Pentamidine
- Generic Name
- Pentamidine
- Brand Names
- Nebupent, Pentam
- Drug Type
- Small Molecule
- Chemical Formula
- C19H24N4O2
- CAS Number
- 100-33-4
- Unique Ingredient Identifier
- 673LC5J4LQ
- Background
Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.
- Indication
For the treatment of pneumonia due to Pneumocystis carinii.
- Associated Conditions
- Pneumocystis Jirovecii Pneumonia, Trypanosomiasis
- Associated Therapies
- -
Combination Immunosuppressive Therapy to Prevent Kidney Transplant Rejection in Adults
- Conditions
- Interventions
- First Posted Date
- 2004-03-02
- Last Posted Date
- 2018-06-29
- Lead Sponsor
- University of Wisconsin, Madison
- Target Recruit Count
- 10
- Registration Number
- NCT00078559
- Locations
- ๐บ๐ธ
University of Wisconsin - Department of Medicine, Madison, Wisconsin, United States
A Study of Pentamidine in the Prevention of Pneumocystis Carinii Pneumonia (PCP) in HIV-Infected Children Who Cannot Take Trimethoprim-Sulfamethoxazole
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-01
- Target Recruit Count
- 32
- Registration Number
- NCT00001027
- Locations
- ๐บ๐ธ
Usc La Nichd Crs, Los Angeles, California, United States
๐บ๐ธChicago Children's CRS, Chicago, Illinois, United States
๐บ๐ธUCLA-Los Angeles/Brazil AIDS Consortium (LABAC) CRS, Los Angeles, California, United States
Aerosols in the Treatment of Pneumocystis Pneumonia: A Pilot Study Quantitating the Deposition of Aerosolized Pentamidine as Delivered in ACTG 040 and Comparing Its Toxicity With Parenteral Pentamidine Therapy
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-03
- Target Recruit Count
- 45
- Registration Number
- NCT00000722
- Locations
- ๐บ๐ธ
SUNY - Stony Brook, Stony Brook, New York, United States
A Comparison of Atovaquone and Pentamidine in the Prevention of Pneumocystis Carinii Pneumonia in HIV-Infected Patients Who Cannot Take TMP/SMX
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- Glaxo Wellcome
- Target Recruit Count
- 615
- Registration Number
- NCT00002340
- Locations
- ๐บ๐ธ
Holmes Hosp, Cincinnati, Ohio, United States
๐บ๐ธHampton Roads Med Specialists, Hampton, Virginia, United States
๐บ๐ธBay Area AIDS Consortium, Tampa, Florida, United States
A Controlled Comparative Trial of Sulfamethoxazole-Trimethoprim Versus Aerosolized Pentamidine for Secondary Prophylaxis of Pneumocystis Carinii Pneumonia in AIDS Patients Receiving Azidothymidine (AZT)
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-03
- Target Recruit Count
- 322
- Registration Number
- NCT00000727
- Locations
- ๐บ๐ธ
University of Washington AIDS CRS, Seattle, Washington, United States
๐บ๐ธBmc Actg Crs, Boston, Massachusetts, United States
๐บ๐ธIndiana Univ. School of Medicine, Infectious Disease Research Clinic, Indianapolis, Indiana, United States
A Controlled Trial Comparing the Efficacy of Aerosolized Pentamidine and Parenteral / Oral Trimethoprim - Sulfamethoxazole in the Treatment of Pneumocystis Carinii Pneumonia in AIDS
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- LyphoMed
- Registration Number
- NCT00002056
- Locations
- ๐บ๐ธ
LyphoMed Inc, Rosemont, Illinois, United States
A Phase II Open Randomized Comparison of 566C80 and Pentamidine Isethionate for the Treatment of Pneumocystis Carinii Pneumonia in AIDS Patients Who Are Intolerant of Trimethoprim / Sulfamethoxazole
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- Glaxo Wellcome
- Registration Number
- NCT00001996
- Locations
- ๐บ๐ธ
UCI Med Ctr, Orange, California, United States
๐บ๐ธCedars Sinai Med Ctr, Los Angeles, California, United States
๐บ๐ธAIDS Community Research Consortium, Redwood City, California, United States
A Double-Blind Group Comparative Study To Evaluate the Long-Term Safety and Effectiveness of Two Different Doses of Aerosol Pentamidine in the Prophylaxis of Pneumocystis Carinii Pneumonia in AIDS Patients With Multiple Episodes of PCP
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- Fisons
- Registration Number
- NCT00002055
- Locations
- ๐บ๐ธ
Northwestern Univ Med School, Chicago, Illinois, United States
๐บ๐ธBeth Israel Deaconess - West Campus, Boston, Massachusetts, United States
๐บ๐ธGeorgetown Univ, Washington, District of Columbia, United States
A Double-Blind Placebo-Controlled Group Comparative Study To Evaluate the Safety and Effectiveness of Aerosol Pentamidine in the Prophylaxis of Pneumocystis Carinii Pneumonia in Patients With AIDS Post First Episode PCP
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- Fisons
- Registration Number
- NCT00002053
- Locations
- ๐บ๐ธ
Fisons Corp, Rochester, New York, United States
A Double-Blind Study To Evaluate the Long-Term Safety and Effectiveness of 60 mg Versus 120 mg of Aerosol Pentamidine in the Prophylaxis of Pneumocystis Carinii Pneumonia in AIDS Patients
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- Fisons
- Registration Number
- NCT00002054
- Locations
- ๐บ๐ธ
Fisons Corp, Rochester, New York, United States
Drug Development Updates
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