Pregabalin
- Generic Name
- Pregabalin
- Brand Names
- Lyrica, Pregabalin Accord, Pregabalin Pfizer, Pregabalin Sandoz, Pregabalin Mylan, Pregabalin Zentiva
- Drug Type
- Small Molecule
- Chemical Formula
- C8H17NO2
- CAS Number
- 148553-50-8
- Unique Ingredient Identifier
- 55JG375S6M
- Background
Pregabalin is structurally similar to gamma-aminobutyric acid (GABA) - an inhibitory neurotransmitter. It may be used to manage neuropathic pain, postherpetic neuralgia, and fibromyalgia among other conditions. Although as per the FDA Label the mechanism of action has not been definitively defined, there is evidence that pregabalin exerts its effects by binding to the α2δ subunit of voltage-dependent calcium channels. Pregabalin is marketed by Pfizer under the trade name Lyrica and Lyrica Cr (extended release). It may have dependence liability if misused but the risk appears to be highest in patients with current or past substance use disorders.
- Indication
Pregabalin is indicated for the management of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, fibromyalgia, neuropathic pain associated with spinal cord injury, and as adjunctive therapy for the treatment of partial-onset seizures in patients 1 month of age and older.
- Associated Conditions
- Diabetic Peripheral Neuropathic Pain (DPN), Epilepsies, Fibromyalgia, Generalized Anxiety Disorder, Neuropathic Pain, Partial-Onset Seizures, Peripheral Neuropathic Pain, Peripheral neuropathy, Postherpetic Neuralgia
- Associated Therapies
- -
Cebranopadol Efficacy and Safety in Diabetic Patients Suffering From Chronic Pain Caused by Damage to the Nerves
- First Posted Date
- 2013-09-11
- Last Posted Date
- 2021-07-15
- Lead Sponsor
- Tris Pharma, Inc.
- Target Recruit Count
- 699
- Registration Number
- NCT01939366
- Locations
- 🇦🇹
AT001, Vienna, Austria
🇦🇹AT004, Senftenberg, Austria
🇦🇹AT003, Vienna, Austria
Preoperative Pain Control in Liver Surgery Patients
- Conditions
- Interventions
- First Posted Date
- 2013-08-16
- Last Posted Date
- 2016-03-31
- Lead Sponsor
- Eastern Hepatobiliary Surgery Hospital
- Target Recruit Count
- 40
- Registration Number
- NCT01923948
- Locations
- 🇨🇳
Eastern Hepatobiliary Surgery Hospital, Shanghai, China
Functional Neuroimaging in Fibromyalgia Patients Receiving tDCS
- First Posted Date
- 2013-07-22
- Last Posted Date
- 2013-07-22
- Lead Sponsor
- Hospital de Clinicas de Porto Alegre
- Target Recruit Count
- 34
- Registration Number
- NCT01904097
- Locations
- 🇧🇷
Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil
A Study to Evaluate Efficacy of 『Opast Tablet』for Neurologic Claudication in Patients With Lumbar Spinal Stenosis
- Conditions
- Interventions
- First Posted Date
- 2013-06-27
- Last Posted Date
- 2015-12-22
- Lead Sponsor
- Yungjin Pharm. Co., Ltd.
- Target Recruit Count
- 182
- Registration Number
- NCT01888536
- Locations
- 🇰🇷
Hallym University Sacred Heart Hospital, Anyang-si, Gyeonggi-do, Korea, Republic of
🇰🇷Inje University Sanggye Paik Hospital, Seoul, Korea, Republic of
🇰🇷KyungHee University Medical Center, Seoul, Korea, Republic of
Effect of Pregabalin in Patients With Radiotherapy-related Neuropathic Pain
- First Posted Date
- 2013-06-05
- Last Posted Date
- 2018-05-25
- Target Recruit Count
- 137
- Registration Number
- NCT01869569
- Locations
- 🇨🇳
Cancer Center of Sun Yat-sen University, Guangzhou, Guangdong, China
🇨🇳Guangzhou Huiai Hospital, Guangzhou, Guangdong, China
🇨🇳Zengcheng People's Hospital, Guangzhou, Guangdong, China
Research Examining Gulf War Illness in Our Nations Service Members
- Conditions
- Interventions
- First Posted Date
- 2013-05-03
- Last Posted Date
- 2021-03-12
- Lead Sponsor
- VA Office of Research and Development
- Target Recruit Count
- 112
- Registration Number
- NCT01846182
- Locations
- 🇺🇸
Central Texas Veterans Health Care System Waco VA Medical Center, Waco, TX, Waco, Texas, United States
🇺🇸Central Texas Veterans Health Care System, Temple, TX, Temple, Texas, United States
Increased Sensitivity to Pain Caused by Opioids in People Who Have Abused Prescription Opioids
- First Posted Date
- 2013-04-01
- Last Posted Date
- 2017-02-09
- Lead Sponsor
- Georgetown University
- Target Recruit Count
- 4
- Registration Number
- NCT01821430
- Locations
- 🇺🇸
Georgetown University, Washington, District of Columbia, United States
Preoperative Pain Control in Gastric Bypass Surgery Patients
- Conditions
- Interventions
- First Posted Date
- 2013-02-28
- Last Posted Date
- 2022-07-14
- Lead Sponsor
- Legacy Health System
- Target Recruit Count
- 61
- Registration Number
- NCT01801189
- Locations
- 🇺🇸
Legacy Good Samaritan Medical Center, Portland, Oregon, United States
Special Investigation of Pregabalin for Fibromyalgia (Regulatory Post Marketing Commitment Plan)
- First Posted Date
- 2013-01-23
- Last Posted Date
- 2023-10-10
- Target Recruit Count
- 534
- Registration Number
- NCT01773993
Evaluation of the Impact of Training on Outcome Measures in Subjects With Painful Diabetic Neuropathy
- First Posted Date
- 2013-01-18
- Last Posted Date
- 2013-01-18
- Lead Sponsor
- Analgesic Solutions
- Target Recruit Count
- 90
- Registration Number
- NCT01770964
- Locations
- 🇺🇸
Blair Medical Associates, Inc., Altoona, Pennsylvania, United States
🇺🇸St. Elizabeth's Medica Center, Brighton, Massachusetts, United States
🇺🇸MedVadis Research Corporation, Watertown, Massachusetts, United States
Drug Development Updates
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