lactate, gluconate and citrate better unless they take their calcium supplement with a full breakfast.

Indication

Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. It is vital in cell signaling, muscular contractions, bone health, and signalling cascades.

Associated Conditions
Calcium Deficiency, Deficiency, Vitamin D, Osteodystrophy, Osteomalacia, Osteoporosis, Chronic Hypocalcemia, Chronic Hypocalcemia caused by anticonvulsant medications
Associated Therapies
Care of the Joint, Mineral supplementation therapy, Nutritional supplementation

Clinical Efficacy of Novel Jasminum-based Calcium Hydroxide Medicament

Not Applicable
Completed
Conditions
Necrotic Pulp
Acute Apical Periodontitis of Pulpal Origin
Interventions
Drug: Nano-reinforced calcium hydroxide medicament
First Posted Date
2024-10-22
Last Posted Date
2024-10-30
Lead Sponsor
Pakistan Institute of Medical Sciences
Target Recruit Count
60
Registration Number
NCT06653608
Locations
🇵🇰

School of Dentistry, Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad, Pakistan

Pharmacokinetics of Oral Calcium Carbonate in Parturients

Early Phase 1
Not yet recruiting
Conditions
Pregnancy
Pharmacokinetics
Postpartum Hemorrhage
Interventions
First Posted Date
2024-10-21
Last Posted Date
2024-11-20
Lead Sponsor
Stanford University
Target Recruit Count
60
Registration Number
NCT06650930
Locations
🇺🇸

Stanford Children's Health, Lucile Packard Children's Hospital, Stanford, California, United States

Adebrelimab Combined with Irinotecan Liposomes, 5-FU, CF ± Lenvatinib As First-line Treatment for Advanced ICC

Phase 2
Not yet recruiting
Conditions
Intrahepatic Cholangiocarcinoma (Icc)
Interventions
First Posted Date
2024-10-18
Last Posted Date
2024-10-18
Lead Sponsor
Harbin Medical University
Target Recruit Count
68
Registration Number
NCT06648525
Locations
🇨🇳

Harbin Medical University, Harbin, Heilongjiang, China

Calcium Carbonate to Augment Labor Contractions

Phase 4
Recruiting
Conditions
Labor Dystocia
Labor Induction
Labor Augmentation
Interventions
Drug: Standard Dose Synthetic Pitocin
First Posted Date
2024-08-30
Last Posted Date
2024-11-22
Lead Sponsor
Weill Medical College of Cornell University
Target Recruit Count
50
Registration Number
NCT06580782
Locations
🇺🇸

Weill Cornell Medicine, New York, New York, United States

Effectiveness of Asiaticoside as Intracanal Medication on Infectious/Inflammatory Contents in Teeth With Apical Periodontitis

Phase 2
Recruiting
Conditions
Intracanal Medication
Interventions
First Posted Date
2024-08-22
Last Posted Date
2024-08-22
Lead Sponsor
Mansoura University
Target Recruit Count
36
Registration Number
NCT06566508
Locations
🇪🇬

Mansoura university, Mansoura, Egypt

Study of ONO-4578 and XELOX/FOLFOX Plus Bevacizumab in Colorectal Cancer

First Posted Date
2024-08-09
Last Posted Date
2024-08-09
Lead Sponsor
Ono Pharmaceutical Co. Ltd
Target Recruit Count
40
Registration Number
NCT06547385
Locations
🇯🇵

Cancer Institute Hospital of JFCR, Koto-Ku, Tokyo, Japan

🇯🇵

Osaka Medical and Pharmaceutical University Hospital, Takatsuki-shi, Osaka, Japan

🇯🇵

National Cancer Center Hospital East, Kashiwa-shi, Chiba, Japan

and more 6 locations

Evaluating the Safety and Efficacy of AMOR-1 As a Treatment for Hypocalcemia Associated with Hypoparathyroidism in Adults

Phase 2
Recruiting
Conditions
Hypoparathyroidism
Interventions
First Posted Date
2024-08-09
Last Posted Date
2025-01-29
Lead Sponsor
Amorphical Ltd.
Target Recruit Count
81
Registration Number
NCT06547151
Locations
🇮🇱

Soroka Medical Center, Beer Sheva, Israel

🇮🇱

Hadassah Ein Kerem Medical Center, Jerusalem, Israel

🇮🇱

Barzilai Medical Center, Ashkelon, Israel

and more 3 locations

Adebelimab Combined With Irinotecan Liposomal Injection, Oxaliplatin, Fluorouracil and Calcium Folinate Are Used in the First-line Treatment of Pancreatic Cancer Liver Metastasis Efficacy and Safety

Phase 2
Recruiting
Conditions
Pancreatic Cancer Metastatic to Liver
Interventions
First Posted Date
2024-07-31
Last Posted Date
2024-07-31
Lead Sponsor
Jiang Long
Target Recruit Count
40
Registration Number
NCT06531278
Locations
🇨🇳

Shanghai General Hospital, Shanghai, Shanghai, China

A Study of Enhancing Drug Prophylaxis of Venous Thromboembolism in Chinese Colorectal Cancer Surgery

Not yet recruiting
Conditions
Colorectal Cancer
Interventions
First Posted Date
2024-07-22
Last Posted Date
2024-07-22
Lead Sponsor
RenJi Hospital
Target Recruit Count
914
Registration Number
NCT06513481

A Phase 2 Study of SSGJ-707 in Metastatic Colorectal Cancer Patients

Phase 2
Not yet recruiting
Conditions
Metastatic Colorectal Cancer
Interventions
First Posted Date
2024-07-10
Last Posted Date
2024-08-09
Lead Sponsor
Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd.
Target Recruit Count
130
Registration Number
NCT06493760
Locations
🇨🇳

Liu Tianshu, Shanghai, Shanghai, China

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